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The map label for this gene is fadA [H]

Identifier: 17545194

GI number: 17545194

Start: 509786

End: 510985

Strand: Direct

Name: fadA [H]

Synonym: RSc0475

Alternate gene names: 17545194

Gene position: 509786-510985 (Clockwise)

Preceding gene: 17545193

Following gene: 17545195

Centisome position: 13.72

GC content: 69.08

Gene sequence:

>1200_bases
ATGACCAAGCAACTGCAAGACGCCTACATCGTCGCCGCCACCCGTTCCCCGATCGGCAAGGCGCCCAAGGGCTCGTTCAA
GAACCTGCGTCCGGACGACCTGCTGGCGACCGTGCTCAAGAGCGCGGTGGCCCAGGTGCCGGACCTGGACCCGAAGCTGA
TCGAAGACGCCATCGTCGGCTGCGCGATCCCCGAAGCGCAGCAGGGCCTGAACGTGGCGCGCATCGGCGCGCTGCTGGCC
GGCCTGCCCAACACCGTGGGCGGCGTGACCGTCAACCGCTTCTGCGCCTCGGGCCTGACCGCCGTGGCCATGGCCGCCGA
CCGCATCCGCGTGGGCGAATCCGACGTGATGATCGCCGCCGGCGTCGAGTCGATGAGCATGGTGCCGATGATGGGCAATT
CGCCGTCGATGTCGCCGGACATCTTCACGCGCGACGAGAACATCGGCATCGCCTACGGCATGGGCCTGACCGCCGAGCGC
GTCGCCCAGCAGTGGAAGATCACGCGCGATGCGCAGGATGCGTTCTCGCTGGCGTCGCACCAGAAGGCATTGGCCGCGCA
GCAGGCCGGCGAGTTCAAGGACGAGATCACCCCGATCGAGATCATCGAGAAGTTCCCCAACCTGGGCACCGGCGCGATCG
ACCTGAAGACGCGCACGCTGTCGCTCGATGAGGGCCCGCGCGCCGACACCTCGCTCGAAGGCCTGGCCAAGCTGCGCGCG
GTGTTCGCCAACAAGGGCAGCGTGACGGCCGGCAACAGCTCGCAGACCTCGGATGGCTCGGGCGCGCTGATCCTGGTGTC
GGAGAAGATCCTCAGGCAGTTCAACCTGACGCCGCTGGCGCGCTTCGTGTCGTTCGCGGTGCGCGGCGTGCCGCCGGAGA
TCATGGGCATCGGCCCGAAGGAAGCGATCCCGGCCGCGCTCAGGGCCGCCGGCCTGACGCAGGACCAGCTCGACTGGATC
GAGCTGAACGAAGCGTTCGCCGCGCAGTCGCTGGCGGTCATCCAGGACCTGGGCCTGGACACCGGCAAGATCAACCCGCT
GGGCGGCGCGATCGCGCTGGGCCACCCGCTGGGCGCGACCGGTGCGATCCGCGCGGCCACGGTCGTGCACGGCCTGCGCC
GCCGCAACCTGAAGTACGGCATGGTGACGATGTGCGTCGGCACCGGCATGGGCGCGGCGGGCATTTTCGAGCGCGTTTGA

Upstream 100 bases:

>100_bases
TCGGCACGGCCAAGACCCAGGAGCGCATCATGGGCATGCTGCAGACCGGTAAGCCGGTGCGCAACTGATCCGCGCGACGA
CAGAGAACAGGAGTTTCATC

Downstream 100 bases:

>100_bases
GCCCGTGCGAGGGGACGGCCCAGGGGCCAACGCGTTCTCCGTCGGCGATCTGTCCGATTCGCCCGTGCCGGTGTGATCCG
GGCGCGGGCATTCTTTCTGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTKQLQDAYIVAATRSPIGKAPKGSFKNLRPDDLLATVLKSAVAQVPDLDPKLIEDAIVGCAIPEAQQGLNVARIGALLA
GLPNTVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPDIFTRDENIGIAYGMGLTAER
VAQQWKITRDAQDAFSLASHQKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDLKTRTLSLDEGPRADTSLEGLAKLRA
VFANKGSVTAGNSSQTSDGSGALILVSEKILRQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALRAAGLTQDQLDWI
ELNEAFAAQSLAVIQDLGLDTGKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERV

Sequences:

>Translated_399_residues
MTKQLQDAYIVAATRSPIGKAPKGSFKNLRPDDLLATVLKSAVAQVPDLDPKLIEDAIVGCAIPEAQQGLNVARIGALLA
GLPNTVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPDIFTRDENIGIAYGMGLTAER
VAQQWKITRDAQDAFSLASHQKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDLKTRTLSLDEGPRADTSLEGLAKLRA
VFANKGSVTAGNSSQTSDGSGALILVSEKILRQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALRAAGLTQDQLDWI
ELNEAFAAQSLAVIQDLGLDTGKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERV
>Mature_398_residues
TKQLQDAYIVAATRSPIGKAPKGSFKNLRPDDLLATVLKSAVAQVPDLDPKLIEDAIVGCAIPEAQQGLNVARIGALLAG
LPNTVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPDIFTRDENIGIAYGMGLTAERV
AQQWKITRDAQDAFSLASHQKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDLKTRTLSLDEGPRADTSLEGLAKLRAV
FANKGSVTAGNSSQTSDGSGALILVSEKILRQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALRAAGLTQDQLDWIE
LNEAFAAQSLAVIQDLGLDTGKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.3877551020408, Blast_Score=298, Evalue=4e-81,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=38.2133995037221, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=36, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=33.743842364532, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4504327, Length=419, Percent_Identity=30.3102625298329, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=31.1224489795918, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1787663, Length=415, Percent_Identity=43.1325301204819, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=41.75, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=40.64039408867, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=38.8613861386139, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1788683, Length=432, Percent_Identity=32.1759259259259, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=39.1521197007481, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=31.4070351758794, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=32.5925925925926, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=442, Percent_Identity=28.5067873303167, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=28.2828282828283, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=43.0348258706468, Blast_Score=291, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6325229, Length=413, Percent_Identity=36.8038740920097, Blast_Score=223, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24655093, Length=408, Percent_Identity=39.2156862745098, Blast_Score=267, Evalue=8e-72,
Organism=Drosophila melanogaster, GI17648125, Length=410, Percent_Identity=38.5365853658537, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24640423, Length=415, Percent_Identity=32.289156626506, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI17137578, Length=441, Percent_Identity=30.3854875283447, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41696; Mature: 41564

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQLQDAYIVAATRSPIGKAPKGSFKNLRPDDLLATVLKSAVAQVPDLDPKLIEDAIVG
CCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAQQGLNVARIGALLAGLPNTVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAA
CCCCHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHEECCCCEEEEE
GVESMSMVPMMGNSPSMSPDIFTRDENIGIAYGMGLTAERVAQQWKITRDAQDAFSLASH
CCCHHEECEECCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
QKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDLKTRTLSLDEGPRADTSLEGLAKLRA
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALILVSEKILRQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALRAAGLTQDQLDWIELNEAFAAQSLAVIQDLGLDTGKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERV
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC
>Mature Secondary Structure 
TKQLQDAYIVAATRSPIGKAPKGSFKNLRPDDLLATVLKSAVAQVPDLDPKLIEDAIVG
CCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAQQGLNVARIGALLAGLPNTVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAA
CCCCHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHEECCCCEEEEE
GVESMSMVPMMGNSPSMSPDIFTRDENIGIAYGMGLTAERVAQQWKITRDAQDAFSLASH
CCCHHEECEECCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
QKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDLKTRTLSLDEGPRADTSLEGLAKLRA
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALILVSEKILRQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALRAAGLTQDQLDWIELNEAFAAQSLAVIQDLGLDTGKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERV
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]