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The map label for this gene is emrA [H]

Identifier: 17547445

GI number: 17547445

Start: 2931981

End: 2933147

Strand: Direct

Name: emrA [H]

Synonym: RSc2726

Alternate gene names: 17547445

Gene position: 2931981-2933147 (Clockwise)

Preceding gene: 17547440

Following gene: 17547446

Centisome position: 78.89

GC content: 71.64

Gene sequence:

>1167_bases
ATGACCGAGGCCATGGAGCAGCACCAAGACATGGAGCGTCCCACCCATCACGGTGGCGCGGGCACAGCGCCCGCTCAACC
CGCCAGGCGCCTGCGCGGCCGCCCCAGGCGGGTCGCGATGGGCATCGCCGCCCTCGCGCTGCTGGGCGCGGCGGGCGGGT
TGGCCCACTACGAACTGCGCGGCAAGTACGTCGAGGACACGGACGATGCCTACATCCAGGCCGACATCGTCACGGTGGCG
CCCAAGGTCTCGGGCTATGTCGAGCGGGTCGATGTCGCCAACAACCAGGAGGTCCGGGCCGGGCAGCGCCTGCTGCGCAT
CGACCCGCGCGAGTACGCGGCCCAGCTGGCGCAGTACCAGGCCCAGGTGGAGGCGGCCAATGCCAGCGCCGACAACGCCC
GCGCCCAGTTGGCGACGCAGAAGGCCTCCATCGCCCAGGCCCAGGCGCAATTGCAGTCCGCCGAACACGATGCGCAGTTC
ACCGCCGCGCAGACGCAGCGGTACGCATCGCTGGTCGCCTCGGGCGCGGAAACGCGCGACCGGCTGAGCACCCTGCAGAA
CCAGGCGGCGCAGGCCCGCGCGAACGCGCAGGCACAGCGCGCGGCCCTGACCAAGGCAACACTGGAGATCGCCGCGCTCC
AGGCCCAGCTGCGGCAAGCCGAGGCGCAGGCGAAAACGGCGCGCGCGCAGGCAGCGGTGGCCGAGGTCAACCTGGCCGCG
ACCGAGCTGCGCGCCAGCACCGATGGCCGCGTCGGCGACAGCCAGGTCCGCGCCGGGCAGTTCGTGTCCGCCGGCACGCG
CCTGATGTCGGTCGTGCCCATGCACCTCTACATCACCGCCAACTTCAAGGAAACGCAGCTGGGCCGCATGCGCATCGGCC
AACCGGTGCACATCCACGTCGATGCGTTCCCCGACGAAGCGATCGAGGGGCACGTCGAAAGCCTGTCCCCCGGCACCGGC
GCGCAGTTCTCGCTGCTGCCGCCGCAGAACGCCACCGGCAACTTCATCAAGATCGTGCAGCGCGTGCCGGTGCGGATCGC
GCTCGACGTGACCGACCGGCTCAAGCCGCTGCTGGCGGCCGGCATGTCGGTCACGGTCGATGTCGATACGCTCGCGCCGG
TCCGGCCCGCGGCGCACCCGCAGCCGGGCAGCGGAGCCCTTCTGTGA

Upstream 100 bases:

>100_bases
CCGGATCGTCGATGACTGCCGACATACATTCATCCCAATATGATATGGTAGTGAAATTATATAGGCGAACCCGGGTTCGC
GCACGAAGAGGATCGTCAGC

Downstream 100 bases:

>100_bases
CGGCGAACGGATCGCGGGCGGATGCCGCGGCCTGGGCGGCCGTCGCGGCCGGCACCCTCGGCGCCATGATGGCCACGCTC
GACATCTCCATCGTGAATTC

Product: multidrug ABC transporter transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTEAMEQHQDMERPTHHGGAGTAPAQPARRLRGRPRRVAMGIAALALLGAAGGLAHYELRGKYVEDTDDAYIQADIVTVA
PKVSGYVERVDVANNQEVRAGQRLLRIDPREYAAQLAQYQAQVEAANASADNARAQLATQKASIAQAQAQLQSAEHDAQF
TAAQTQRYASLVASGAETRDRLSTLQNQAAQARANAQAQRAALTKATLEIAALQAQLRQAEAQAKTARAQAAVAEVNLAA
TELRASTDGRVGDSQVRAGQFVSAGTRLMSVVPMHLYITANFKETQLGRMRIGQPVHIHVDAFPDEAIEGHVESLSPGTG
AQFSLLPPQNATGNFIKIVQRVPVRIALDVTDRLKPLLAAGMSVTVDVDTLAPVRPAAHPQPGSGALL

Sequences:

>Translated_388_residues
MTEAMEQHQDMERPTHHGGAGTAPAQPARRLRGRPRRVAMGIAALALLGAAGGLAHYELRGKYVEDTDDAYIQADIVTVA
PKVSGYVERVDVANNQEVRAGQRLLRIDPREYAAQLAQYQAQVEAANASADNARAQLATQKASIAQAQAQLQSAEHDAQF
TAAQTQRYASLVASGAETRDRLSTLQNQAAQARANAQAQRAALTKATLEIAALQAQLRQAEAQAKTARAQAAVAEVNLAA
TELRASTDGRVGDSQVRAGQFVSAGTRLMSVVPMHLYITANFKETQLGRMRIGQPVHIHVDAFPDEAIEGHVESLSPGTG
AQFSLLPPQNATGNFIKIVQRVPVRIALDVTDRLKPLLAAGMSVTVDVDTLAPVRPAAHPQPGSGALL
>Mature_387_residues
TEAMEQHQDMERPTHHGGAGTAPAQPARRLRGRPRRVAMGIAALALLGAAGGLAHYELRGKYVEDTDDAYIQADIVTVAP
KVSGYVERVDVANNQEVRAGQRLLRIDPREYAAQLAQYQAQVEAANASADNARAQLATQKASIAQAQAQLQSAEHDAQFT
AAQTQRYASLVASGAETRDRLSTLQNQAAQARANAQAQRAALTKATLEIAALQAQLRQAEAQAKTARAQAAVAEVNLAAT
ELRASTDGRVGDSQVRAGQFVSAGTRLMSVVPMHLYITANFKETQLGRMRIGQPVHIHVDAFPDEAIEGHVESLSPGTGA
QFSLLPPQNATGNFIKIVQRVPVRIALDVTDRLKPLLAAGMSVTVDVDTLAPVRPAAHPQPGSGALL

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=342, Percent_Identity=32.7485380116959, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789041, Length=364, Percent_Identity=33.2417582417582, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1790519, Length=298, Percent_Identity=33.2214765100671, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI87081951, Length=315, Percent_Identity=28.2539682539683, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790024, Length=252, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790012, Length=252, Percent_Identity=25.7936507936508, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789900, Length=319, Percent_Identity=26.3322884012539, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41277; Mature: 41146

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAMEQHQDMERPTHHGGAGTAPAQPARRLRGRPRRVAMGIAALALLGAAGGLAHYELR
CCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEC
GKYVEDTDDAYIQADIVTVAPKVSGYVERVDVANNQEVRAGQRLLRIDPREYAAQLAQYQ
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCCHHHHCCHHEEECHHHHHHHHHHHH
AQVEAANASADNARAQLATQKASIAQAQAQLQSAEHDAQFTAAQTQRYASLVASGAETRD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
RLSTLQNQAAQARANAQAQRAALTKATLEIAALQAQLRQAEAQAKTARAQAAVAEVNLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TELRASTDGRVGDSQVRAGQFVSAGTRLMSVVPMHLYITANFKETQLGRMRIGQPVHIHV
HHHHCCCCCCCCCHHHHCCHHHHHHHHHHHEEEEEEEEEECCCHHHHHHHHCCCEEEEEE
DAFPDEAIEGHVESLSPGTGAQFSLLPPQNATGNFIKIVQRVPVRIALDVTDRLKPLLAA
ECCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHC
GMSVTVDVDTLAPVRPAAHPQPGSGALL
CCEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEAMEQHQDMERPTHHGGAGTAPAQPARRLRGRPRRVAMGIAALALLGAAGGLAHYELR
CCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEC
GKYVEDTDDAYIQADIVTVAPKVSGYVERVDVANNQEVRAGQRLLRIDPREYAAQLAQYQ
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCCHHHHCCHHEEECHHHHHHHHHHHH
AQVEAANASADNARAQLATQKASIAQAQAQLQSAEHDAQFTAAQTQRYASLVASGAETRD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
RLSTLQNQAAQARANAQAQRAALTKATLEIAALQAQLRQAEAQAKTARAQAAVAEVNLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TELRASTDGRVGDSQVRAGQFVSAGTRLMSVVPMHLYITANFKETQLGRMRIGQPVHIHV
HHHHCCCCCCCCCHHHHCCHHHHHHHHHHHEEEEEEEEEECCCHHHHHHHHCCCEEEEEE
DAFPDEAIEGHVESLSPGTGAQFSLLPPQNATGNFIKIVQRVPVRIALDVTDRLKPLLAA
ECCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHC
GMSVTVDVDTLAPVRPAAHPQPGSGALL
CCEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]