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The map label for this gene is ahcY

Identifier: 17228909

GI number: 17228909

Start: 1677022

End: 1678299

Strand: Direct

Name: ahcY

Synonym: alr1414

Alternate gene names: 17228909

Gene position: 1677022-1678299 (Clockwise)

Preceding gene: 17228905

Following gene: 17228914

Centisome position: 26.15

GC content: 47.34

Gene sequence:

>1278_bases
ATGACCGCAACTTCTCCCCGATTAAAGCACGAGGTTAAAGACCTCGCCCTCGCTCCCTTGGGAAGACAGCGTATTGAATG
GGCTGGACGGGAAATGCCGGTATTGCGGCAAATCCGCGATCGCTTTGCCCAAGAAAAACCCTTTGCTGGACTTCGCCTTG
TGGCTTGCGCCCACATCACCACAGAAACAGCACATTTGGCGATCGCCTTAAAAGCTGGTGGTGCAGACGCTGTATTGATT
GCTAGTAACCCCTTATCAACTCAAGATGACGTAGCTGCTAGCCTCGTCTTAGACCACGAAATCCCCGTATTTGCTCAAAA
AGGCGAAGATAACGCCACCTACAATCGCCACGTCCAAATAGCTTTAGATCACCGTCCCAATATCATCATTGATGATGGTA
GTGACGTAGTGGCAACTTTGGTACAAGAACGCCAACATCAAATTGCTGATTTGATTGGTACCACTGAAGAAACTACTACC
GGTATTGTCCGTTTACGCGCCATGTTTAAAGATGGCGTTCTCACCTTCCCCGCAGTCAACGTTAACGACGCAGACACCAA
GCATTTCTTTGATAACCGCTACGGTACTGGTCAATCTACCTTAGACGGGATTATCCGCGCTACAAATATTTTGTTAGCTG
GTAAGAACGTCGTCGTTGTCGGTTACGGCTGGTGTGGTAAGGGTACAGCCCTGCGCGCCCGTGGCATGGGTGCAAACGTC
ATCGTTACCGAAATCGACCCCATCAAAGCCATTGAAGCTGTTATGGATGGTTTCCGCGTCCTGCCAATGGCGGAGGCTGC
GCCCCAAGGTGATATCTTTATCACTGTGACTGGTAACAAGCACGTTGTTCGGGGTGAACACTTCGATGTGATGAAAGACG
GTGCGATCGTTTGTAACTCTGGTCACTTTGATTTGGAACTTGATTTAAAATACTTGGCTGCTAACGCCAAAGAAATCAAG
GAAGTCCGTCCTTTCACCGAAGAATATAAATTGACAAACGGTAAATCCGTCGTCGTTCTAGGACAAGGACGTTTGATAAA
CCTAGCTGCGGCTGAAGGACACCCAAGCGCAGTTATGGATATGAGTTTTGCTAACCAAGCTTTAGCTTGTGAATACCTGG
TGAAGAATAAGGGTAAGTTAGCTCCTGGGTTACACTCAATTCCTGTTGAGGTTGATCAAGAAATTGCTCGCTTGAAGTTG
CAAGCAATGGGTATTTACATCGATAGTTTGACTCCTGAGCAAATTGAGTACATTAATTCTTGGACTAGTGGAACTTGA

Upstream 100 bases:

>100_bases
GGTTTTTGGTAATTACCCCCAAAAATTATTAGTCGTGGAATAATTGAATAAAGTGCGTAAAGTATCTACGTAGCTTTTTT
TACTTTTTGAGGAACTTTTG

Downstream 100 bases:

>100_bases
TGTTAGTTAATTAAGTGATTTTTTGGGATAAGCAAAACTGCTTATCCCTTTTTTTATTCCTTTTCTGTTAGAGACCATGT
TCGCAACGCTAACGCGTAGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTATSPRLKHEVKDLALAPLGRQRIEWAGREMPVLRQIRDRFAQEKPFAGLRLVACAHITTETAHLAIALKAGGADAVLI
ASNPLSTQDDVAASLVLDHEIPVFAQKGEDNATYNRHVQIALDHRPNIIIDDGSDVVATLVQERQHQIADLIGTTEETTT
GIVRLRAMFKDGVLTFPAVNVNDADTKHFFDNRYGTGQSTLDGIIRATNILLAGKNVVVVGYGWCGKGTALRARGMGANV
IVTEIDPIKAIEAVMDGFRVLPMAEAAPQGDIFITVTGNKHVVRGEHFDVMKDGAIVCNSGHFDLELDLKYLAANAKEIK
EVRPFTEEYKLTNGKSVVVLGQGRLINLAAAEGHPSAVMDMSFANQALACEYLVKNKGKLAPGLHSIPVEVDQEIARLKL
QAMGIYIDSLTPEQIEYINSWTSGT

Sequences:

>Translated_425_residues
MTATSPRLKHEVKDLALAPLGRQRIEWAGREMPVLRQIRDRFAQEKPFAGLRLVACAHITTETAHLAIALKAGGADAVLI
ASNPLSTQDDVAASLVLDHEIPVFAQKGEDNATYNRHVQIALDHRPNIIIDDGSDVVATLVQERQHQIADLIGTTEETTT
GIVRLRAMFKDGVLTFPAVNVNDADTKHFFDNRYGTGQSTLDGIIRATNILLAGKNVVVVGYGWCGKGTALRARGMGANV
IVTEIDPIKAIEAVMDGFRVLPMAEAAPQGDIFITVTGNKHVVRGEHFDVMKDGAIVCNSGHFDLELDLKYLAANAKEIK
EVRPFTEEYKLTNGKSVVVLGQGRLINLAAAEGHPSAVMDMSFANQALACEYLVKNKGKLAPGLHSIPVEVDQEIARLKL
QAMGIYIDSLTPEQIEYINSWTSGT
>Mature_424_residues
TATSPRLKHEVKDLALAPLGRQRIEWAGREMPVLRQIRDRFAQEKPFAGLRLVACAHITTETAHLAIALKAGGADAVLIA
SNPLSTQDDVAASLVLDHEIPVFAQKGEDNATYNRHVQIALDHRPNIIIDDGSDVVATLVQERQHQIADLIGTTEETTTG
IVRLRAMFKDGVLTFPAVNVNDADTKHFFDNRYGTGQSTLDGIIRATNILLAGKNVVVVGYGWCGKGTALRARGMGANVI
VTEIDPIKAIEAVMDGFRVLPMAEAAPQGDIFITVTGNKHVVRGEHFDVMKDGAIVCNSGHFDLELDLKYLAANAKEIKE
VRPFTEEYKLTNGKSVVVLGQGRLINLAAAEGHPSAVMDMSFANQALACEYLVKNKGKLAPGLHSIPVEVDQEIARLKLQ
AMGIYIDSLTPEQIEYINSWTSGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=423, Percent_Identity=42.3167848699764, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI239937451, Length=396, Percent_Identity=42.6767676767677, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI298286489, Length=430, Percent_Identity=39.7674418604651, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI195539349, Length=430, Percent_Identity=39.7674418604651, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI195539337, Length=430, Percent_Identity=39.7674418604651, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI24308043, Length=430, Percent_Identity=39.7674418604651, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI21361647, Length=428, Percent_Identity=38.3177570093458, Blast_Score=264, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=42.3076923076923, Blast_Score=328, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6320882, Length=435, Percent_Identity=42.2988505747126, Blast_Score=332, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24642172, Length=419, Percent_Identity=42.2434367541766, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24656245, Length=404, Percent_Identity=38.8613861386139, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI45553385, Length=410, Percent_Identity=36.3414634146341, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI45553387, Length=410, Percent_Identity=36.3414634146341, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_NOSS1 (Q8YX05)

Other databases:

- EMBL:   BA000019
- PIR:   AC1983
- RefSeq:   NP_485457.1
- ProteinModelPortal:   Q8YX05
- SMR:   Q8YX05
- STRING:   Q8YX05
- GeneID:   1105009
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr1414
- NMPDR:   fig|103690.1.peg.1724
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   ALHLEAK
- PhylomeDB:   Q8YX05
- ProtClustDB:   PRK05476
- BioCyc:   NSP103690:ALR1414-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 46172; Mature: 46041

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 60-60 BINDING 132-132 BINDING 157-157 BINDING 187-187 BINDING 191-191 BINDING 192-192 BINDING 244-244 BINDING 279-279 BINDING 347-347

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATSPRLKHEVKDLALAPLGRQRIEWAGREMPVLRQIRDRFAQEKPFAGLRLVACAHIT
CCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEE
TETAHLAIALKAGGADAVLIASNPLSTQDDVAASLVLDHEIPVFAQKGEDNATYNRHVQI
ECCEEEEEEEECCCCCEEEEECCCCCCCHHHHEEEEEECCCCEEEECCCCCCCEEEEEEE
ALDHRPNIIIDDGSDVVATLVQERQHQIADLIGTTEETTTGIVRLRAMFKDGVLTFPAVN
EEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECEEC
VNDADTKHFFDNRYGTGQSTLDGIIRATNILLAGKNVVVVGYGWCGKGTALRARGMGANV
CCCCCCHHHHCCCCCCCHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCEEEECCCCCEE
IVTEIDPIKAIEAVMDGFRVLPMAEAAPQGDIFITVTGNKHVVRGEHFDVMKDGAIVCNS
EEECCCHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCEEEECCCCCCEECCCEEEECC
GHFDLELDLKYLAANAKEIKEVRPFTEEYKLTNGKSVVVLGQGRLINLAAAEGHPSAVMD
CCEEEEEEHHHHHCCHHHHHHHCCCHHHHEECCCCEEEEEECCCEEEEEECCCCCCEEEE
MSFANQALACEYLVKNKGKLAPGLHSIPVEVDQEIARLKLQAMGIYIDSLTPEQIEYINS
HHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHC
WTSGT
CCCCC
>Mature Secondary Structure 
TATSPRLKHEVKDLALAPLGRQRIEWAGREMPVLRQIRDRFAQEKPFAGLRLVACAHIT
CCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEE
TETAHLAIALKAGGADAVLIASNPLSTQDDVAASLVLDHEIPVFAQKGEDNATYNRHVQI
ECCEEEEEEEECCCCCEEEEECCCCCCCHHHHEEEEEECCCCEEEECCCCCCCEEEEEEE
ALDHRPNIIIDDGSDVVATLVQERQHQIADLIGTTEETTTGIVRLRAMFKDGVLTFPAVN
EEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECEEC
VNDADTKHFFDNRYGTGQSTLDGIIRATNILLAGKNVVVVGYGWCGKGTALRARGMGANV
CCCCCCHHHHCCCCCCCHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCEEEECCCCCEE
IVTEIDPIKAIEAVMDGFRVLPMAEAAPQGDIFITVTGNKHVVRGEHFDVMKDGAIVCNS
EEECCCHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCEEEECCCCCCEECCCEEEECC
GHFDLELDLKYLAANAKEIKEVRPFTEEYKLTNGKSVVVLGQGRLINLAAAEGHPSAVMD
CCEEEEEEHHHHHCCHHHHHHHCCCHHHHEECCCCEEEEEECCCEEEEEECCCCCCEEEE
MSFANQALACEYLVKNKGKLAPGLHSIPVEVDQEIARLKLQAMGIYIDSLTPEQIEYINS
HHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHC
WTSGT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840