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The map label for this gene is livM [H]

Identifier: 17546471

GI number: 17546471

Start: 1875019

End: 1876341

Strand: Direct

Name: livM [H]

Synonym: RSc1752

Alternate gene names: 17546471

Gene position: 1875019-1876341 (Clockwise)

Preceding gene: 17546470

Following gene: 17546472

Centisome position: 50.45

GC content: 69.77

Gene sequence:

>1323_bases
ATGGACCGCGTCATGTCGCAACAACAGGCGTTGCCCGCCAACGATCGCGCCCGCACGATGCGGTTCAAGCCGCTCAACCT
CGCGCGCTGGCTGATCTGGGGCACCACCGCGCTGGTGATGCTCGTGCTGCCGCTGATCTGGCCGCAGGGCTTCGCCATCA
CGCTGCTCTCGCAGATGGGCATCATGATCATCTTCGCGCTGTCGTACAACATGCTGCTGGGGCAGGCGGGCATGCTGTCG
TTCGGGCACGCGGTGTACGCCGGCCTGGGCGCCTTCGTGGCGGTGCATCTGCTCAACCGGATCGGCGCGGCGCCGGCGCT
CGGCATCGGCGGGCCGCTGGCGGTGGCGCTGCTGCCGGTCGCGGGCGGGCTGGGCGGGGCGCTGTTCGGCGTGCTGTTCG
GTTATGTCACCACCCGGCGGGCCGGCACCACGTTCTCGATGATCACGCTCGGCATCGGCGAGATGGTGTTCGCCAGCGCG
CTGATGCTCCCCGACTTCTTCGGCGGCGAGGGCGGCGTGTCGACCAATCGCAGCATTGGCGAGCCGCTGCTGGGCATCAG
CTTCGGGCTGGCGCGGCAGGTCTACTACCTGATCGCCGTGTGGTGCCTGATCTCGATGGCGCTGATGTACGCCTGGACGC
AGACGCCGCTGGGCCGCCTCGCCAACGCGGTGCGCGACAACCCCGAGCGCGTGGCGTTCGTCGGCTACAACCCGCAGCGG
GTGCGCTACCTGGTGGTGATCCTGTCGGCGTTCTTCGCGGGCATCGCGGGGGCGCTGTCGTGCATCAACTTCGAGATCGT
GACTGCGGAGAACGTGTCGGCGGTGCGTTCGGGGGCGGTGCTGCTGGCGGCCTTCATCGGCGGCATGGGCACGTTCTTCG
GCCCGATCATCGGCGCGGTGCTGACGGTGTTCTTCACGGTGGCGCTGTCCGGCATCACCAAGGCGTGGCTGTTGTACCTG
GGGCTGTTCTTCGTGCTGATGGTGATGTACGCGCCGGGCGGCATCGCCAGCCTGCTGACCATGCATGCGCCGATCCTGCG
GCGCGGCAAGCTGGGGACGCTGTTGCCGGCCTACGGCGTGGCGATCGTGCCGGCGCTGGTGCTGCTGGCCGCGCTGATCG
CCACCGTGGAAATGATCTACGCCGTGCAGGACGACAGCGCGGGTGGCGTGGCGACGCTGTTCGGCTTGTCGGTGCAGCCG
GCCACCTGGACGCCGTGGGCCGTCACCGCCGTGCTGTGGGCGGCGGGCGGGGGCGGCCTGCGCATCGCGGCGGGCCGGCT
GCGCGCCGCCTGGGATCTCGCCTTGCAGGAGCGTCAGCCATGA

Upstream 100 bases:

>100_bases
CATCGCGCAGGTGGCGCCGGTGCTGCCGTACCTGCTGCTGGTGCTGATGCTGATCTTCCGCCCGCGCGGGCTGATGGGCA
CGCGGGAGGGATAAGCGCAA

Downstream 100 bases:

>100_bases
GCCAACCGATTCCCGCGCTGGAACTGCGCGACGTCCGCAAGCGCTTCGGCGCGACCGAAATCATCCGGGGCGTGAACCTG
ACCATCGGCCGCGGCGAGCG

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MDRVMSQQQALPANDRARTMRFKPLNLARWLIWGTTALVMLVLPLIWPQGFAITLLSQMGIMIIFALSYNMLLGQAGMLS
FGHAVYAGLGAFVAVHLLNRIGAAPALGIGGPLAVALLPVAGGLGGALFGVLFGYVTTRRAGTTFSMITLGIGEMVFASA
LMLPDFFGGEGGVSTNRSIGEPLLGISFGLARQVYYLIAVWCLISMALMYAWTQTPLGRLANAVRDNPERVAFVGYNPQR
VRYLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGAVLLAAFIGGMGTFFGPIIGAVLTVFFTVALSGITKAWLLYL
GLFFVLMVMYAPGGIASLLTMHAPILRRGKLGTLLPAYGVAIVPALVLLAALIATVEMIYAVQDDSAGGVATLFGLSVQP
ATWTPWAVTAVLWAAGGGGLRIAAGRLRAAWDLALQERQP

Sequences:

>Translated_440_residues
MDRVMSQQQALPANDRARTMRFKPLNLARWLIWGTTALVMLVLPLIWPQGFAITLLSQMGIMIIFALSYNMLLGQAGMLS
FGHAVYAGLGAFVAVHLLNRIGAAPALGIGGPLAVALLPVAGGLGGALFGVLFGYVTTRRAGTTFSMITLGIGEMVFASA
LMLPDFFGGEGGVSTNRSIGEPLLGISFGLARQVYYLIAVWCLISMALMYAWTQTPLGRLANAVRDNPERVAFVGYNPQR
VRYLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGAVLLAAFIGGMGTFFGPIIGAVLTVFFTVALSGITKAWLLYL
GLFFVLMVMYAPGGIASLLTMHAPILRRGKLGTLLPAYGVAIVPALVLLAALIATVEMIYAVQDDSAGGVATLFGLSVQP
ATWTPWAVTAVLWAAGGGGLRIAAGRLRAAWDLALQERQP
>Mature_440_residues
MDRVMSQQQALPANDRARTMRFKPLNLARWLIWGTTALVMLVLPLIWPQGFAITLLSQMGIMIIFALSYNMLLGQAGMLS
FGHAVYAGLGAFVAVHLLNRIGAAPALGIGGPLAVALLPVAGGLGGALFGVLFGYVTTRRAGTTFSMITLGIGEMVFASA
LMLPDFFGGEGGVSTNRSIGEPLLGISFGLARQVYYLIAVWCLISMALMYAWTQTPLGRLANAVRDNPERVAFVGYNPQR
VRYLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGAVLLAAFIGGMGTFFGPIIGAVLTVFFTVALSGITKAWLLYL
GLFFVLMVMYAPGGIASLLTMHAPILRRGKLGTLLPAYGVAIVPALVLLAALIATVEMIYAVQDDSAGGVATLFGLSVQP
ATWTPWAVTAVLWAAGGGGLRIAAGRLRAAWDLALQERQP

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=308, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 46432; Mature: 46432

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVMSQQQALPANDRARTMRFKPLNLARWLIWGTTALVMLVLPLIWPQGFAITLLSQMG
CCCHHHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IMIIFALSYNMLLGQAGMLSFGHAVYAGLGAFVAVHLLNRIGAAPALGIGGPLAVALLPV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
AGGLGGALFGVLFGYVTTRRAGTTFSMITLGIGEMVFASALMLPDFFGGEGGVSTNRSIG
HCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
EPLLGISFGLARQVYYLIAVWCLISMALMYAWTQTPLGRLANAVRDNPERVAFVGYNPQR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHH
VRYLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGAVLLAAFIGGMGTFFGPIIGAV
HHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTVFFTVALSGITKAWLLYLGLFFVLMVMYAPGGIASLLTMHAPILRRGKLGTLLPAYGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
AIVPALVLLAALIATVEMIYAVQDDSAGGVATLFGLSVQPATWTPWAVTAVLWAAGGGGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCE
RIAAGRLRAAWDLALQERQP
EEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDRVMSQQQALPANDRARTMRFKPLNLARWLIWGTTALVMLVLPLIWPQGFAITLLSQMG
CCCHHHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IMIIFALSYNMLLGQAGMLSFGHAVYAGLGAFVAVHLLNRIGAAPALGIGGPLAVALLPV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
AGGLGGALFGVLFGYVTTRRAGTTFSMITLGIGEMVFASALMLPDFFGGEGGVSTNRSIG
HCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
EPLLGISFGLARQVYYLIAVWCLISMALMYAWTQTPLGRLANAVRDNPERVAFVGYNPQR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHH
VRYLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGAVLLAAFIGGMGTFFGPIIGAV
HHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTVFFTVALSGITKAWLLYLGLFFVLMVMYAPGGIASLLTMHAPILRRGKLGTLLPAYGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
AIVPALVLLAALIATVEMIYAVQDDSAGGVATLFGLSVQPATWTPWAVTAVLWAAGGGGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCE
RIAAGRLRAAWDLALQERQP
EEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]