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The map label for this gene is lepB [H]

Identifier: 17545780

GI number: 17545780

Start: 1115188

End: 1116105

Strand: Direct

Name: lepB [H]

Synonym: RSc1061

Alternate gene names: 17545780

Gene position: 1115188-1116105 (Clockwise)

Preceding gene: 17545779

Following gene: 17545781

Centisome position: 30.01

GC content: 60.78

Gene sequence:

>918_bases
ATGAACTTCGCCCTGATCCTTTTCATTCTCGTCGTCTTCACCGGTGTGGCGTGGGTGGCCGACAAGCTGATGTTCCAGCG
CCAACGCCAGGCCGCCGCCACGGCCGCGCTGGCCGAGTTCGACGCCCGTGCCCAGGCCCAGGTGCAGTATGGTGCCGTGG
CCGACGTGGGCGCGGCGCGCGCGCAGCTGGCCGAAGAGACGCTGCGCATGCCCTGGTGGCTGGAATACACGGCCAGTTTC
TTCCCGGTGATCGCCGCGGTGTTCCTGCTGCGTTCGTTCGTGGTGGAGCCGTTCAAGATCCCGTCGGGCTCGATGATCCC
GACGCTGCAGATCGGTGATTTCATCCTCGTCAACAAGTACACCTACGGCGTGCGCCTGCCGATCGTCAACAAGAAGCTCG
TCGAGCTGAATCAGCCGCAACGCGGCGATGTGATGGTCTTCCGCTACCCGAAAGACGAGTCGATGGACTACATCAAGCGC
GTGATCGGGGTGCCGGGCGACGTGGTGAAGTACGACAACAAGCGCCTGACGATCAACGGCCAGCCTGCCATCTACGCGCC
GCAGCAGGACTACATGTACGTGGAAGACACCGGGGACGCGCAACATCCGCGCATCACGTATTCCAAGCAGTACCAGGAAA
CGCTCGGCAGCGTTGCGCACAACATCCTCAACGATAACGACCGCCCGGCCTATGTGTCCGGTCCGGACGATTTTCCGTTC
CGCGAGAACTGCACTTACAATCAGACCGGCTTTACCTGCAAGGTACCTGCAGGTCACTATTTCATGATGGGCGATAATCG
CGACAACAGCGCGGATTCCCGCTACTGGGGCTTCGTGCCGGACAAAAACATCGTCGGGAAAGCGTTCTTCATCTGGATGA
ATCTGGGCGACTGGAAGCGGATCGGCAGCTTCCATTGA

Upstream 100 bases:

>100_bases
GCAGGTGGGCAGCGTTGAAATCCCGCAGGAGGCTTTCCTGGCCATCCTGCGCGTCGAAGAAAAATAACCTGGACGAATCG
CGTAACCGCGTCTCTCATTC

Downstream 100 bases:

>100_bases
TGCTGCCAGGGTTATCGGTCAGTCTCTTTTTTAAACTTCGGCAATTGCACAACGGGGGAAATGCAATGCGGATGCATCGG
GCCGGTCTGGCGGCGCGTCG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNFALILFILVVFTGVAWVADKLMFQRQRQAAATAALAEFDARAQAQVQYGAVADVGAARAQLAEETLRMPWWLEYTASF
FPVIAAVFLLRSFVVEPFKIPSGSMIPTLQIGDFILVNKYTYGVRLPIVNKKLVELNQPQRGDVMVFRYPKDESMDYIKR
VIGVPGDVVKYDNKRLTINGQPAIYAPQQDYMYVEDTGDAQHPRITYSKQYQETLGSVAHNILNDNDRPAYVSGPDDFPF
RENCTYNQTGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDWKRIGSFH

Sequences:

>Translated_305_residues
MNFALILFILVVFTGVAWVADKLMFQRQRQAAATAALAEFDARAQAQVQYGAVADVGAARAQLAEETLRMPWWLEYTASF
FPVIAAVFLLRSFVVEPFKIPSGSMIPTLQIGDFILVNKYTYGVRLPIVNKKLVELNQPQRGDVMVFRYPKDESMDYIKR
VIGVPGDVVKYDNKRLTINGQPAIYAPQQDYMYVEDTGDAQHPRITYSKQYQETLGSVAHNILNDNDRPAYVSGPDDFPF
RENCTYNQTGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDWKRIGSFH
>Mature_305_residues
MNFALILFILVVFTGVAWVADKLMFQRQRQAAATAALAEFDARAQAQVQYGAVADVGAARAQLAEETLRMPWWLEYTASF
FPVIAAVFLLRSFVVEPFKIPSGSMIPTLQIGDFILVNKYTYGVRLPIVNKKLVELNQPQRGDVMVFRYPKDESMDYIKR
VIGVPGDVVKYDNKRLTINGQPAIYAPQQDYMYVEDTGDAQHPRITYSKQYQETLGSVAHNILNDNDRPAYVSGPDDFPF
RENCTYNQTGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDWKRIGSFH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=349, Percent_Identity=40.6876790830946, Blast_Score=222, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 34680; Mature: 34680

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFILVVFTGVAWVADKLMFQRQRQAAATAALAEFDARAQAQVQYGAVADVGAAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
AQLAEETLRMPWWLEYTASFFPVIAAVFLLRSFVVEPFKIPSGSMIPTLQIGDFILVNKY
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCEEEEEEE
TYGVRLPIVNKKLVELNQPQRGDVMVFRYPKDESMDYIKRVIGVPGDVVKYDNKRLTING
ECEEEEECCCCHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPAIYAPQQDYMYVEDTGDAQHPRITYSKQYQETLGSVAHNILNDNDRPAYVSGPDDFPF
CCCEECCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
RENCTYNQTGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDWKR
CCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEEECCCHHH
IGSFH
CCCCC
>Mature Secondary Structure
MNFALILFILVVFTGVAWVADKLMFQRQRQAAATAALAEFDARAQAQVQYGAVADVGAAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
AQLAEETLRMPWWLEYTASFFPVIAAVFLLRSFVVEPFKIPSGSMIPTLQIGDFILVNKY
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCEEEEEEE
TYGVRLPIVNKKLVELNQPQRGDVMVFRYPKDESMDYIKRVIGVPGDVVKYDNKRLTING
ECEEEEECCCCHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPAIYAPQQDYMYVEDTGDAQHPRITYSKQYQETLGSVAHNILNDNDRPAYVSGPDDFPF
CCCEECCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
RENCTYNQTGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDWKR
CCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEEECCCHHH
IGSFH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]