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The map label for this gene is holB [H]

Identifier: 17546504

GI number: 17546504

Start: 1920565

End: 1921575

Strand: Direct

Name: holB [H]

Synonym: RSc1785

Alternate gene names: 17546504

Gene position: 1920565-1921575 (Clockwise)

Preceding gene: 17546503

Following gene: 17546505

Centisome position: 51.68

GC content: 68.94

Gene sequence:

>1011_bases
ATGATGCTTTATCCATGGCAATCCGCTGACTGGACGCGCCTGCAGGCCATGCGGGCCAAGCTGCCGCACGCCATCCTGCT
CAGCGGCCAGGCCGGCACCGGCAAGCGCGATTTCGCCATGCACTTCGCGCAGGGGCTGCTGTGCGACACGCCCACCGCCG
ACGGCCGGCCGTGCCAGACCTGCGCCGCCTGCAACTGGTTCGCGCAGGGCAACCACCCGGACTTCCACCTGGTGCGTCCC
GAGGCGATGGAAGACTCGCCCGACACCGAAAAGGATGCCGAAGGCAAGAAGAAGGCGCCCAGCAAGATCATCCGCATGGA
GCAGGTGCGGCAGCTGATCGAGGCCATCGGGGTCGGCACGCACCGGGCCGGGCTGCGCGTGGTGGTGCTGTATCCCCTCG
ATGCGCTGCAGACCGAGGGCGCCAATGCGCTGCTGAAGACGCTGGAGGAGCCGCCGCAGGACACCGTTTTCCTGCTGGTG
ACGGACCGCATCGACCGCATCCTGCCGACCATCCTGTCGCGCTGCCGGCAATTTCCGTTGCAGCCGCCGCAGCCCGAGGC
CGCCCGGCAGTGGCTGGAGGGGCAGGGCGTGCCGCACGCGCAAAGCCTGCTGGCGGAATTCGGCAACGCGCCGCTGGCCG
CACTGCAGGCCGCCGAATCGGAAGAGCGTCCGCTGCTGCAATTCCTGCTGGAACAGCTGGCCCAGGGCGCCAGGCTGGAT
GCGCTGGCAACGGCCGACCACCTGCAGAAATTGTCGGTTCCGGCGGTTCTCAGTACCATGCACCGGTGGATCTTCGATCT
GATGGCGGCGAGACTGGCGGGCCGTCCGCGGTATTTCCCCGCGCAGCGCGATGCCCTGCTGCGCTGCGCGGGCGCCATCC
CGCTGGAGCGCCTGGAGCGGTTCGCGCGGGCCTTGCCCGAGCGGCGGCGCACCGAACAGCACCCGCTGGCCGCGCGGGTC
GTCATCGAAAGCCTTTTGCTGGATTACCGGCAGCTCTTTCCGGCTGCCTGA

Upstream 100 bases:

>100_bases
ACTGCTTGCAAGCCTTTGATGCCGCAGGCAATTTCGGTCACCGAAATAATGGTTCCACGGCAAGATTCTGCTTGAAGAGT
CCTGCGCAACCCATTGATGC

Downstream 100 bases:

>100_bases
ACTTCAACGTTTGGAACCTCTGTGAGCACTGCACCTATCCGTACCCCGGGCACGCCCGGCATGCCGGCCGCCCCCGGCAC
TCCCGCCGCACCGGGCATGG

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MMLYPWQSADWTRLQAMRAKLPHAILLSGQAGTGKRDFAMHFAQGLLCDTPTADGRPCQTCAACNWFAQGNHPDFHLVRP
EAMEDSPDTEKDAEGKKKAPSKIIRMEQVRQLIEAIGVGTHRAGLRVVVLYPLDALQTEGANALLKTLEEPPQDTVFLLV
TDRIDRILPTILSRCRQFPLQPPQPEAARQWLEGQGVPHAQSLLAEFGNAPLAALQAAESEERPLLQFLLEQLAQGARLD
ALATADHLQKLSVPAVLSTMHRWIFDLMAARLAGRPRYFPAQRDALLRCAGAIPLERLERFARALPERRRTEQHPLAARV
VIESLLLDYRQLFPAA

Sequences:

>Translated_336_residues
MMLYPWQSADWTRLQAMRAKLPHAILLSGQAGTGKRDFAMHFAQGLLCDTPTADGRPCQTCAACNWFAQGNHPDFHLVRP
EAMEDSPDTEKDAEGKKKAPSKIIRMEQVRQLIEAIGVGTHRAGLRVVVLYPLDALQTEGANALLKTLEEPPQDTVFLLV
TDRIDRILPTILSRCRQFPLQPPQPEAARQWLEGQGVPHAQSLLAEFGNAPLAALQAAESEERPLLQFLLEQLAQGARLD
ALATADHLQKLSVPAVLSTMHRWIFDLMAARLAGRPRYFPAQRDALLRCAGAIPLERLERFARALPERRRTEQHPLAARV
VIESLLLDYRQLFPAA
>Mature_336_residues
MMLYPWQSADWTRLQAMRAKLPHAILLSGQAGTGKRDFAMHFAQGLLCDTPTADGRPCQTCAACNWFAQGNHPDFHLVRP
EAMEDSPDTEKDAEGKKKAPSKIIRMEQVRQLIEAIGVGTHRAGLRVVVLYPLDALQTEGANALLKTLEEPPQDTVFLLV
TDRIDRILPTILSRCRQFPLQPPQPEAARQWLEGQGVPHAQSLLAEFGNAPLAALQAAESEERPLLQFLLEQLAQGARLD
ALATADHLQKLSVPAVLSTMHRWIFDLMAARLAGRPRYFPAQRDALLRCAGAIPLERLERFARALPERRRTEQHPLAARV
VIESLLLDYRQLFPAA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=175, Percent_Identity=33.7142857142857, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787341, Length=197, Percent_Identity=32.994923857868, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003959
- InterPro:   IPR004622 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37498; Mature: 37498

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLYPWQSADWTRLQAMRAKLPHAILLSGQAGTGKRDFAMHFAQGLLCDTPTADGRPCQT
CEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHH
CAACNWFAQGNHPDFHLVRPEAMEDSPDTEKDAEGKKKAPSKIIRMEQVRQLIEAIGVGT
HHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
HRAGLRVVVLYPLDALQTEGANALLKTLEEPPQDTVFLLVTDRIDRILPTILSRCRQFPL
CCCCCEEEEEECCHHHHCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCC
QPPQPEAARQWLEGQGVPHAQSLLAEFGNAPLAALQAAESEERPLLQFLLEQLAQGARLD
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHH
ALATADHLQKLSVPAVLSTMHRWIFDLMAARLAGRPRYFPAQRDALLRCAGAIPLERLER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHH
FARALPERRRTEQHPLAARVVIESLLLDYRQLFPAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMLYPWQSADWTRLQAMRAKLPHAILLSGQAGTGKRDFAMHFAQGLLCDTPTADGRPCQT
CEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHH
CAACNWFAQGNHPDFHLVRPEAMEDSPDTEKDAEGKKKAPSKIIRMEQVRQLIEAIGVGT
HHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
HRAGLRVVVLYPLDALQTEGANALLKTLEEPPQDTVFLLVTDRIDRILPTILSRCRQFPL
CCCCCEEEEEECCHHHHCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCC
QPPQPEAARQWLEGQGVPHAQSLLAEFGNAPLAALQAAESEERPLLQFLLEQLAQGARLD
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHH
ALATADHLQKLSVPAVLSTMHRWIFDLMAARLAGRPRYFPAQRDALLRCAGAIPLERLER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHH
FARALPERRRTEQHPLAARVVIESLLLDYRQLFPAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550441; 10984043 [H]