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The map label for this gene is clpP

Identifier: 17546430

GI number: 17546430

Start: 1828245

End: 1828898

Strand: Direct

Name: clpP

Synonym: RSc1711

Alternate gene names: 17546430

Gene position: 1828245-1828898 (Clockwise)

Preceding gene: 17546429

Following gene: 17546431

Centisome position: 49.19

GC content: 63.61

Gene sequence:

>654_bases
ATGATCCGCAATGAACTGATCGACCAACTCGCCCGCACCCAGGCTTCCGCGCTTGAAACGCAGGGCCTCGGACTGGTGCC
GATGGTGGTCGAGCAGTCGGGCCGCGGCGAACGCGCCTACGACATCTACTCGCGTCTGCTCAAGGAGCGCGTGATTTTCA
TGGTGGGCGAGGTCAACGACCAGACTGCCAATCTCGTGGTGGCGCAGTTGCTGTTCCTGGAGAGCGAGAATCCGGACAAG
GACATCTCGCTGTACATCAACTCGCCGGGCGGTTCGGTGTCGGCGGGCCTGGCGATGTACGACACGATGCAGTTTGTCAA
GCCCGACGTGTCCACGTTGTGCATGGGCATGGCCGCCAGCATGGGCGCGTTCCTGCTGGCCGCCGGCGCGAAGGGCAAGC
GCTATGCGCTGCCGAACTCGCGGATCATGATTCACCAGCCGCTGGGCGGTGCGCGCGGCCAGGCCTCGGATATCGAGATC
CAGGCGCGTGAAATCCTGTACCTGCGCGAACGTCTGAACACGATCCTGTCCGAAGTCACCGGCCAGCCCGTGGACAAGAT
CGCCCGCGATACGGACCGCGACAATTTCATGAGCGGCGATCAGGCCAAGGAGTACGGCCTGATCGACAAGGTGCTGGCTC
GGCGGGGTGCCTGA

Upstream 100 bases:

>100_bases
ACAAGGCCAAGGTCGCTGACAAAGCCATGTCGTTCGAAGAGCTGACCGCCACCCAGGGCGCGCAAGGCTGATTCGACCGA
TCCACGCACCGGAGAACCGC

Downstream 100 bases:

>100_bases
ACACCCTGTGGCCGGTGCGCCGGACGGCACACCGGTCGCAGCGTGCCGGACGTCTCAAGCTGTCAAAGACGAGGCCTCGC
GCCTCGTTTTTGCTATGTGC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSAGLAMYDTMQFVKPDVSTLCMGMAASMGAFLLAAGAKGKRYALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNTILSEVTGQPVDKIARDTDRDNFMSGDQAKEYGLIDKVLARRGA

Sequences:

>Translated_217_residues
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSAGLAMYDTMQFVKPDVSTLCMGMAASMGAFLLAAGAKGKRYALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNTILSEVTGQPVDKIARDTDRDNFMSGDQAKEYGLIDKVLARRGA
>Mature_217_residues
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSAGLAMYDTMQFVKPDVSTLCMGMAASMGAFLLAAGAKGKRYALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNTILSEVTGQPVDKIARDTDRDNFMSGDQAKEYGLIDKVLARRGA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=198, Percent_Identity=57.5757575757576, Blast_Score=242, Evalue=2e-64,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=67.3575129533679, Blast_Score=293, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=53.125, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=58.421052631579, Blast_Score=240, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_RALSO (Q8XYP7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519832.1
- ProteinModelPortal:   Q8XYP7
- SMR:   Q8XYP7
- MEROPS:   S14.001
- GeneID:   1220547
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1711
- NMPDR:   fig|267608.1.peg.1711
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   RSOL267608:RSC1711-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23757; Mature: 23757

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 120-120 ACT_SITE 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVND
CCHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCC
QTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGLAMYDTMQFVKPDVSTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRYALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNTILSEVT
HHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVDKIARDTDRDNFMSGDQAKEYGLIDKVLARRGA
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVND
CCHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCC
QTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGLAMYDTMQFVKPDVSTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRYALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNTILSEVT
HHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVDKIARDTDRDNFMSGDQAKEYGLIDKVLARRGA
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852