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The map label for this gene is aroQ

Identifier: 17230274

GI number: 17230274

Start: 3379826

End: 3380269

Strand: Direct

Name: aroQ

Synonym: alr2782

Alternate gene names: 17230274

Gene position: 3379826-3380269 (Clockwise)

Preceding gene: 17230273

Following gene: 17230275

Centisome position: 52.7

GC content: 44.82

Gene sequence:

>444_bases
GTGCAACCTCTAAGTATTTTGGTGCTGCACGGGCCAAACCTAAATTTGCTGGGAAAAAGAGAACCAGGAGTTTATGGCTC
CACAACTTTGGCTGAGATTAATAGCTTATTGGCAGAAGCAGCCCTCAAGTTACAGGCAAAAGTGTTTCCCCTACAGTCCA
ATCATGAAGGCGTGTTAGTAGATGCTATTCATGAGGCGTTGGGGAAACATCAGGGAATTTTGATTAATGCAGGAGCTTAT
ACCCATACCAGCGTAGCTTTACGAGATGCGATCGCTGCTGTAAATTTACCCACAGTAGAAGTCCATCTCAGTAATATCTA
TCGCCGAGAAGATTTCCGCCATCATTCCTACATCGCCCCCGTAGTTATTGGTCAAATTAGTGGCTTTGGTGTGCAAAGCT
ATTTATTAGGATTGCAGGGGTTAGTGGCGCATTTGAAGGGATGA

Upstream 100 bases:

>100_bases
AACCGGAGCTAATTCCGATTCCTGTAAACGATCGCCACCGCCGGGGGGGAGCATCGTCGCTCACGTCGTCGCTAAAAGCC
TGAAGGTACGAAACTTGACA

Downstream 100 bases:

>100_bases
AATGGAGAGCAGGGGGTGAGAAAGAATCTATTTATGAAAAAAAGTTAGGTTTAAAACCTCGCTTAAACTCAGCACTTTTC
CTGTTAAAAAAGTTAAAAGT

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type II DHQase

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MQPLSILVLHGPNLNLLGKREPGVYGSTTLAEINSLLAEAALKLQAKVFPLQSNHEGVLVDAIHEALGKHQGILINAGAY
THTSVALRDAIAAVNLPTVEVHLSNIYRREDFRHHSYIAPVVIGQISGFGVQSYLLGLQGLVAHLKG

Sequences:

>Translated_147_residues
MQPLSILVLHGPNLNLLGKREPGVYGSTTLAEINSLLAEAALKLQAKVFPLQSNHEGVLVDAIHEALGKHQGILINAGAY
THTSVALRDAIAAVNLPTVEVHLSNIYRREDFRHHSYIAPVVIGQISGFGVQSYLLGLQGLVAHLKG
>Mature_147_residues
MQPLSILVLHGPNLNLLGKREPGVYGSTTLAEINSLLAEAALKLQAKVFPLQSNHEGVLVDAIHEALGKHQGILINAGAY
THTSVALRDAIAAVNLPTVEVHLSNIYRREDFRHHSYIAPVVIGQISGFGVQSYLLGLQGLVAHLKG

Specific function: Catalyzes a trans-dehydration via an enolate intermediate

COG id: COG0757

COG function: function code E; 3-dehydroquinate dehydratase II

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-II 3-dehydroquinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROQ_NOSS1 (Q8YTE0)

Other databases:

- EMBL:   BA000019
- PIR:   AG2153
- RefSeq:   NP_486822.1
- ProteinModelPortal:   Q8YTE0
- SMR:   Q8YTE0
- STRING:   Q8YTE0
- GeneID:   1106380
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr2782
- NMPDR:   fig|103690.1.peg.3089
- eggNOG:   COG0757
- HOGENOM:   HBG284657
- OMA:   NTHAREG
- ProtClustDB:   PRK05395
- BioCyc:   NSP103690:ALR2782-MONOMER
- HAMAP:   MF_00169
- InterPro:   IPR001874
- InterPro:   IPR018509
- Gene3D:   G3DSA:3.40.50.9100
- PANTHER:   PTHR21272
- PIRSF:   PIRSF001399
- ProDom:   PD004527
- TIGRFAMs:   TIGR01088

Pfam domain/function: PF01220 DHquinase_II; SSF52304 DHquinase_II

EC number: =4.2.1.10

Molecular weight: Translated: 15768; Mature: 15768

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS01029 DEHYDROQUINASE_II

Important sites: ACT_SITE 25-25 ACT_SITE 102-102 BINDING 76-76 BINDING 82-82 BINDING 89-89 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLSILVLHGPNLNLLGKREPGVYGSTTLAEINSLLAEAALKLQAKVFPLQSNHEGVLV
CCCEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHH
DAIHEALGKHQGILINAGAYTHTSVALRDAIAAVNLPTVEVHLSNIYRREDFRHHSYIAP
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEHH
VVIGQISGFGVQSYLLGLQGLVAHLKG
HEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQPLSILVLHGPNLNLLGKREPGVYGSTTLAEINSLLAEAALKLQAKVFPLQSNHEGVLV
CCCEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHH
DAIHEALGKHQGILINAGAYTHTSVALRDAIAAVNLPTVEVHLSNIYRREDFRHHSYIAP
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEHH
VVIGQISGFGVQSYLLGLQGLVAHLKG
HEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840