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The map label for this gene is pncB [H]

Identifier: 17229974

GI number: 17229974

Start: 2982519

End: 2983898

Strand: Direct

Name: pncB [H]

Synonym: alr2482

Alternate gene names: 17229974

Gene position: 2982519-2983898 (Clockwise)

Preceding gene: 17229973

Following gene: 17229975

Centisome position: 46.5

GC content: 46.67

Gene sequence:

>1380_bases
ATGACAACTATCCCCATCTGGGATGTTCAGCAAACCCCAGAACTAAACATCTCTGCGGCTGATTACAGCCTACTTACCGA
TCTTTATCAGCTGACAATGGCTGCTTGTTATACAGGTGAAGGTGTAGAACAACGACGGGCTAGCTTTGAGTTATTTGTGC
GGCGATCGCCAGAAGGTTTTGGCTACTTAATTGCGATGGGGTTGGCGCAAGCACTGGAATATTTAGAAAAGTTAAGATTT
AGCCCGGAACAAATAGCCGCATTACAAGCCACAGGAATTTTTGCTCATGCAGGAGAAGGCTTTTGGTCATTGCTAGCCGA
GGGGCGGTTTACTGGGGATGTGTGGGCAGTACCAGAAGGGACAGCCGTATTTGCTAACGAGCCACTGTTACGGGTGGAAG
CACCATTATGGCAAGCACAGTTAGTAGAAACTTACTTATTAAATACACTCAATTACCAAACCTTAGTAGCCACAAGAGCA
GCACGTCTCCGTGATATAGCTGGTGAGCAAGCAACACTTTTGGAATTTGGTACGAGACGAGCCTTTAGCCCCCAAGCGTC
TTTATGGGCAGCACGGGCAGCTTTAGCGGGTGGTTTAGATGCCACCTCCAATGTGTTAGCAGCGCTACAACTGGGACAAC
AGCCAAGTGGTACGATGGCTCACGCCTTGGTTATGGCGTTGTCGGCGATGGAAGGCAGTGAAGAACAAGCCTTTAGTGCG
TTTCATCGCTATTTTCCCGGCGCGCCTTTGTTAATTGATACTTATGATACTATCGCGGCTGCCCAACACTTAGCAGAAAA
AGTGAATACCGGAAAAATGGAATTATCTGGTGTCAGGTTAGATTCTGGTGACTTAGTTAGCTTATCAAAACAAGTGCGAT
CGCTCCTGCCAGATGTATCGATTTTTGCTAGTGGTGACTTAGATGAATGGGAAATTGCCAAACTCCAAGCAGCCGGTGCA
GAAATCGACGGCTACGGACTAGGAACCAAGCTAGTTACAGGTTCCCCCGTGAATGGAGTTTATAAACTCGTAGAAATTGA
TGACATCCCAGTGATGAAAAAGTCCAGTGGTAAAACAACATACCCAGGGCGTAAGCAGATTTTTCGTTCCTTTGGGGATG
GTCAGGTTCAAGCAGACAGATTGGGGTTAATCACAGATACACCCTTAATTACAGAAAAACCTTTGTTGGAATTGGTAGTC
AAAGAAGGTCAACGCCTACAACCACGAGAAACTCTGTCCGCAATTCGCCAACGCACAGCCGCCTCTGTCGCCAGTTTACC
CGAACAAACAAGACGTTTAGATAATCCCGTTCCCGTACCCATACAAATTTCCACCGCATTGCAAGATTTGACAGAAGTTA
CATTGCAACGTCTCAACTAA

Upstream 100 bases:

>100_bases
TGTATTTGCTTGTGAATAAATTATTTCTTCTTAGGGGTTGACAATATTTATGGTAAATTCTACCATAATAAAAAGAGCAT
TCTTTTAAGGAAGCGCTTGC

Downstream 100 bases:

>100_bases
CGACAACTGACAATGAAAAAAATTGCTTTATTTGGTACTAGTGCAGACCCACCAACAGCAGGACATCAGATTATTTTACG
CTGGTTGTCTGAGCGTTATG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTTIPIWDVQQTPELNISAADYSLLTDLYQLTMAACYTGEGVEQRRASFELFVRRSPEGFGYLIAMGLAQALEYLEKLRF
SPEQIAALQATGIFAHAGEGFWSLLAEGRFTGDVWAVPEGTAVFANEPLLRVEAPLWQAQLVETYLLNTLNYQTLVATRA
ARLRDIAGEQATLLEFGTRRAFSPQASLWAARAALAGGLDATSNVLAALQLGQQPSGTMAHALVMALSAMEGSEEQAFSA
FHRYFPGAPLLIDTYDTIAAAQHLAEKVNTGKMELSGVRLDSGDLVSLSKQVRSLLPDVSIFASGDLDEWEIAKLQAAGA
EIDGYGLGTKLVTGSPVNGVYKLVEIDDIPVMKKSSGKTTYPGRKQIFRSFGDGQVQADRLGLITDTPLITEKPLLELVV
KEGQRLQPRETLSAIRQRTAASVASLPEQTRRLDNPVPVPIQISTALQDLTEVTLQRLN

Sequences:

>Translated_459_residues
MTTIPIWDVQQTPELNISAADYSLLTDLYQLTMAACYTGEGVEQRRASFELFVRRSPEGFGYLIAMGLAQALEYLEKLRF
SPEQIAALQATGIFAHAGEGFWSLLAEGRFTGDVWAVPEGTAVFANEPLLRVEAPLWQAQLVETYLLNTLNYQTLVATRA
ARLRDIAGEQATLLEFGTRRAFSPQASLWAARAALAGGLDATSNVLAALQLGQQPSGTMAHALVMALSAMEGSEEQAFSA
FHRYFPGAPLLIDTYDTIAAAQHLAEKVNTGKMELSGVRLDSGDLVSLSKQVRSLLPDVSIFASGDLDEWEIAKLQAAGA
EIDGYGLGTKLVTGSPVNGVYKLVEIDDIPVMKKSSGKTTYPGRKQIFRSFGDGQVQADRLGLITDTPLITEKPLLELVV
KEGQRLQPRETLSAIRQRTAASVASLPEQTRRLDNPVPVPIQISTALQDLTEVTLQRLN
>Mature_458_residues
TTIPIWDVQQTPELNISAADYSLLTDLYQLTMAACYTGEGVEQRRASFELFVRRSPEGFGYLIAMGLAQALEYLEKLRFS
PEQIAALQATGIFAHAGEGFWSLLAEGRFTGDVWAVPEGTAVFANEPLLRVEAPLWQAQLVETYLLNTLNYQTLVATRAA
RLRDIAGEQATLLEFGTRRAFSPQASLWAARAALAGGLDATSNVLAALQLGQQPSGTMAHALVMALSAMEGSEEQAFSAF
HRYFPGAPLLIDTYDTIAAAQHLAEKVNTGKMELSGVRLDSGDLVSLSKQVRSLLPDVSIFASGDLDEWEIAKLQAAGAE
IDGYGLGTKLVTGSPVNGVYKLVEIDDIPVMKKSSGKTTYPGRKQIFRSFGDGQVQADRLGLITDTPLITEKPLLELVVK
EGQRLQPRETLSAIRQRTAASVASLPEQTRRLDNPVPVPIQISTALQDLTEVTLQRLN

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=530, Percent_Identity=33.0188679245283, Blast_Score=192, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71997947, Length=516, Percent_Identity=31.9767441860465, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997952, Length=516, Percent_Identity=31.9767441860465, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997955, Length=209, Percent_Identity=38.755980861244, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24581587, Length=520, Percent_Identity=31.9230769230769, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI161076680, Length=212, Percent_Identity=40.0943396226415, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24581595, Length=212, Percent_Identity=40.0943396226415, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574709, Length=212, Percent_Identity=40.0943396226415, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24581593, Length=212, Percent_Identity=40.0943396226415, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24581591, Length=212, Percent_Identity=40.0943396226415, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 49869; Mature: 49738

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIPIWDVQQTPELNISAADYSLLTDLYQLTMAACYTGEGVEQRRASFELFVRRSPEGF
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEEECCCCC
GYLIAMGLAQALEYLEKLRFSPEQIAALQATGIFAHAGEGFWSLLAEGRFTGDVWAVPEG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCHHHHHHHCCCCCCCEEECCCC
TAVFANEPLLRVEAPLWQAQLVETYLLNTLNYQTLVATRAARLRDIAGEQATLLEFGTRR
CEEECCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
AFSPQASLWAARAALAGGLDATSNVLAALQLGQQPSGTMAHALVMALSAMEGSEEQAFSA
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
FHRYFPGAPLLIDTYDTIAAAQHLAEKVNTGKMELSGVRLDSGDLVSLSKQVRSLLPDVS
HHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCE
IFASGDLDEWEIAKLQAAGAEIDGYGLGTKLVTGSPVNGVYKLVEIDDIPVMKKSSGKTT
EEECCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCEECCCCCCC
YPGRKQIFRSFGDGQVQADRLGLITDTPLITEKPLLELVVKEGQRLQPRETLSAIRQRTA
CCCHHHHHHHCCCCCEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ASVASLPEQTRRLDNPVPVPIQISTALQDLTEVTLQRLN
HHHHHCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTIPIWDVQQTPELNISAADYSLLTDLYQLTMAACYTGEGVEQRRASFELFVRRSPEGF
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEEECCCCC
GYLIAMGLAQALEYLEKLRFSPEQIAALQATGIFAHAGEGFWSLLAEGRFTGDVWAVPEG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCHHHHHHHCCCCCCCEEECCCC
TAVFANEPLLRVEAPLWQAQLVETYLLNTLNYQTLVATRAARLRDIAGEQATLLEFGTRR
CEEECCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
AFSPQASLWAARAALAGGLDATSNVLAALQLGQQPSGTMAHALVMALSAMEGSEEQAFSA
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
FHRYFPGAPLLIDTYDTIAAAQHLAEKVNTGKMELSGVRLDSGDLVSLSKQVRSLLPDVS
HHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCE
IFASGDLDEWEIAKLQAAGAEIDGYGLGTKLVTGSPVNGVYKLVEIDDIPVMKKSSGKTT
EEECCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCEECCCCCCC
YPGRKQIFRSFGDGQVQADRLGLITDTPLITEKPLLELVVKEGQRLQPRETLSAIRQRTA
CCCHHHHHHHCCCCCEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ASVASLPEQTRRLDNPVPVPIQISTALQDLTEVTLQRLN
HHHHHCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]