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The map label for this gene is uvrC [H]

Identifier: 17230220

GI number: 17230220

Start: 3323990

End: 3325873

Strand: Direct

Name: uvrC [H]

Synonym: alr2728

Alternate gene names: 17230220

Gene position: 3323990-3325873 (Clockwise)

Preceding gene: 17230218

Following gene: 17230221

Centisome position: 51.83

GC content: 44.69

Gene sequence:

>1884_bases
GTGACAACATCTGCTCAGATACTACCACTGGTGAAAGATCCAGAGCGTTTAGAAGCCCGTCTGTCCGAAATTCCACCGGA
ACCAGGGGTTTATTTCATGCGAGATGGAAGCGATCGCATAATATATATAGGGAAATCACGGAAATTGCGATCGCGGGTTC
GTTCCTATTTCCGCGAAGGGTACAACAAAACAGAACGCATAGCCACGATGGCCAAGTTGGTGACAGAAATTGAATTTATT
GTCACCGATACCGAAGCTGAAGCCTTGGCGTTGGAAGCCAACTTAATCAAGCAGCACCAGCCATACTTTAATGTGCTGCT
GAAGGATGATAAGAAGTATCCCTATGTTTGTATTACTTGGTCAGAAGACTATCCGCGTATTTTCATTACCCGAAAACGAC
AACTAGGTAAAGAAAAAGATAAATATTACGGGCCTTATACGGATTCGGGTTTGTTAAGGGAGATTTTACGTATATCTAAG
CGGATATTTGCCCTCAGACAACGCCCACAACCATTATTTAAAGACCGTCCTTGCTTAAATTATGATTTAGGTCGCTGTCC
TGGTGTGTGTCAACAGCTGATTTCCCCAGAAGAATACCGTAAAACTGTGCAGAAAGTGGCAATGGTGTTCCAAGGACGCA
CTCAGGAATTGATTGATATCTTGAGCGAACAGATGGAGAAAGCGGCGGAGGCGTTGAATTTTGAAGTAGCAGCGCGGATT
CGTGATCAAATTGCTGGGTTAAAATCCCTAACTGCGGAACAGAAAGTTTCCTTACCGGATGATACGGTGTCACGGGATGC
TATTGCTCTAGCAGGTGACGCACAACACGCCTGCATCCAATTATTTCAGATTCGCGCTGGTCAATTGGTGGGACGCTTGG
CTTTTGTGGCTGAATCCCATGCTGAACCAGGTGCTATTTTACAAAGGGTACTAGAAGAACATTACCAAACGGCGGAATCT
GTAGAAATTCCCGCAGAAATTTTAGTCCAGCATGAGTTACCAGATGCTGAGATATTAGCTGATGTTTTAACCCAGCTTAA
GGGAAGAAAAGTAACGATCTTCACGCCCCAGCGCCAAGTTAAGGCAGAATTAATTGAGATGGTAGAGCGTAACGCCCAAT
ATGAATTGCAAAGAATGCAAAAATTAGGCGATCGCAATCATCAAGCAACCCAAGATTTAGCTGCTATTCTCGATTTACCC
AACTTACCCCACCGCATCGAAGGTTACGACATTTCTCACATTCAAGGTTCTAATGCGGTAGCTTCCCAAGTCGTGTTCAT
CGATGGATTACCAGCCAAACAAAATTATCGCCACTACAAAATTAAAAATCCCACTGTTACCATCGGACATTCAGACGATT
TTGCCAGTTTAGCGGAAGTTATCCAAAGAAGATTTCGCAAGTATGCAGAAGATCCACAATTATCACGGGTGGGAAACCCT
GACTGGCCTGATTTGATTATGATTGATGGCGGTAAAGGTCAGTTATCATCGGTAGTTACTGTTTTGCAAGAGATGAACTT
ATTAGAAGACTTGCGGGTTATCAGTTTAGCAAAACGGCGCGAGGAGATTTTCTTACCAGGGGAATCCCAACCCTTAAAAA
CTGATGCTGAACAACCAGGGGTGCAATTGTTACGACGACTGCGGGATGAAGCCCATCGCTTTGCTGTGAGTTTCCATCGT
CAGCAGCGAAGTGATAAATTAAAGCGATCGCGCTTAGATGAAATCCCTGGTTTAGGACACCACCGCCAAAAGCAGATGTT
AGCTCATTTTCGCTCCGTTGACTATATTCGCCAAGCCACACCCTCACAAATAGCCGAAGTTCCAGGGATAGGCCCACATC
TGGCTCAAGCAATTTACGACTATTTCCATCCATCTCACCTCTAG

Upstream 100 bases:

>100_bases
ACTTTATATTTGCTTGATAAAAACCTGTACACTCAGCACAAAGCAGTAATTGTTCTTAAAATAGATATAGGTAAATTTGT
AAGATTACCTGCTGGAGATT

Downstream 100 bases:

>100_bases
CTTTTAAACGCTATCGAGAAAAGCTACGGGTAATTTATTACTAAAGCAATATTACCCATTACCAACAACTAGAATAGACC
TCTTCACCAATCTCTCTGAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTTSAQILPLVKDPERLEARLSEIPPEPGVYFMRDGSDRIIYIGKSRKLRSRVRSYFREGYNKTERIATMAKLVTEIEFI
VTDTEAEALALEANLIKQHQPYFNVLLKDDKKYPYVCITWSEDYPRIFITRKRQLGKEKDKYYGPYTDSGLLREILRISK
RIFALRQRPQPLFKDRPCLNYDLGRCPGVCQQLISPEEYRKTVQKVAMVFQGRTQELIDILSEQMEKAAEALNFEVAARI
RDQIAGLKSLTAEQKVSLPDDTVSRDAIALAGDAQHACIQLFQIRAGQLVGRLAFVAESHAEPGAILQRVLEEHYQTAES
VEIPAEILVQHELPDAEILADVLTQLKGRKVTIFTPQRQVKAELIEMVERNAQYELQRMQKLGDRNHQATQDLAAILDLP
NLPHRIEGYDISHIQGSNAVASQVVFIDGLPAKQNYRHYKIKNPTVTIGHSDDFASLAEVIQRRFRKYAEDPQLSRVGNP
DWPDLIMIDGGKGQLSSVVTVLQEMNLLEDLRVISLAKRREEIFLPGESQPLKTDAEQPGVQLLRRLRDEAHRFAVSFHR
QQRSDKLKRSRLDEIPGLGHHRQKQMLAHFRSVDYIRQATPSQIAEVPGIGPHLAQAIYDYFHPSHL

Sequences:

>Translated_627_residues
MTTSAQILPLVKDPERLEARLSEIPPEPGVYFMRDGSDRIIYIGKSRKLRSRVRSYFREGYNKTERIATMAKLVTEIEFI
VTDTEAEALALEANLIKQHQPYFNVLLKDDKKYPYVCITWSEDYPRIFITRKRQLGKEKDKYYGPYTDSGLLREILRISK
RIFALRQRPQPLFKDRPCLNYDLGRCPGVCQQLISPEEYRKTVQKVAMVFQGRTQELIDILSEQMEKAAEALNFEVAARI
RDQIAGLKSLTAEQKVSLPDDTVSRDAIALAGDAQHACIQLFQIRAGQLVGRLAFVAESHAEPGAILQRVLEEHYQTAES
VEIPAEILVQHELPDAEILADVLTQLKGRKVTIFTPQRQVKAELIEMVERNAQYELQRMQKLGDRNHQATQDLAAILDLP
NLPHRIEGYDISHIQGSNAVASQVVFIDGLPAKQNYRHYKIKNPTVTIGHSDDFASLAEVIQRRFRKYAEDPQLSRVGNP
DWPDLIMIDGGKGQLSSVVTVLQEMNLLEDLRVISLAKRREEIFLPGESQPLKTDAEQPGVQLLRRLRDEAHRFAVSFHR
QQRSDKLKRSRLDEIPGLGHHRQKQMLAHFRSVDYIRQATPSQIAEVPGIGPHLAQAIYDYFHPSHL
>Mature_626_residues
TTSAQILPLVKDPERLEARLSEIPPEPGVYFMRDGSDRIIYIGKSRKLRSRVRSYFREGYNKTERIATMAKLVTEIEFIV
TDTEAEALALEANLIKQHQPYFNVLLKDDKKYPYVCITWSEDYPRIFITRKRQLGKEKDKYYGPYTDSGLLREILRISKR
IFALRQRPQPLFKDRPCLNYDLGRCPGVCQQLISPEEYRKTVQKVAMVFQGRTQELIDILSEQMEKAAEALNFEVAARIR
DQIAGLKSLTAEQKVSLPDDTVSRDAIALAGDAQHACIQLFQIRAGQLVGRLAFVAESHAEPGAILQRVLEEHYQTAESV
EIPAEILVQHELPDAEILADVLTQLKGRKVTIFTPQRQVKAELIEMVERNAQYELQRMQKLGDRNHQATQDLAAILDLPN
LPHRIEGYDISHIQGSNAVASQVVFIDGLPAKQNYRHYKIKNPTVTIGHSDDFASLAEVIQRRFRKYAEDPQLSRVGNPD
WPDLIMIDGGKGQLSSVVTVLQEMNLLEDLRVISLAKRREEIFLPGESQPLKTDAEQPGVQLLRRLRDEAHRFAVSFHRQ
QRSDKLKRSRLDEIPGLGHHRQKQMLAHFRSVDYIRQATPSQIAEVPGIGPHLAQAIYDYFHPSHL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=617, Percent_Identity=34.3598055105348, Blast_Score=352, Evalue=5e-98,
Organism=Escherichia coli, GI1788037, Length=211, Percent_Identity=30.8056872037915, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 71698; Mature: 71567

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSAQILPLVKDPERLEARLSEIPPEPGVYFMRDGSDRIIYIGKSRKLRSRVRSYFREG
CCCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHC
YNKTERIATMAKLVTEIEFIVTDTEAEALALEANLIKQHQPYFNVLLKDDKKYPYVCITW
CCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCHHHHEEECCCCCCEEEEEE
SEDYPRIFITRKRQLGKEKDKYYGPYTDSGLLREILRISKRIFALRQRPQPLFKDRPCLN
CCCCCEEEEEECHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
YDLGRCPGVCQQLISPEEYRKTVQKVAMVFQGRTQELIDILSEQMEKAAEALNFEVAARI
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDQIAGLKSLTAEQKVSLPDDTVSRDAIALAGDAQHACIQLFQIRAGQLVGRLAFVAESH
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
AEPGAILQRVLEEHYQTAESVEIPAEILVQHELPDAEILADVLTQLKGRKVTIFTPQRQV
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHH
KAELIEMVERNAQYELQRMQKLGDRNHQATQDLAAILDLPNLPHRIEGYDISHIQGSNAV
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
ASQVVFIDGLPAKQNYRHYKIKNPTVTIGHSDDFASLAEVIQRRFRKYAEDPQLSRVGNP
HHEEEEEECCCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
DWPDLIMIDGGKGQLSSVVTVLQEMNLLEDLRVISLAKRREEIFLPGESQPLKTDAEQPG
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHH
VQLLRRLRDEAHRFAVSFHRQQRSDKLKRSRLDEIPGLGHHRQKQMLAHFRSVDYIRQAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
PSQIAEVPGIGPHLAQAIYDYFHPSHL
HHHHHHCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTSAQILPLVKDPERLEARLSEIPPEPGVYFMRDGSDRIIYIGKSRKLRSRVRSYFREG
CCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHC
YNKTERIATMAKLVTEIEFIVTDTEAEALALEANLIKQHQPYFNVLLKDDKKYPYVCITW
CCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCHHHHEEECCCCCCEEEEEE
SEDYPRIFITRKRQLGKEKDKYYGPYTDSGLLREILRISKRIFALRQRPQPLFKDRPCLN
CCCCCEEEEEECHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
YDLGRCPGVCQQLISPEEYRKTVQKVAMVFQGRTQELIDILSEQMEKAAEALNFEVAARI
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDQIAGLKSLTAEQKVSLPDDTVSRDAIALAGDAQHACIQLFQIRAGQLVGRLAFVAESH
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
AEPGAILQRVLEEHYQTAESVEIPAEILVQHELPDAEILADVLTQLKGRKVTIFTPQRQV
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHH
KAELIEMVERNAQYELQRMQKLGDRNHQATQDLAAILDLPNLPHRIEGYDISHIQGSNAV
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
ASQVVFIDGLPAKQNYRHYKIKNPTVTIGHSDDFASLAEVIQRRFRKYAEDPQLSRVGNP
HHEEEEEECCCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
DWPDLIMIDGGKGQLSSVVTVLQEMNLLEDLRVISLAKRREEIFLPGESQPLKTDAEQPG
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHH
VQLLRRLRDEAHRFAVSFHRQQRSDKLKRSRLDEIPGLGHHRQKQMLAHFRSVDYIRQAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
PSQIAEVPGIGPHLAQAIYDYFHPSHL
HHHHHHCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA