Click here to switch to the map view.

The map label for this gene is accC1 [H]

Identifier: 17547506

GI number: 17547506

Start: 2997201

End: 2998571

Strand: Direct

Name: accC1 [H]

Synonym: RSc2787

Alternate gene names: 17547506

Gene position: 2997201-2998571 (Clockwise)

Preceding gene: 17547505

Following gene: 17547507

Centisome position: 80.65

GC content: 66.01

Gene sequence:

>1371_bases
ATGTTCGACAAGATCCTGATCGCGAATCGCGGCGAGATCGCGCTTCGCATCCAGCGAGCCTGCCGCGAACTCGGCATCAA
GACCGTGGTGGTCTATTCCGAGGCGGACAAGGAAGCCAAGTACGTCAAGCTGGCCGATGAGGCCGTCTGTATCGGCCCGG
CGCCGTCGCCGCTGTCGTACCTGAACATGCCGGCCATCATCTCGGCCGCCGAAGTGACCGACGCCCAGGCCATCCACCCC
GGCTACGGCTTCCTGTCGGAGAACGCCGATTTCGCCGAGCGCGTGGAGCAGTCCGGCTTCACCTTCATCGGCCCGACGCC
CGACTGCATCCGCCTGATGGGCGACAAGGTCTCGGCCAAGCAGGCCATGATCAAGTCCGGCGTGCCGTGCGTGCCGGGCT
CGGAGGGCGCGCTGCCCGACGACCCGAAGGAAATCCTGGCGACCGCCCGCAAGGTCGGCTACCCGGTCATCATCAAGGCC
GCGGGCGGCGGCGGCGGCCGCGGCATGCGCGTGGTCCACACCGAGGCCGCGCTGATCAACGCCGTCAACATGACGCGTGA
AGAAGCCGGCCGTGCCTTCGGCAACCCGGAAGTCTATATGGAGAAGTTCCTGGAGAATCCGCGCCACGTGGAGATCCAGG
TCCTGGCCGACCAGCACCGCAACGCCATCTGGCTGGGCGAGCGCGACTGCTCGATGCAGCGCCGCCACCAGAAGGTGATC
GAGGAAGCGCCGGCACCGCACATCCCGCGCCGCCTGATCGAGCGCATCGGCGACCGCTGCGCCGATGCCTGCAAGAAGAT
CGGCTACCGCGGCGCCGGCACGTTCGAGTTCCTGTACGAGAACGGCGAGTTCTACTTCATCGAGATGAACACGCGCGTGC
AGGTCGAGCACCCGGTCACGGAAATGATCACCGGCATCGACATCGTGCAGGAGCAGATCCGCGTGGCAGCCAATGAAAAG
TTGCGCTTCCGCCAGAAGGACGTCGTCCTGAAGGGTCACGCCATCGAGTGCCGCATCAACGCCGAGGATCCGTACAAGTT
CACGCCGTCCCCCGGCCGCATCACGTCGTGGCACGTGCCGGGCGGCCCCGGCATCCGTGTGGATTCGCACGCCTACAACG
GCTATTTCGTGCCGCCCAACTACGACTCGATGATCGGCAAGGTGATCTCGTACGGCACCACGCGCGAGCAGGCCATCGCC
CGCATGCGCATCGCCCTGTCGGAGATGGTGGTCGAAGGCATCCAGACCAACGTGCCCCTGCACCGCGACCTGATGCTCGA
CGCCAACTTCGTCGAAGGCGGCACCAGCATCCACTACCTGGAGCACCGCCTGGCGCAGCAGGAAGTGGCCAAGGGCGGCG
GCAAGGCCTGA

Upstream 100 bases:

>100_bases
CCTGTCCTGCCGCATCCGAGTGCGATCCGGCGCGCGGACCCCAAGAAGAACACGGTCCGGCCAACGCGCCCTCGCCTCCC
CCTTTTGTAGCGAGAACACG

Downstream 100 bases:

>100_bases
GCGGAACCGGACCCATGACCTACCGCGAATGCGTGCTGGAAGTCGCGCGCGACGATGCCGAGGCGCTGTCCGAGGCGTTG
TTCGACCTGGGTGCGCTGTC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MFDKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSYLNMPAIISAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFTFIGPTPDCIRLMGDKVSAKQAMIKSGVPCVPGSEGALPDDPKEILATARKVGYPVIIKA
AGGGGGRGMRVVHTEAALINAVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQVLADQHRNAIWLGERDCSMQRRHQKVI
EEAPAPHIPRRLIERIGDRCADACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGIDIVQEQIRVAANEK
LRFRQKDVVLKGHAIECRINAEDPYKFTPSPGRITSWHVPGGPGIRVDSHAYNGYFVPPNYDSMIGKVISYGTTREQAIA
RMRIALSEMVVEGIQTNVPLHRDLMLDANFVEGGTSIHYLEHRLAQQEVAKGGGKA

Sequences:

>Translated_456_residues
MFDKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSYLNMPAIISAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFTFIGPTPDCIRLMGDKVSAKQAMIKSGVPCVPGSEGALPDDPKEILATARKVGYPVIIKA
AGGGGGRGMRVVHTEAALINAVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQVLADQHRNAIWLGERDCSMQRRHQKVI
EEAPAPHIPRRLIERIGDRCADACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGIDIVQEQIRVAANEK
LRFRQKDVVLKGHAIECRINAEDPYKFTPSPGRITSWHVPGGPGIRVDSHAYNGYFVPPNYDSMIGKVISYGTTREQAIA
RMRIALSEMVVEGIQTNVPLHRDLMLDANFVEGGTSIHYLEHRLAQQEVAKGGGKA
>Mature_456_residues
MFDKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSYLNMPAIISAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFTFIGPTPDCIRLMGDKVSAKQAMIKSGVPCVPGSEGALPDDPKEILATARKVGYPVIIKA
AGGGGGRGMRVVHTEAALINAVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQVLADQHRNAIWLGERDCSMQRRHQKVI
EEAPAPHIPRRLIERIGDRCADACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGIDIVQEQIRVAANEK
LRFRQKDVVLKGHAIECRINAEDPYKFTPSPGRITSWHVPGGPGIRVDSHAYNGYFVPPNYDSMIGKVISYGTTREQAIA
RMRIALSEMVVEGIQTNVPLHRDLMLDANFVEGGTSIHYLEHRLAQQEVAKGGGKA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.0812641083521, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.0812641083521, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.0812641083521, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=46.5909090909091, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=44.9438202247191, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=44.9438202247191, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=44.9438202247191, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI38679977, Length=516, Percent_Identity=31.5891472868217, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI38679967, Length=516, Percent_Identity=31.5891472868217, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI38679971, Length=516, Percent_Identity=31.5891472868217, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679960, Length=516, Percent_Identity=31.5891472868217, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679974, Length=516, Percent_Identity=31.5891472868217, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI134142062, Length=517, Percent_Identity=30.9477756286267, Blast_Score=229, Evalue=6e-60,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=68.75, Blast_Score=609, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.1783295711061, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=46.8181818181818, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=43.6241610738255, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI133931226, Length=497, Percent_Identity=29.9798792756539, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=28.7937743190661, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=28.7937743190661, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.8893905191874, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=44.8660714285714, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.7589285714286, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=30.7400379506641, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=475, Percent_Identity=32, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=46.1711711711712, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651757, Length=426, Percent_Identity=45.3051643192488, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=389, Percent_Identity=44.4730077120823, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24586458, Length=511, Percent_Identity=30.5283757338552, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=30.5283757338552, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=30.5283757338552, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI161076409, Length=511, Percent_Identity=30.5283757338552, Blast_Score=221, Evalue=8e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50367; Mature: 50367

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEEECCCCCCHHH
LNMPAIISAAEVTDAQAIHPGYGFLSENADFAERVEQSGFTFIGPTPDCIRLMGDKVSAK
CCCCHHEEHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCCHHHH
QAMIKSGVPCVPGSEGALPDDPKEILATARKVGYPVIIKAAGGGGGRGMRVVHTEAALIN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQVLADQHRNAIWLGERDCSMQRRHQKVI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPHIPRRLIERIGDRCADACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGIDIVQEQIRVAANEKLRFRQKDVVLKGHAIECRINAEDPYKFTPSPGRITSWHVP
HHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCEEEEEECCCCCCEECCCCCCEEEEECC
GGPGIRVDSHAYNGYFVPPNYDSMIGKVISYGTTREQAIARMRIALSEMVVEGIQTNVPL
CCCCCEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRDLMLDANFVEGGTSIHYLEHRLAQQEVAKGGGKA
CCEEEEECEECCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFDKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEEECCCCCCHHH
LNMPAIISAAEVTDAQAIHPGYGFLSENADFAERVEQSGFTFIGPTPDCIRLMGDKVSAK
CCCCHHEEHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCCHHHH
QAMIKSGVPCVPGSEGALPDDPKEILATARKVGYPVIIKAAGGGGGRGMRVVHTEAALIN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQVLADQHRNAIWLGERDCSMQRRHQKVI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPHIPRRLIERIGDRCADACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGIDIVQEQIRVAANEKLRFRQKDVVLKGHAIECRINAEDPYKFTPSPGRITSWHVP
HHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCEEEEEECCCCCCEECCCCCCEEEEECC
GGPGIRVDSHAYNGYFVPPNYDSMIGKVISYGTTREQAIARMRIALSEMVVEGIQTNVPL
CCCCCEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRDLMLDANFVEGGTSIHYLEHRLAQQEVAKGGGKA
CCEEEEECEECCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]