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The map label for this gene is ilvD

Identifier: 17230263

GI number: 17230263

Start: 3367200

End: 3368891

Strand: Direct

Name: ilvD

Synonym: alr2771

Alternate gene names: 17230263

Gene position: 3367200-3368891 (Clockwise)

Preceding gene: 17230261

Following gene: 17230265

Centisome position: 52.5

GC content: 46.63

Gene sequence:

>1692_bases
ATGTCGGAGAATTTTAGAAGCAAGGCTATCACACAAGGGGTACAGCGATCGCCTAACAGAGCAATGCTGCGGGCTGTTGG
TTTTCAGGATGCAGATTTTACCAAAGCCATTGTAGGTGTTGCCAATGGTTACAGCACGATTACCCCGTGTAATATGGGGA
TAAATCAACTAGCACAAAGGGCAGAAGCTGGTATAAATACTGCTGGAGCAAAGCCGCAAATATTCGGTACAATTACGATT
AGTGATGGGATTTCGATGGGAACCGAAGGGATGAAATATTCCCTGGTATCACGAGAAGTAATCGCTGACTCCATTGAAAC
CGTTTGTAATGGGCAAAGTTTAGACGGGGTAATTGCCATTGGTGGCTGTGATAAGAATATGCCAGGGGCAATGATTGCGA
TCGCCCGGATAAATATCCCTGCTATCTTTGTTTACGGTGGCACAATTAAACCCGGACATTACAACGGTAAAGATTTAACT
GTTGTCAGTTCTTTTGAGGCTGTTGGTGAGTACAGCGCCGGTAAAATTGACGAAAATGAACTGTTAGCAGTAGAACGCAA
TGCTTGTCCTGGTGCAGGTTCCTGCGGTGGGATGTACACAGCAAATACCATGTCCTCTGCTTTTGAAGCACTGGGGATGA
GTTTGCCCTATTCGTCTACAATGGCGGCAGAAGATGACGAAAAAGCTGATAGTACGGAAGAATCAGCCAAGGTATTGGTA
GAGGCGATTCGTCATCAATTATTACCCAGACAGATTATCACTCGTAAGTCCATAGAAAACGCCATATCTGTAATTATGGC
TGTGGGTGGTTCTACTAATGCGGTGTTACATTTTCTAGCGATCGCCCGTGCGGCTGGTGTAGAACTAAATCTGGACGACT
TTGAAACTATTCGTGGTCGTGTCCCCGTTTTGTGCGACTTGAAACCAAGCGGTAGATATGTGGCTACAGACCTGCACAAA
GCTGGTGGTATACCCCAAGTCATGAAAATGTTACTCGTGCATGGTTTACTCCACGGCGACTGTATGACCATCACAGGTAA
AACCATTGCCGAAGTTTTAGCAGATATCCCAGAAGAACCATCGCCTAATCAAGATGTAATTCGTCCTTGGAATAACCCCA
TGTATGCCCAAGGCCACTTGGCTATACTCAAAGGTAATTTGGCAACAGAAGGCGCAGTTGCCAAAATTACTGGTGTGAAA
AATCCTGTGATTACAGGGCCAGCCAAAGTATTTGAATCAGAAGAGGATTGTTTAGATGCAATTTTGGCAGGTAAAATTAA
AGCCGGTGACGTGATTGTCATCCGCTACGAAGGCCCCAAAGGCGGCCCTGGGATGCGAGAAATGTTAGCCCCCACCTCAG
CTATTATCGGTGCAGGTTTAGGCGACTCAGTGGGACTAATTACCGATGGACGCTTCTCCGGTGGTACTTACGGTATGGTT
GTGGGACACGTTGCACCAGAAGCAGCCGTTGGTGGGGCGATCGCTCTGGTACAAGAAGGTGATAGCATCACAATTGATGC
CCACGCCCGTTCTTTGCAGTTGAACATATCAGACGAAGAATTAACCCGTCGTCGTGCCAATTGGCAACCCCGTCCCCCAC
GTTACACTACAGGCATACTGGCAAAATACGCCAAGTTGGTAGCTTCTAGTAGTGTGGGTGCTGTCACCGATTTAGACTTA
TTCAATAAATAG

Upstream 100 bases:

>100_bases
ATTTTCTTTCAAGATGGATGCAAATTAGTACATCATCTGCATGAGAAAATACAGGTAATACAATCGCAACACAAGCGATG
AAGGCACAGAAGGAAAAACG

Downstream 100 bases:

>100_bases
GCGGTAAATTCCAAAAAAGCCTCCTATTTTTAGATTTTGCATTTTGAATTAGTGCAGAATCACCTTTCTTGATTTTAAGT
TTTAATTAGACGTGAGTTCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MSENFRSKAITQGVQRSPNRAMLRAVGFQDADFTKAIVGVANGYSTITPCNMGINQLAQRAEAGINTAGAKPQIFGTITI
SDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVIAIGGCDKNMPGAMIAIARINIPAIFVYGGTIKPGHYNGKDLT
VVSSFEAVGEYSAGKIDENELLAVERNACPGAGSCGGMYTANTMSSAFEALGMSLPYSSTMAAEDDEKADSTEESAKVLV
EAIRHQLLPRQIITRKSIENAISVIMAVGGSTNAVLHFLAIARAAGVELNLDDFETIRGRVPVLCDLKPSGRYVATDLHK
AGGIPQVMKMLLVHGLLHGDCMTITGKTIAEVLADIPEEPSPNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVK
NPVITGPAKVFESEEDCLDAILAGKIKAGDVIVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGMV
VGHVAPEAAVGGAIALVQEGDSITIDAHARSLQLNISDEELTRRRANWQPRPPRYTTGILAKYAKLVASSSVGAVTDLDL
FNK

Sequences:

>Translated_563_residues
MSENFRSKAITQGVQRSPNRAMLRAVGFQDADFTKAIVGVANGYSTITPCNMGINQLAQRAEAGINTAGAKPQIFGTITI
SDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVIAIGGCDKNMPGAMIAIARINIPAIFVYGGTIKPGHYNGKDLT
VVSSFEAVGEYSAGKIDENELLAVERNACPGAGSCGGMYTANTMSSAFEALGMSLPYSSTMAAEDDEKADSTEESAKVLV
EAIRHQLLPRQIITRKSIENAISVIMAVGGSTNAVLHFLAIARAAGVELNLDDFETIRGRVPVLCDLKPSGRYVATDLHK
AGGIPQVMKMLLVHGLLHGDCMTITGKTIAEVLADIPEEPSPNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVK
NPVITGPAKVFESEEDCLDAILAGKIKAGDVIVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGMV
VGHVAPEAAVGGAIALVQEGDSITIDAHARSLQLNISDEELTRRRANWQPRPPRYTTGILAKYAKLVASSSVGAVTDLDL
FNK
>Mature_562_residues
SENFRSKAITQGVQRSPNRAMLRAVGFQDADFTKAIVGVANGYSTITPCNMGINQLAQRAEAGINTAGAKPQIFGTITIS
DGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVIAIGGCDKNMPGAMIAIARINIPAIFVYGGTIKPGHYNGKDLTV
VSSFEAVGEYSAGKIDENELLAVERNACPGAGSCGGMYTANTMSSAFEALGMSLPYSSTMAAEDDEKADSTEESAKVLVE
AIRHQLLPRQIITRKSIENAISVIMAVGGSTNAVLHFLAIARAAGVELNLDDFETIRGRVPVLCDLKPSGRYVATDLHKA
GGIPQVMKMLLVHGLLHGDCMTITGKTIAEVLADIPEEPSPNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVKN
PVITGPAKVFESEEDCLDAILAGKIKAGDVIVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGMVV
GHVAPEAAVGGAIALVQEGDSITIDAHARSLQLNISDEELTRRRANWQPRPPRYTTGILAKYAKLVASSSVGAVTDLDLF
NK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=608, Percent_Identity=38.9802631578947, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1788157, Length=507, Percent_Identity=31.3609467455621, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI2367371, Length=489, Percent_Identity=35.1738241308793, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1786464, Length=517, Percent_Identity=33.2688588007737, Blast_Score=188, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=48.932384341637, Blast_Score=533, Evalue=1e-152,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_NOSS1 (Q8YTE6)

Other databases:

- EMBL:   BA000019
- PIR:   AD2152
- RefSeq:   NP_486811.1
- STRING:   Q8YTE6
- GeneID:   1106369
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr2771
- NMPDR:   fig|103690.1.peg.3078
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- PhylomeDB:   Q8YTE6
- ProtClustDB:   PRK00911
- BioCyc:   NSP103690:ALR2771-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59130; Mature: 58999

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENFRSKAITQGVQRSPNRAMLRAVGFQDADFTKAIVGVANGYSTITPCNMGINQLAQR
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AEAGINTAGAKPQIFGTITISDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVIAI
HHCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGAMIAIARINIPAIFVYGGTIKPGHYNGKDLTVVSSFEAVGEYSAGKIDENE
CCCCCCCCCEEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHCCCCCCCCCCCC
LLAVERNACPGAGSCGGMYTANTMSSAFEALGMSLPYSSTMAAEDDEKADSTEESAKVLV
EEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EAIRHQLLPRQIITRKSIENAISVIMAVGGSTNAVLHFLAIARAAGVELNLDDFETIRGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCHHHHHCCC
VPVLCDLKPSGRYVATDLHKAGGIPQVMKMLLVHGLLHGDCMTITGKTIAEVLADIPEEP
CCEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCC
SPNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVKNPVITGPAKVFESEEDCLDA
CCCCCCCCCCCCCEEECCEEEEEECCCCCCCCEEEEECCCCCCEECHHHHHCCHHHHHHH
ILAGKIKAGDVIVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGMV
HHHCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCEEEEE
VGHVAPEAAVGGAIALVQEGDSITIDAHARSLQLNISDEELTRRRANWQPRPPRYTTGIL
EECCCCCHHCCCEEEEEECCCEEEEEECCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHH
AKYAKLVASSSVGAVTDLDLFNK
HHHHHHHHCCCCCCEECHHHCCC
>Mature Secondary Structure 
SENFRSKAITQGVQRSPNRAMLRAVGFQDADFTKAIVGVANGYSTITPCNMGINQLAQR
CCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AEAGINTAGAKPQIFGTITISDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVIAI
HHCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGAMIAIARINIPAIFVYGGTIKPGHYNGKDLTVVSSFEAVGEYSAGKIDENE
CCCCCCCCCEEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHCCCCCCCCCCCC
LLAVERNACPGAGSCGGMYTANTMSSAFEALGMSLPYSSTMAAEDDEKADSTEESAKVLV
EEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EAIRHQLLPRQIITRKSIENAISVIMAVGGSTNAVLHFLAIARAAGVELNLDDFETIRGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCHHHHHCCC
VPVLCDLKPSGRYVATDLHKAGGIPQVMKMLLVHGLLHGDCMTITGKTIAEVLADIPEEP
CCEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCC
SPNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVKNPVITGPAKVFESEEDCLDA
CCCCCCCCCCCCCEEECCEEEEEECCCCCCCCEEEEECCCCCCEECHHHHHCCHHHHHHH
ILAGKIKAGDVIVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGMV
HHHCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCEEEEE
VGHVAPEAAVGGAIALVQEGDSITIDAHARSLQLNISDEELTRRRANWQPRPPRYTTGIL
EECCCCCHHCCCEEEEEECCCEEEEEECCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHH
AKYAKLVASSSVGAVTDLDLFNK
HHHHHHHHCCCCCCEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840