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The map label for this gene is infC

Identifier: 17546297

GI number: 17546297

Start: 1694462

End: 1694998

Strand: Direct

Name: infC

Synonym: RSc1578

Alternate gene names: 17546297

Gene position: 1694462-1694998 (Clockwise)

Preceding gene: 17546296

Following gene: 17546298

Centisome position: 45.59

GC content: 58.47

Gene sequence:

>537_bases
TTGAGGACATTCAACATCGCTACTGAGAAATCTCACCGCATCAACCGCGAGATCACCGCGCCGGAAATCCGGCTGACCGG
GGTTGAAGGGGAACAGCTCGGCATCGTCAAACTGTTCGACGCACTGCGTCTGGCAGAAGAGAAGGACGTCGACCTGGTCG
AGATCGCGCCGACCGCGCAGCCGCCTGTCTGCCGCCTGATGGACTATGGCAAGTTCAAGTATCAGGAACAGAAGAAGGCC
CACGAGGCCAAGCTGAAGCAGAAGGTCATCCAGGTGAAGGAAGTGAAATTCCGCCCTGGTACCGACGACGGCGACTACGA
GGTCAAGCTGCGCAATCTCAAGCGCTTCCTGGATGAAGGTGATCGCACCAAGATCACGCTGCGCTTCCGGGGCCGCGAGA
TGGCGCACCAGGAAATCGGCGCACGCATGCTCGATCGTCTGAAGACGGACTTGGAAGAGTTCGGCCAAGTCGAGCAGATG
CCGAAGATGGAAGGTCGCCAGATGGTGATGATGTTGGCGCCGAAGAAGCGCAAGTGA

Upstream 100 bases:

>100_bases
CGTCGATCTCGGTTCGATGCCGGTATCCACGTTCGTTGAGCGACTGCAGAACGATTTCGCCAACAAGTCATGAGCTGGGC
ACGGCTTGTTTTTTGCTTCT

Downstream 100 bases:

>100_bases
TACGGGCAGCGGCCGGAGGCACTCCGGCCGCTGCCCAGCATTTCGGACAGAAGCAGGTTGTCGCGCGTCGGCGGCATGCG
AAGTCGGAAAGCGCGGCGGG

Product: translation initiation factor IF-3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MRTFNIATEKSHRINREITAPEIRLTGVEGEQLGIVKLFDALRLAEEKDVDLVEIAPTAQPPVCRLMDYGKFKYQEQKKA
HEAKLKQKVIQVKEVKFRPGTDDGDYEVKLRNLKRFLDEGDRTKITLRFRGREMAHQEIGARMLDRLKTDLEEFGQVEQM
PKMEGRQMVMMLAPKKRK

Sequences:

>Translated_178_residues
MRTFNIATEKSHRINREITAPEIRLTGVEGEQLGIVKLFDALRLAEEKDVDLVEIAPTAQPPVCRLMDYGKFKYQEQKKA
HEAKLKQKVIQVKEVKFRPGTDDGDYEVKLRNLKRFLDEGDRTKITLRFRGREMAHQEIGARMLDRLKTDLEEFGQVEQM
PKMEGRQMVMMLAPKKRK
>Mature_178_residues
MRTFNIATEKSHRINREITAPEIRLTGVEGEQLGIVKLFDALRLAEEKDVDLVEIAPTAQPPVCRLMDYGKFKYQEQKKA
HEAKLKQKVIQVKEVKFRPGTDDGDYEVKLRNLKRFLDEGDRTKITLRFRGREMAHQEIGARMLDRLKTDLEEFGQVEQM
PKMEGRQMVMMLAPKKRK

Specific function: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins

COG id: COG0290

COG function: function code J; Translation initiation factor 3 (IF-3)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-3 family

Homologues:

Organism=Escherichia coli, GI1788012, Length=174, Percent_Identity=66.6666666666667, Blast_Score=223, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF3_RALSO (Q8XZ28)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519699.1
- ProteinModelPortal:   Q8XZ28
- GeneID:   1220410
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1578
- NMPDR:   fig|267608.1.peg.1578
- HOGENOM:   HBG744268
- OMA:   APKAPIN
- ProtClustDB:   PRK00028
- BioCyc:   RSOL267608:RSC1578-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00080
- InterPro:   IPR019813
- InterPro:   IPR001288
- InterPro:   IPR019815
- InterPro:   IPR019814
- Gene3D:   G3DSA:3.10.20.80
- Gene3D:   G3DSA:3.30.110.10
- PANTHER:   PTHR10938
- TIGRFAMs:   TIGR00168

Pfam domain/function: PF00707 IF3_C; PF05198 IF3_N; SSF54364 IF3; SSF55200 IF3

EC number: NA

Molecular weight: Translated: 20801; Mature: 20801

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00938 IF3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTFNIATEKSHRINREITAPEIRLTGVEGEQLGIVKLFDALRLAEEKDVDLVEIAPTAQ
CCCCCCCCCCCHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
PPVCRLMDYGKFKYQEQKKAHEAKLKQKVIQVKEVKFRPGTDDGDYEVKLRNLKRFLDEG
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEHHHHHHHHHCCC
DRTKITLRFRGREMAHQEIGARMLDRLKTDLEEFGQVEQMPKMEGRQMVMMLAPKKRK
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MRTFNIATEKSHRINREITAPEIRLTGVEGEQLGIVKLFDALRLAEEKDVDLVEIAPTAQ
CCCCCCCCCCCHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
PPVCRLMDYGKFKYQEQKKAHEAKLKQKVIQVKEVKFRPGTDDGDYEVKLRNLKRFLDEG
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEHHHHHHHHHCCC
DRTKITLRFRGREMAHQEIGARMLDRLKTDLEEFGQVEQMPKMEGRQMVMMLAPKKRK
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852