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The map label for this gene is luxQ [H]

Identifier: 17228780

GI number: 17228780

Start: 1527904

End: 1529715

Strand: Direct

Name: luxQ [H]

Synonym: alr1285

Alternate gene names: 17228780

Gene position: 1527904-1529715 (Clockwise)

Preceding gene: 17228778

Following gene: 17228781

Centisome position: 23.82

GC content: 41.11

Gene sequence:

>1812_bases
ATGCAGCAGTATTCAAGCTTACCAGAACACAACTCATCGATAGACACAACGCCAACTCTGTTGGCAGAAAGTCAGCAGCT
TTGCGCTGAGTTATGGCTGGAACGCAGCTTGAACCAGCTACAGACACGCCTGCATAATTGCTTAGAGTCTGCTTTCAACA
CTGTTGCCACAAGAACCACAGAAGCGGATATTTTCCAAACAGTGGTTAATGAACTAGACATTGCTTTAAACAGTAGCAAT
GTAGGTTTCCCTTTGTGTGCTGTGGGTATTGCTCTGTTGCAACCGCAAGCAGCAGTTGGTAAAGTTTACTATATTTCTCG
CCCTCTATCTCTAGGCTGTCAACCTCCACTCTTAGAAGAGAGATGCAAAGACGGGAAAAAACTGCGATTGCAATTGCAAG
AAGCGATCAAAATCACAGATTTACAAAAACTTGAAAATCAACAACCTCCGCGAGCTTGGCAATTAAGGGATGATTTTGAT
GGTGTGATTGGGTGGTTGCTTCTGGCGACAGATAACTTAAAGCCTCACGAAAACACGTTTACCGCACCACATCCTCAACT
TAATACACAACTAATGGAGCGGTCAGCCGAACAATGTGTGAAGGCCTTAGTGCATCTCAAAAAAATACAATCTTTGCAAC
AGAAATCTCAAAATTTAGGTATTTCTAATCAGGAATTGGAGCGGACTAATCAACTGAAAAATCAGTTTTTAGCCAATACA
AGTCACGAAATTCGTACACCTCTAAGCTCGATTATTGGTTTTACTCACCTGCTTCTAGCCCAAGGTTACGATCCAACAAG
AGAACGTCATCATGAATATTTAAATATTATTCAATCTAGCGGTAAACACCTATTGGCTCTGATCAACGATATTTTGGATC
TCTCCAAGATTGAAGCCAATCAGTTAGAAGTACAGTGGGAAAAAGTTAATGTACCAGAACTTTGCCAAAATGTATTAACG
CTGATCAAGGAGAAGGCCGCAAATAAAGGGGTGAAATTATCTTTGGAATTAGATCCCAATATCAAGACCTTTGTTGCTGA
CCCTCTGCGGCTCAAACAGATGCTTTTGAATTTGTTATTTAATGCTCTCAAATTTACCAATCAAGGCACCGTTGGCTTAA
AGGTGACACAGCAAGATTCATTTATCCACTTTACAGTCTGGGACACTGGTAGTGGTATTTCTCCAGAAAATCTGGCGTTA
CTGTTTCAACCATATTTCCAAATTCCTAATTCTTCCGTTGCTCAACATGAAGGTACTGGTTTAGGTTTAGTGGTGACTCG
TAAACTGGCAGAAATTCACAATGGTTCTGTAGAAGTAGAATCCCAAGTTGCTCACGGTTCCCGCTTTACTATTATTTTGC
CTCTACAACAGAATGAGCAAGTATTAGTAGGAGAAGATGTGGAGGATGAAGAAACGAAATCTGCTGCATCTTTGACACCT
AACAGTTCAAAAGAAATTTTGTTAGTTGAGGATGATTTACCCAACGGTGAATTGATGCAAACTCACTTGTCTAAGTTGGG
ATATAACGTTACTTGGGTCAAGAATGCCCATGAAATGTGGGCTAAACTTGACGAACAACAAGCAGCAGTTATCTTAATGG
ATGTCCGGTTACCCGATGGAGATGGTTTAGATTTAGTCAAGCAGTTGCGAGAAAAATCTCAATATCAACAGATTCCTATT
ATTGCCCAAACGGCGATGGCGATGAAAGGCGATCGCGCCGTCTGTCTATCTGCTGGGGTCAACGACTATATTTCTAAACC
CATAGATTTAAATCTCTTGGCCAGTCTGGTGGCTAAGTATAGTCAGCTTTAG

Upstream 100 bases:

>100_bases
AAGTTATGATTTATCGACAAAAAAGAATTGTGAGCTAATATACATAGAATCGTGTTTGCATTTTTTGCAAAACTAAAGTT
GTTCAACGGTCTAGTTGACC

Downstream 100 bases:

>100_bases
GGATTGGGGACGAAAAAGTAAAAAGTGAAAAGGTAAAAGATTTTTCTTTTGACTGTTGGCTTGGACTGGGGATTGGGGGG
AAGAACTAATTACCACTGAC

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MQQYSSLPEHNSSIDTTPTLLAESQQLCAELWLERSLNQLQTRLHNCLESAFNTVATRTTEADIFQTVVNELDIALNSSN
VGFPLCAVGIALLQPQAAVGKVYYISRPLSLGCQPPLLEERCKDGKKLRLQLQEAIKITDLQKLENQQPPRAWQLRDDFD
GVIGWLLLATDNLKPHENTFTAPHPQLNTQLMERSAEQCVKALVHLKKIQSLQQKSQNLGISNQELERTNQLKNQFLANT
SHEIRTPLSSIIGFTHLLLAQGYDPTRERHHEYLNIIQSSGKHLLALINDILDLSKIEANQLEVQWEKVNVPELCQNVLT
LIKEKAANKGVKLSLELDPNIKTFVADPLRLKQMLLNLLFNALKFTNQGTVGLKVTQQDSFIHFTVWDTGSGISPENLAL
LFQPYFQIPNSSVAQHEGTGLGLVVTRKLAEIHNGSVEVESQVAHGSRFTIILPLQQNEQVLVGEDVEDEETKSAASLTP
NSSKEILLVEDDLPNGELMQTHLSKLGYNVTWVKNAHEMWAKLDEQQAAVILMDVRLPDGDGLDLVKQLREKSQYQQIPI
IAQTAMAMKGDRAVCLSAGVNDYISKPIDLNLLASLVAKYSQL

Sequences:

>Translated_603_residues
MQQYSSLPEHNSSIDTTPTLLAESQQLCAELWLERSLNQLQTRLHNCLESAFNTVATRTTEADIFQTVVNELDIALNSSN
VGFPLCAVGIALLQPQAAVGKVYYISRPLSLGCQPPLLEERCKDGKKLRLQLQEAIKITDLQKLENQQPPRAWQLRDDFD
GVIGWLLLATDNLKPHENTFTAPHPQLNTQLMERSAEQCVKALVHLKKIQSLQQKSQNLGISNQELERTNQLKNQFLANT
SHEIRTPLSSIIGFTHLLLAQGYDPTRERHHEYLNIIQSSGKHLLALINDILDLSKIEANQLEVQWEKVNVPELCQNVLT
LIKEKAANKGVKLSLELDPNIKTFVADPLRLKQMLLNLLFNALKFTNQGTVGLKVTQQDSFIHFTVWDTGSGISPENLAL
LFQPYFQIPNSSVAQHEGTGLGLVVTRKLAEIHNGSVEVESQVAHGSRFTIILPLQQNEQVLVGEDVEDEETKSAASLTP
NSSKEILLVEDDLPNGELMQTHLSKLGYNVTWVKNAHEMWAKLDEQQAAVILMDVRLPDGDGLDLVKQLREKSQYQQIPI
IAQTAMAMKGDRAVCLSAGVNDYISKPIDLNLLASLVAKYSQL
>Mature_603_residues
MQQYSSLPEHNSSIDTTPTLLAESQQLCAELWLERSLNQLQTRLHNCLESAFNTVATRTTEADIFQTVVNELDIALNSSN
VGFPLCAVGIALLQPQAAVGKVYYISRPLSLGCQPPLLEERCKDGKKLRLQLQEAIKITDLQKLENQQPPRAWQLRDDFD
GVIGWLLLATDNLKPHENTFTAPHPQLNTQLMERSAEQCVKALVHLKKIQSLQQKSQNLGISNQELERTNQLKNQFLANT
SHEIRTPLSSIIGFTHLLLAQGYDPTRERHHEYLNIIQSSGKHLLALINDILDLSKIEANQLEVQWEKVNVPELCQNVLT
LIKEKAANKGVKLSLELDPNIKTFVADPLRLKQMLLNLLFNALKFTNQGTVGLKVTQQDSFIHFTVWDTGSGISPENLAL
LFQPYFQIPNSSVAQHEGTGLGLVVTRKLAEIHNGSVEVESQVAHGSRFTIILPLQQNEQVLVGEDVEDEETKSAASLTP
NSSKEILLVEDDLPNGELMQTHLSKLGYNVTWVKNAHEMWAKLDEQQAAVILMDVRLPDGDGLDLVKQLREKSQYQQIPI
IAQTAMAMKGDRAVCLSAGVNDYISKPIDLNLLASLVAKYSQL

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=377, Percent_Identity=34.7480106100796, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI48994928, Length=379, Percent_Identity=31.6622691292876, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI1789149, Length=329, Percent_Identity=32.5227963525836, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081816, Length=383, Percent_Identity=31.5926892950392, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=33.976833976834, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=30.3418803418803, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=31.2236286919831, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788549, Length=279, Percent_Identity=27.9569892473118, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=29.6610169491525, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=28.6343612334802, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=29.8701298701299, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=26.9565217391304, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790861, Length=227, Percent_Identity=29.0748898678414, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790300, Length=250, Percent_Identity=26, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789809, Length=115, Percent_Identity=37.3913043478261, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=281, Percent_Identity=25.9786476868327, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1789402, Length=105, Percent_Identity=34.2857142857143, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=26.4840182648402, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787229, Length=112, Percent_Identity=33.0357142857143, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=232, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786599, Length=106, Percent_Identity=32.0754716981132, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=26.5486725663717, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=80, Percent_Identity=41.25, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67372; Mature: 67372

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQYSSLPEHNSSIDTTPTLLAESQQLCAELWLERSLNQLQTRLHNCLESAFNTVATRTT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EADIFQTVVNELDIALNSSNVGFPLCAVGIALLQPQAAVGKVYYISRPLSLGCQPPLLEE
HHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCHHHCEEEEEECCCCCCCCCCHHHH
RCKDGKKLRLQLQEAIKITDLQKLENQQPPRAWQLRDDFDGVIGWLLLATDNLKPHENTF
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TAPHPQLNTQLMERSAEQCVKALVHLKKIQSLQQKSQNLGISNQELERTNQLKNQFLANT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
SHEIRTPLSSIIGFTHLLLAQGYDPTRERHHEYLNIIQSSGKHLLALINDILDLSKIEAN
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
QLEVQWEKVNVPELCQNVLTLIKEKAANKGVKLSLELDPNIKTFVADPLRLKQMLLNLLF
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCHHHHHHHHHHHHH
NALKFTNQGTVGLKVTQQDSFIHFTVWDTGSGISPENLALLFQPYFQIPNSSVAQHEGTG
HHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHEEEEEHHHCCCCCCCHHCCCCC
LGLVVTRKLAEIHNGSVEVESQVAHGSRFTIILPLQQNEQVLVGEDVEDEETKSAASLTP
EEHHHHHHHHHHCCCCEEEEHHHCCCCEEEEEEECCCCCEEEECCCCCCHHHCCHHCCCC
NSSKEILLVEDDLPNGELMQTHLSKLGYNVTWVKNAHEMWAKLDEQQAAVILMDVRLPDG
CCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCEEEEEEEECCCC
DGLDLVKQLREKSQYQQIPIIAQTAMAMKGDRAVCLSAGVNDYISKPIDLNLLASLVAKY
CCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHHHHHHHH
SQL
HCC
>Mature Secondary Structure
MQQYSSLPEHNSSIDTTPTLLAESQQLCAELWLERSLNQLQTRLHNCLESAFNTVATRTT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EADIFQTVVNELDIALNSSNVGFPLCAVGIALLQPQAAVGKVYYISRPLSLGCQPPLLEE
HHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCHHHCEEEEEECCCCCCCCCCHHHH
RCKDGKKLRLQLQEAIKITDLQKLENQQPPRAWQLRDDFDGVIGWLLLATDNLKPHENTF
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TAPHPQLNTQLMERSAEQCVKALVHLKKIQSLQQKSQNLGISNQELERTNQLKNQFLANT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
SHEIRTPLSSIIGFTHLLLAQGYDPTRERHHEYLNIIQSSGKHLLALINDILDLSKIEAN
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
QLEVQWEKVNVPELCQNVLTLIKEKAANKGVKLSLELDPNIKTFVADPLRLKQMLLNLLF
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCHHHHHHHHHHHHH
NALKFTNQGTVGLKVTQQDSFIHFTVWDTGSGISPENLALLFQPYFQIPNSSVAQHEGTG
HHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHEEEEEHHHCCCCCCCHHCCCCC
LGLVVTRKLAEIHNGSVEVESQVAHGSRFTIILPLQQNEQVLVGEDVEDEETKSAASLTP
EEHHHHHHHHHHCCCCEEEEHHHCCCCEEEEEEECCCCCEEEECCCCCCHHHCCHHCCCC
NSSKEILLVEDDLPNGELMQTHLSKLGYNVTWVKNAHEMWAKLDEQQAAVILMDVRLPDG
CCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCEEEEEEEECCCC
DGLDLVKQLREKSQYQQIPIIAQTAMAMKGDRAVCLSAGVNDYISKPIDLNLLASLVAKY
CCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHHHHHHHH
SQL
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]