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The map label for this gene is csd [H]

Identifier: 17229987

GI number: 17229987

Start: 2995394

End: 2996656

Strand: Direct

Name: csd [H]

Synonym: alr2495

Alternate gene names: 17229987

Gene position: 2995394-2996656 (Clockwise)

Preceding gene: 17229986

Following gene: 17229988

Centisome position: 46.7

GC content: 44.73

Gene sequence:

>1263_bases
ATGACTTATACACCTACCAAAACCCTTGCAGATAAAGTCCGCGCCGACTTCCCCATATTGCATCAGGAAGTCAACGGTAA
AACTTTAGTTTACCTAGATAACGCGGCGACATCGCAAAAACCCTTGTTCGTCTTAAATGCACTCAGGGATTATTACGAGC
AATATAACTCCAACGTCCACCGGGGAGCGCATACCCTCAGCGCCAAAGCCACCGACGCTTACGAAGGCGCACGGGATAAA
GTTGCTAAATTTATTAATGCAGCCTCCCGTAAAGAAATTGTTTACACCCGCAACGCCAGCGAAGCGATTAACCTCGTAGC
CTATAGCTGGGGAATGAACAATTTACAAGCTGGTGATGAAATTATTCTGTCGGTGATGGAACACCACAGTAATATAGTTC
CCTGGCAATTTGTAGCTCAAAAAACGGGTGCAGTTCTCAAGTTCGTGGAACTAACACCAGAACAAACCTTGGATATGGAA
CAGTTTAAACAACTGATTTGTGAAAAAACAAAACTGGTTTCCATCGTCCATGTTTCTAACACATTGGGTTGTATAAATCC
AGTGGCAGAGATTGCGGAAATTACTCACAGATACGGCGCGAAATTCTTAGTTGATGCTTGTCAAAGTGTTCCCCATATAC
CAGTTGATGTCCAGCAAATAGACTGTGACTGGTTGGTAGCATCTGGGCATAAAATGTGCGCTCCCACAGGCATCGGATTC
TTATATGGTAAGTTGGCATTATTAGAAGCCATGCCCCCATTTTTTGGTGGTGGTGAGATGATTGCTGAGGTATATTTAGA
CCATTCTACTTATGCCGAATTACCCCATAAATTTGAAGCGGGTACACCTGCAATTGGGGAAGCGATCGCACTCGGTGCAG
CGATAGATTATCTTACTAATATCGGTATGGAGCAAATCCACGCCTATGAAGCCGAATTAACAGCTTATTTGTACCAACAA
TTAGAGCAAATTCCCCAAATTACCCTCTACGGCCCCAAACCCGATGCTAATGGAGAAGGTAGAGCCGCTTTAGCGACATT
TACCACCACAGGAGTCCACGCTAACGACTTATCTACATTATTAGATCAAGAAGGTGTAGCCATCCGTTCTGGACACCACT
GTACCCAACCATTACACCGCCACTTGGGTTTAGCCGCAACCGCACGCGCCAGCTTATCTTTCTACAACACCCGCGAGGAC
ATTGATGTATTCATCAAAGCACTCAAGGAAACCATTGACTTTTTTGCTGGTATCTTTGGTTAA

Upstream 100 bases:

>100_bases
CGTACCTTCCTTGCGAGACAAATTACTAAACACTGTCACTAGTTTTAAATCTCTAACTAATGACTAATGACTATGAGTAT
TGACTATTGACTAATTCCCC

Downstream 100 bases:

>100_bases
TTGAGGGTGGGCAATGCCCACCTTTTGATTTTTATGAAAAAATCAACTTTAACTTTGCTATGCTTGCTTTGGGTTTTGAT
TCCTCATGTGGCGATCGCAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTYTPTKTLADKVRADFPILHQEVNGKTLVYLDNAATSQKPLFVLNALRDYYEQYNSNVHRGAHTLSAKATDAYEGARDK
VAKFINAASRKEIVYTRNASEAINLVAYSWGMNNLQAGDEIILSVMEHHSNIVPWQFVAQKTGAVLKFVELTPEQTLDME
QFKQLICEKTKLVSIVHVSNTLGCINPVAEIAEITHRYGAKFLVDACQSVPHIPVDVQQIDCDWLVASGHKMCAPTGIGF
LYGKLALLEAMPPFFGGGEMIAEVYLDHSTYAELPHKFEAGTPAIGEAIALGAAIDYLTNIGMEQIHAYEAELTAYLYQQ
LEQIPQITLYGPKPDANGEGRAALATFTTTGVHANDLSTLLDQEGVAIRSGHHCTQPLHRHLGLAATARASLSFYNTRED
IDVFIKALKETIDFFAGIFG

Sequences:

>Translated_420_residues
MTYTPTKTLADKVRADFPILHQEVNGKTLVYLDNAATSQKPLFVLNALRDYYEQYNSNVHRGAHTLSAKATDAYEGARDK
VAKFINAASRKEIVYTRNASEAINLVAYSWGMNNLQAGDEIILSVMEHHSNIVPWQFVAQKTGAVLKFVELTPEQTLDME
QFKQLICEKTKLVSIVHVSNTLGCINPVAEIAEITHRYGAKFLVDACQSVPHIPVDVQQIDCDWLVASGHKMCAPTGIGF
LYGKLALLEAMPPFFGGGEMIAEVYLDHSTYAELPHKFEAGTPAIGEAIALGAAIDYLTNIGMEQIHAYEAELTAYLYQQ
LEQIPQITLYGPKPDANGEGRAALATFTTTGVHANDLSTLLDQEGVAIRSGHHCTQPLHRHLGLAATARASLSFYNTRED
IDVFIKALKETIDFFAGIFG
>Mature_419_residues
TYTPTKTLADKVRADFPILHQEVNGKTLVYLDNAATSQKPLFVLNALRDYYEQYNSNVHRGAHTLSAKATDAYEGARDKV
AKFINAASRKEIVYTRNASEAINLVAYSWGMNNLQAGDEIILSVMEHHSNIVPWQFVAQKTGAVLKFVELTPEQTLDMEQ
FKQLICEKTKLVSIVHVSNTLGCINPVAEIAEITHRYGAKFLVDACQSVPHIPVDVQQIDCDWLVASGHKMCAPTGIGFL
YGKLALLEAMPPFFGGGEMIAEVYLDHSTYAELPHKFEAGTPAIGEAIALGAAIDYLTNIGMEQIHAYEAELTAYLYQQL
EQIPQITLYGPKPDANGEGRAALATFTTTGVHANDLSTLLDQEGVAIRSGHHCTQPLHRHLGLAATARASLSFYNTREDI
DVFIKALKETIDFFAGIFG

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=393, Percent_Identity=25.9541984732824, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI156713448, Length=327, Percent_Identity=25.9938837920489, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=49.3765586034913, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1789175, Length=404, Percent_Identity=38.8613861386139, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI48994898, Length=404, Percent_Identity=25.4950495049505, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25143064, Length=351, Percent_Identity=27.0655270655271, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=379, Percent_Identity=22.6912928759894, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=401, Percent_Identity=26.6832917705736, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129463, Length=364, Percent_Identity=26.0989010989011, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46204; Mature: 46073

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTPTKTLADKVRADFPILHQEVNGKTLVYLDNAATSQKPLFVLNALRDYYEQYNSNVH
CCCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHH
RGAHTLSAKATDAYEGARDKVAKFINAASRKEIVYTRNASEAINLVAYSWGMNNLQAGDE
HCCHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEEECCHHHHHEEEEEECCCCCCCCHHH
IILSVMEHHSNIVPWQFVAQKTGAVLKFVELTPEQTLDMEQFKQLICEKTKLVSIVHVSN
HHHHHHHHCCCCCCHHHHHHHHCHHEEEEECCCHHCCCHHHHHHHHHHHHHHEEEEEECC
TLGCINPVAEIAEITHRYGAKFLVDACQSVPHIPVDVQQIDCDWLVASGHKMCAPTGIGF
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCEEECCCEEEECCCCCCCCCCHHH
LYGKLALLEAMPPFFGGGEMIAEVYLDHSTYAELPHKFEAGTPAIGEAIALGAAIDYLTN
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
IGMEQIHAYEAELTAYLYQQLEQIPQITLYGPKPDANGEGRAALATFTTTGVHANDLSTL
CCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHH
LDQEGVAIRSGHHCTQPLHRHLGLAATARASLSFYNTREDIDVFIKALKETIDFFAGIFG
HCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYTPTKTLADKVRADFPILHQEVNGKTLVYLDNAATSQKPLFVLNALRDYYEQYNSNVH
CCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHH
RGAHTLSAKATDAYEGARDKVAKFINAASRKEIVYTRNASEAINLVAYSWGMNNLQAGDE
HCCHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEEECCHHHHHEEEEEECCCCCCCCHHH
IILSVMEHHSNIVPWQFVAQKTGAVLKFVELTPEQTLDMEQFKQLICEKTKLVSIVHVSN
HHHHHHHHCCCCCCHHHHHHHHCHHEEEEECCCHHCCCHHHHHHHHHHHHHHEEEEEECC
TLGCINPVAEIAEITHRYGAKFLVDACQSVPHIPVDVQQIDCDWLVASGHKMCAPTGIGF
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCEEECCCEEEECCCCCCCCCCHHH
LYGKLALLEAMPPFFGGGEMIAEVYLDHSTYAELPHKFEAGTPAIGEAIALGAAIDYLTN
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
IGMEQIHAYEAELTAYLYQQLEQIPQITLYGPKPDANGEGRAALATFTTTGVHANDLSTL
CCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHH
LDQEGVAIRSGHHCTQPLHRHLGLAATARASLSFYNTREDIDVFIKALKETIDFFAGIFG
HCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]