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The map label for this gene is lip2 [H]

Identifier: 17548029

GI number: 17548029

Start: 3573762

End: 3574730

Strand: Reverse

Name: lip2 [H]

Synonym: RSc3312

Alternate gene names: 17548029

Gene position: 3574730-3573762 (Counterclockwise)

Preceding gene: 17548030

Following gene: 17548025

Centisome position: 96.19

GC content: 71.72

Gene sequence:

>969_bases
ATGGCCGTCGATCCCCAGATCCTGCAGTTCCACCAACGCCTTGCCGAACGGTTCGGCGCCTTGCCGCTGCCGGCCGACGC
GCTGGCCCGGCGCGCACGCTTCGCAGCCGTCGCCGAGGTCTTGGCGCGGCCGGATCCCGAGGGGATCGAGGCGTCGGACC
TGACCCTGCCGCTGCCGGGCCGCACGCTCGATGCGGTGATGTTCCGGCCGCGCAGCGTGCAGCGTCCGCGCCTGCTGGTG
TGGTTCCATGGCGAAGGCTGGATGGTGGGGGCCGCGCGCACCACGCACCGCCTGATGTGCGCGCTGCTGGCGGCCGACAC
CGGCTGCGCGGTGATCAGCGTCGACTATCGCCTCGCGCCTGAGCATCCGTTTCCGGCGCCCACCGACGATGCGCGCGATG
CGCTGGCTTACCTGGCGGAGCAGCGGTTGCATCTGTCGCTCGATCCGGATTTCCTGGCCGTGGGCGGGGACAGCGCGGGC
GGGCATCTGGCGGCGCAGGCCGCGCAAGCGGTGCACGACAGGGTGCGGCAGGGCCTCGTGACGGCGCAGCTGCTGGTCTG
TCCCGCTACCATGCCGGCCTTCGGCAGCGAGAGCTACAGCGCCTTTGCGCAGGGCCCGGGCCTGACGCGCGACGAAATGC
GCTGGTACTGGGCGCAGTTCATCGGCGAGGCGGCGCTCGATCGGCCGCTGGCCGAGCAGGATGCGCGCCTCTTCCTGATG
GCCGATCCGCCCGCTCACCTGCCGCCCGACACGGTGGTGATCGTGGCCGCGCACGACGTGCTGCGCGACGATGGTCTGGC
CTACGCCGACCACCTTGTGCAGCACGGTGCCCAAGTCGTCACCATCGAGGCTTCGGGCATGACCCACGGCTTTGCGCGCC
TGCAGCCCGAAGCGGAGCGGGCACGCGAATGGATGCGCCGCGCGGCGCACGCTTTCGTGGGAATGATCGGGGGGGATGCC
GCCGGCTGA

Upstream 100 bases:

>100_bases
CCAAGATCGAGCACTGGCGCCTCGGTCTCGGCGAGCGGGGCTGAGCGCGCGCGGCGTCCCGCGCTACACTTCGGCGCTCT
GCGCAACGTCTATCCCCGCC

Downstream 100 bases:

>100_bases
CGCGTCAGTGCGGAGGGCGTACCCGGAACCTCGCCAGCACGCGGCGTGTGACGAACAGCGAGAGGTAATCGTGTACGCGG
GCCTCGGAGGCGAGCGTGCG

Product: lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MAVDPQILQFHQRLAERFGALPLPADALARRARFAAVAEVLARPDPEGIEASDLTLPLPGRTLDAVMFRPRSVQRPRLLV
WFHGEGWMVGAARTTHRLMCALLAADTGCAVISVDYRLAPEHPFPAPTDDARDALAYLAEQRLHLSLDPDFLAVGGDSAG
GHLAAQAAQAVHDRVRQGLVTAQLLVCPATMPAFGSESYSAFAQGPGLTRDEMRWYWAQFIGEAALDRPLAEQDARLFLM
ADPPAHLPPDTVVIVAAHDVLRDDGLAYADHLVQHGAQVVTIEASGMTHGFARLQPEAERAREWMRRAAHAFVGMIGGDA
AG

Sequences:

>Translated_322_residues
MAVDPQILQFHQRLAERFGALPLPADALARRARFAAVAEVLARPDPEGIEASDLTLPLPGRTLDAVMFRPRSVQRPRLLV
WFHGEGWMVGAARTTHRLMCALLAADTGCAVISVDYRLAPEHPFPAPTDDARDALAYLAEQRLHLSLDPDFLAVGGDSAG
GHLAAQAAQAVHDRVRQGLVTAQLLVCPATMPAFGSESYSAFAQGPGLTRDEMRWYWAQFIGEAALDRPLAEQDARLFLM
ADPPAHLPPDTVVIVAAHDVLRDDGLAYADHLVQHGAQVVTIEASGMTHGFARLQPEAERAREWMRRAAHAFVGMIGGDA
AG
>Mature_321_residues
AVDPQILQFHQRLAERFGALPLPADALARRARFAAVAEVLARPDPEGIEASDLTLPLPGRTLDAVMFRPRSVQRPRLLVW
FHGEGWMVGAARTTHRLMCALLAADTGCAVISVDYRLAPEHPFPAPTDDARDALAYLAEQRLHLSLDPDFLAVGGDSAGG
HLAAQAAQAVHDRVRQGLVTAQLLVCPATMPAFGSESYSAFAQGPGLTRDEMRWYWAQFIGEAALDRPLAEQDARLFLMA
DPPAHLPPDTVVIVAAHDVLRDDGLAYADHLVQHGAQVVTIEASGMTHGFARLQPEAERAREWMRRAAHAFVGMIGGDAA
G

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68051721, Length=262, Percent_Identity=25.9541984732824, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI68299767, Length=271, Percent_Identity=26.5682656826568, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI226423947, Length=250, Percent_Identity=25.2, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI157041239, Length=108, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786682, Length=246, Percent_Identity=27.2357723577236, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567059, Length=295, Percent_Identity=29.1525423728814, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 34846; Mature: 34715

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVDPQILQFHQRLAERFGALPLPADALARRARFAAVAEVLARPDPEGIEASDLTLPLPG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCC
RTLDAVMFRPRSVQRPRLLVWFHGEGWMVGAARTTHRLMCALLAADTGCAVISVDYRLAP
CCHHHHHCCCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCCEEEEEEEEECC
EHPFPAPTDDARDALAYLAEQRLHLSLDPDFLAVGGDSAGGHLAAQAAQAVHDRVRQGLV
CCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
TAQLLVCPATMPAFGSESYSAFAQGPGLTRDEMRWYWAQFIGEAALDRPLAEQDARLFLM
HHHHHEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
ADPPAHLPPDTVVIVAAHDVLRDDGLAYADHLVQHGAQVVTIEASGMTHGFARLQPEAER
ECCCCCCCCCCEEEEEEHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCHHHH
AREWMRRAAHAFVGMIGGDAAG
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVDPQILQFHQRLAERFGALPLPADALARRARFAAVAEVLARPDPEGIEASDLTLPLPG
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCC
RTLDAVMFRPRSVQRPRLLVWFHGEGWMVGAARTTHRLMCALLAADTGCAVISVDYRLAP
CCHHHHHCCCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCCEEEEEEEEECC
EHPFPAPTDDARDALAYLAEQRLHLSLDPDFLAVGGDSAGGHLAAQAAQAVHDRVRQGLV
CCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
TAQLLVCPATMPAFGSESYSAFAQGPGLTRDEMRWYWAQFIGEAALDRPLAEQDARLFLM
HHHHHEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
ADPPAHLPPDTVVIVAAHDVLRDDGLAYADHLVQHGAQVVTIEASGMTHGFARLQPEAER
ECCCCCCCCCCEEEEEEHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCHHHH
AREWMRRAAHAFVGMIGGDAAG
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]