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The map label for this gene is tmk

Identifier: 17546503

GI number: 17546503

Start: 1919866

End: 1920483

Strand: Direct

Name: tmk

Synonym: RSc1784

Alternate gene names: 17546503

Gene position: 1919866-1920483 (Clockwise)

Preceding gene: 17546502

Following gene: 17546504

Centisome position: 51.66

GC content: 70.23

Gene sequence:

>618_bases
ATGACCGGCAAGTTCATCACATTCGAAGGCATCGACGGCGCGGGCAAGAGCACGCACCTGGCGTGGTTCGCCCAGCAGCT
CGAAGCGCGGCTGGCGCCGCAGGGCAGGAAGGTGGTGGTGACCCGCGAGCCGGGCGGCACGCCGCTGGGCGAGCGCCTGC
GCGAAGTGCTGCTGCACGAGCGCATGCACCTGGAGACCGAGGCGCTGCTGATGTTCGCCAGCCGCCGGGAGCACATCGCC
GAAGTGATTCAGCCGGCGCTGGAGCGCGGCGACTGGGTCATCTCCGACCGCTTCACCGATGCCACCTTCGCCTACCAGGG
CGGGGGCAGGGGGCTGGCGATCGAGCGGCTGGAGGCGCTGGAGCAGTGGGTGCAGCAGGGCCTGCAGCCGACCAGGACAC
TGCTGTTCGATCTGGCGCCGGAGGTTGCCGCGGCCCGGCTGGCCGATGCGCGCACGCCCGACAAGTTCGAGGCGGAGTCG
GCCCAGTTCTTCGTCCGCACGCGCGCCGAGTACCTGCGCCGCGCCGCCGCCGAACCGGGGCGTTTCGTCGTCATCGACGC
CGCCCGCGCGCGCGACGATATCCGGAAAGACCTGGAGAAACTGCTTGCAAGCCTTTGA

Upstream 100 bases:

>100_bases
ATGCGCTGTACTTCGTCGCGCGCGGCGACGGCACCAGCCAGTTCTCGACCAACCTCACGGACCACAACCGGGCCGTCAAC
AAATACCAGCGCGGCCAACC

Downstream 100 bases:

>100_bases
TGCCGCAGGCAATTTCGGTCACCGAAATAATGGTTCCACGGCAAGATTCTGCTTGAAGAGTCCTGCGCAACCCATTGATG
CATGATGCTTTATCCATGGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MTGKFITFEGIDGAGKSTHLAWFAQQLEARLAPQGRKVVVTREPGGTPLGERLREVLLHERMHLETEALLMFASRREHIA
EVIQPALERGDWVISDRFTDATFAYQGGGRGLAIERLEALEQWVQQGLQPTRTLLFDLAPEVAAARLADARTPDKFEAES
AQFFVRTRAEYLRRAAAEPGRFVVIDAARARDDIRKDLEKLLASL

Sequences:

>Translated_205_residues
MTGKFITFEGIDGAGKSTHLAWFAQQLEARLAPQGRKVVVTREPGGTPLGERLREVLLHERMHLETEALLMFASRREHIA
EVIQPALERGDWVISDRFTDATFAYQGGGRGLAIERLEALEQWVQQGLQPTRTLLFDLAPEVAAARLADARTPDKFEAES
AQFFVRTRAEYLRRAAAEPGRFVVIDAARARDDIRKDLEKLLASL
>Mature_204_residues
TGKFITFEGIDGAGKSTHLAWFAQQLEARLAPQGRKVVVTREPGGTPLGERLREVLLHERMHLETEALLMFASRREHIAE
VIQPALERGDWVISDRFTDATFAYQGGGRGLAIERLEALEQWVQQGLQPTRTLLFDLAPEVAAARLADARTPDKFEAESA
QFFVRTRAEYLRRAAAEPGRFVVIDAARARDDIRKDLEKLLASL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=184, Percent_Identity=41.8478260869565, Blast_Score=120, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_RALSO (Q8XYH4)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519905.1
- ProteinModelPortal:   Q8XYH4
- SMR:   Q8XYH4
- GeneID:   1220622
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1784
- NMPDR:   fig|267608.1.peg.1784
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   RSOL267608:RSC1784-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23010; Mature: 22878

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKFITFEGIDGAGKSTHLAWFAQQLEARLAPQGRKVVVTREPGGTPLGERLREVLLHE
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RMHLETEALLMFASRREHIAEVIQPALERGDWVISDRFTDATFAYQGGGRGLAIERLEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCHHHHHHHHH
EQWVQQGLQPTRTLLFDLAPEVAAARLADARTPDKFEAESAQFFVRTRAEYLRRAAAEPG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
RFVVIDAARARDDIRKDLEKLLASL
CEEEEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGKFITFEGIDGAGKSTHLAWFAQQLEARLAPQGRKVVVTREPGGTPLGERLREVLLHE
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RMHLETEALLMFASRREHIAEVIQPALERGDWVISDRFTDATFAYQGGGRGLAIERLEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCHHHHHHHHH
EQWVQQGLQPTRTLLFDLAPEVAAARLADARTPDKFEAESAQFFVRTRAEYLRRAAAEPG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
RFVVIDAARARDDIRKDLEKLLASL
CEEEEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852