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The map label for this gene is hhoA [H]

Identifier: 17230250

GI number: 17230250

Start: 3354035

End: 3355258

Strand: Direct

Name: hhoA [H]

Synonym: alr2758

Alternate gene names: 17230250

Gene position: 3354035-3355258 (Clockwise)

Preceding gene: 17230249

Following gene: 17230251

Centisome position: 52.29

GC content: 45.1

Gene sequence:

>1224_bases
GTGAATATGCAATTTTCCAAATTATCCAGGTCTATACGCCAACTCGGTACTCATGTATTAGCAATATTTATAGGAGTTGT
ATTAACGGTTAGCAGTTTGCGTGTTTTGCCGTCGCAAGCGGAACCAGCGCCTAATCCTAGTACAACTGGATCTGCGCCGG
AACTAGTTGCTCAAAGACAATCACCAACTGCGGCTGTTATCGGTAACAGTAGTTTTGTGACAGCAGCTGTGAATCGTGTT
GGTTCAGCAGTGGTGAGGATTGATACAGAACGCACAATTACACGCCGGGTAGATCCATTTTTGGAAGATCCCTTTTTCCG
GCGCTTTTTTGGTGAAGGCTTTCAGGGACAGTTGCCACCAGAACAGATGCGTGGTTTAGGTTCGGGATTTATCATTGATA
AAAGTGGCTTAATCTTAACTAATGCCCATGTGGTAGATAAAGCCGATCGCGTGACTGTTCGCCTGAAAGATGGCCGTAGT
TTTGACGGTAAGGTGCAAGGCATTGATGAAGTCACGGATTTAGCGGTGGTGAAAATCAACGCGGGTAATAGTCTACCAGT
TGCACCCTTGGGTTCTTCTAATAATGTCCAAGTGGGAGACTGGGCGATCGCAGTTGGTAATCCTTTGGGTTTTGATAATA
CTGTTACTTTGGGTATTGTCAGCACCCTCAAGCGTTCTAGCGCTCAAGTGGGGATTACTGATAAGCGTTTAGATTTCATC
CAAACTGATGCAGCCATTAACCCTGGTAACTCTGGTGGCCCGTTGTTAAATGACAAGGGTGAAGTGATTGGGATTAACAC
TGCCATTCGTGCTGATGCAATGGGGATTGGATTTGCGATTCCTATTGATAAAGCTAAAGCGATCGCTACTCAATTGGAAC
GAGATGGTAAAGTTGCTCACCCCTATTTAGGTGTACAAATGGCAACTTTAACACCTGAATTAGCTCAACAAAATAATATT
GACCCCAATTCGGCTTTTGCAATTCCCGAAGTTAACGGTGTTTTGGTGATTCGAGTAGTACCTAACTCCCCGGCTGCTAA
TGCTGGTATCCGACGCGGTGATGTGATTTTGCAAGTTGATGGTCAAGCAATCACCACTGCGGAACAGTTACAAAACGTTG
TGGAAAACAGTCGCCTCGGTCAAGCGTTACAAGTGAGATTGCAACGAGGTAATCAGACACAGCAGTTATCAGTACGCACG
GCTGAATTGCAAAATGCTGCTTAA

Upstream 100 bases:

>100_bases
AAATTTTAAGCAGGAATGTGAGGTTTCCATGTAGTGATTAGTATGCAAATTTGTCAAAATAATTTTAAATTGGGCAAAAT
TTAGACTTCTAGATTAGGTT

Downstream 100 bases:

>100_bases
GGAATAATCAGGTTGATTCATGAGTATAGGGGTGTTTTTTAATACCCCTATATTTTTTATAGGTTAGTGACTGCTATAGG
GCTGCTATTTAATGCTATAT

Product: serine proteinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNMQFSKLSRSIRQLGTHVLAIFIGVVLTVSSLRVLPSQAEPAPNPSTTGSAPELVAQRQSPTAAVIGNSSFVTAAVNRV
GSAVVRIDTERTITRRVDPFLEDPFFRRFFGEGFQGQLPPEQMRGLGSGFIIDKSGLILTNAHVVDKADRVTVRLKDGRS
FDGKVQGIDEVTDLAVVKINAGNSLPVAPLGSSNNVQVGDWAIAVGNPLGFDNTVTLGIVSTLKRSSAQVGITDKRLDFI
QTDAAINPGNSGGPLLNDKGEVIGINTAIRADAMGIGFAIPIDKAKAIATQLERDGKVAHPYLGVQMATLTPELAQQNNI
DPNSAFAIPEVNGVLVIRVVPNSPAANAGIRRGDVILQVDGQAITTAEQLQNVVENSRLGQALQVRLQRGNQTQQLSVRT
AELQNAA

Sequences:

>Translated_407_residues
MNMQFSKLSRSIRQLGTHVLAIFIGVVLTVSSLRVLPSQAEPAPNPSTTGSAPELVAQRQSPTAAVIGNSSFVTAAVNRV
GSAVVRIDTERTITRRVDPFLEDPFFRRFFGEGFQGQLPPEQMRGLGSGFIIDKSGLILTNAHVVDKADRVTVRLKDGRS
FDGKVQGIDEVTDLAVVKINAGNSLPVAPLGSSNNVQVGDWAIAVGNPLGFDNTVTLGIVSTLKRSSAQVGITDKRLDFI
QTDAAINPGNSGGPLLNDKGEVIGINTAIRADAMGIGFAIPIDKAKAIATQLERDGKVAHPYLGVQMATLTPELAQQNNI
DPNSAFAIPEVNGVLVIRVVPNSPAANAGIRRGDVILQVDGQAITTAEQLQNVVENSRLGQALQVRLQRGNQTQQLSVRT
AELQNAA
>Mature_407_residues
MNMQFSKLSRSIRQLGTHVLAIFIGVVLTVSSLRVLPSQAEPAPNPSTTGSAPELVAQRQSPTAAVIGNSSFVTAAVNRV
GSAVVRIDTERTITRRVDPFLEDPFFRRFFGEGFQGQLPPEQMRGLGSGFIIDKSGLILTNAHVVDKADRVTVRLKDGRS
FDGKVQGIDEVTDLAVVKINAGNSLPVAPLGSSNNVQVGDWAIAVGNPLGFDNTVTLGIVSTLKRSSAQVGITDKRLDFI
QTDAAINPGNSGGPLLNDKGEVIGINTAIRADAMGIGFAIPIDKAKAIATQLERDGKVAHPYLGVQMATLTPELAQQNNI
DPNSAFAIPEVNGVLVIRVVPNSPAANAGIRRGDVILQVDGQAITTAEQLQNVVENSRLGQALQVRLQRGNQTQQLSVRT
AELQNAA

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=339, Percent_Identity=37.1681415929204, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI22129776, Length=360, Percent_Identity=36.3888888888889, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI24308541, Length=323, Percent_Identity=35.6037151702786, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI7019477, Length=280, Percent_Identity=41.4285714285714, Blast_Score=178, Evalue=8e-45,
Organism=Escherichia coli, GI1789629, Length=298, Percent_Identity=38.9261744966443, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1789630, Length=407, Percent_Identity=34.1523341523341, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1786356, Length=338, Percent_Identity=38.1656804733728, Blast_Score=185, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=37.1527777777778, Blast_Score=184, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43140; Mature: 43140

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMQFSKLSRSIRQLGTHVLAIFIGVVLTVSSLRVLPSQAEPAPNPSTTGSAPELVAQRQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCC
SPTAAVIGNSSFVTAAVNRVGSAVVRIDTERTITRRVDPFLEDPFFRRFFGEGFQGQLPP
CCCEEEECCCCHHHHHHHHHCCEEEEEECCHHHHHHCCHHHCCHHHHHHHCCCCCCCCCH
EQMRGLGSGFIIDKSGLILTNAHVVDKADRVTVRLKDGRSFDGKVQGIDEVTDLAVVKIN
HHHHCCCCCEEEECCCEEEECCCEECCCCEEEEEEECCCCCCCCCCCCHHCCCEEEEEEE
AGNSLPVAPLGSSNNVQVGDWAIAVGNPLGFDNTVTLGIVSTLKRSSAQVGITDKRLDFI
CCCCCCEEECCCCCCEEECCEEEEECCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHE
QTDAAINPGNSGGPLLNDKGEVIGINTAIRADAMGIGFAIPIDKAKAIATQLERDGKVAH
ECCCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCEEEECCCHHHHHHHHHHCCCCCCC
PYLGVQMATLTPELAQQNNIDPNSAFAIPEVNGVLVIRVVPNSPAANAGIRRGDVILQVD
CCCCEEEECCCHHHHHCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
GQAITTAEQLQNVVENSRLGQALQVRLQRGNQTQQLSVRTAELQNAA
CCEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEHHHCCCC
>Mature Secondary Structure
MNMQFSKLSRSIRQLGTHVLAIFIGVVLTVSSLRVLPSQAEPAPNPSTTGSAPELVAQRQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCC
SPTAAVIGNSSFVTAAVNRVGSAVVRIDTERTITRRVDPFLEDPFFRRFFGEGFQGQLPP
CCCEEEECCCCHHHHHHHHHCCEEEEEECCHHHHHHCCHHHCCHHHHHHHCCCCCCCCCH
EQMRGLGSGFIIDKSGLILTNAHVVDKADRVTVRLKDGRSFDGKVQGIDEVTDLAVVKIN
HHHHCCCCCEEEECCCEEEECCCEECCCCEEEEEEECCCCCCCCCCCCHHCCCEEEEEEE
AGNSLPVAPLGSSNNVQVGDWAIAVGNPLGFDNTVTLGIVSTLKRSSAQVGITDKRLDFI
CCCCCCEEECCCCCCEEECCEEEEECCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHE
QTDAAINPGNSGGPLLNDKGEVIGINTAIRADAMGIGFAIPIDKAKAIATQLERDGKVAH
ECCCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCEEEECCCHHHHHHHHHHCCCCCCC
PYLGVQMATLTPELAQQNNIDPNSAFAIPEVNGVLVIRVVPNSPAANAGIRRGDVILQVD
CCCCEEEECCCHHHHHCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
GQAITTAEQLQNVVENSRLGQALQVRLQRGNQTQQLSVRTAELQNAA
CCEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]