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The map label for this gene is mscS [H]

Identifier: 17228691

GI number: 17228691

Start: 1408147

End: 1409220

Strand: Direct

Name: mscS [H]

Synonym: alr1196

Alternate gene names: 17228691

Gene position: 1408147-1409220 (Clockwise)

Preceding gene: 17228690

Following gene: 17228692

Centisome position: 21.96

GC content: 33.05

Gene sequence:

>1074_bases
GTGTCTGACACTCAATGGTGTAGTAAAATTTTGCAAGAGTTAATAGCAAAATTAATTATGATTCAATGGCTTTTACCTAT
AGGATTGCCCATATTTGCTTTAATAACGGGACTGATTAGTGAAAAATTTATAATTAATAAGTTTAAAAACTTCGTTTATA
AAAAAGAAATACCCGGAAGCCATATAATTTTTAAGTCTCTGCAAGGTATGCTCCTAACTTGGTTCATACTAGCAGGCATT
TTAGGCGCAGTTATCGCTGCTCCTTTGAAGCCAGACTTTACTAATTTACTGCAAAAAATTATTACAATATTTTTCCTGTC
TTCACTGACATTAGTTTTAGCTAGGTTAGTTTCAGGTTTCATCAGACTATATACTTATAGAACAGAAAGAGCTACGGCGT
CTTTAATTTCTAACTTAGCCAAAGCTACTGTTTTAGTTTTGGGTTGCCTAATTTTGTTACAAACATTAGGAATTGAAATT
ACACCAATTATTACAACTTTAGGAGTCGGTGGTTTAGCCGTTGGTTTAGCGTTACAAGATACACTAGCAAATTTATTCTC
TGGCTTTCATTTAATTATTTCTAAGCAAGTTAGAACTGGAGATTATGTCAAATTAGATGCTGGACAAGAAGGTTACGTCA
CCGATATTTCTTGGCGTAATACCACAATTAAAGAGTTTTCCAATAATGTAATTATCGTTCCTAATTCTAAACTAGCCTCG
GCAATCTTTACTAACTATCATCTACCAGCTAAAGAAATCACATTAACAATGAATGTCGGTGTTAGTTACGATAGTTATTT
AGATCAAGTTGAAAGAGTGACGGTAGAAGTTGCCAAAGAAGTTATGCAGGAGATTGCCCCAGAATTAAAAGAACATGAGC
CATATATAAGGTTCCATACTTTTGGGGATTTTAGTATAGATTTTACATTATATATGCGTGTCAACGAATACTTTGACCAG
CGTATTGGCAAACATCTATTTATTAAAAAACTACACAAACGCTATCAAGAAAATGGTATTTCGATTCCTTTTCCTGTGAG
AAATGTGTATATTCAAGATCCTAATAACAATTAG

Upstream 100 bases:

>100_bases
CTATTTCTCATTTATGAAGTGACTACTTCCGCTACTAGCTATAATTTCATTTTGATTTATCTATTTGCCACAAACATTTT
TTGAATTGGTATAATAAAAA

Downstream 100 bases:

>100_bases
AGAAGAGAAGCAAATAGTTCATATTTCGTTTTTTGTGCATACTTCTGCTATTGTCATCGCTGATTAGTCAGGGTTGCATA
ACTGGCACACGAAGCCAGTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSDTQWCSKILQELIAKLIMIQWLLPIGLPIFALITGLISEKFIINKFKNFVYKKEIPGSHIIFKSLQGMLLTWFILAGI
LGAVIAAPLKPDFTNLLQKIITIFFLSSLTLVLARLVSGFIRLYTYRTERATASLISNLAKATVLVLGCLILLQTLGIEI
TPIITTLGVGGLAVGLALQDTLANLFSGFHLIISKQVRTGDYVKLDAGQEGYVTDISWRNTTIKEFSNNVIIVPNSKLAS
AIFTNYHLPAKEITLTMNVGVSYDSYLDQVERVTVEVAKEVMQEIAPELKEHEPYIRFHTFGDFSIDFTLYMRVNEYFDQ
RIGKHLFIKKLHKRYQENGISIPFPVRNVYIQDPNNN

Sequences:

>Translated_357_residues
MSDTQWCSKILQELIAKLIMIQWLLPIGLPIFALITGLISEKFIINKFKNFVYKKEIPGSHIIFKSLQGMLLTWFILAGI
LGAVIAAPLKPDFTNLLQKIITIFFLSSLTLVLARLVSGFIRLYTYRTERATASLISNLAKATVLVLGCLILLQTLGIEI
TPIITTLGVGGLAVGLALQDTLANLFSGFHLIISKQVRTGDYVKLDAGQEGYVTDISWRNTTIKEFSNNVIIVPNSKLAS
AIFTNYHLPAKEITLTMNVGVSYDSYLDQVERVTVEVAKEVMQEIAPELKEHEPYIRFHTFGDFSIDFTLYMRVNEYFDQ
RIGKHLFIKKLHKRYQENGISIPFPVRNVYIQDPNNN
>Mature_356_residues
SDTQWCSKILQELIAKLIMIQWLLPIGLPIFALITGLISEKFIINKFKNFVYKKEIPGSHIIFKSLQGMLLTWFILAGIL
GAVIAAPLKPDFTNLLQKIITIFFLSSLTLVLARLVSGFIRLYTYRTERATASLISNLAKATVLVLGCLILLQTLGIEIT
PIITTLGVGGLAVGLALQDTLANLFSGFHLIISKQVRTGDYVKLDAGQEGYVTDISWRNTTIKEFSNNVIIVPNSKLASA
IFTNYHLPAKEITLTMNVGVSYDSYLDQVERVTVEVAKEVMQEIAPELKEHEPYIRFHTFGDFSIDFTLYMRVNEYFDQR
IGKHLFIKKLHKRYQENGISIPFPVRNVYIQDPNNN

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=248, Percent_Identity=29.4354838709677, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787591, Length=228, Percent_Identity=28.0701754385965, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786670, Length=217, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI2367355, Length=225, Percent_Identity=24, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 40322; Mature: 40191

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTQWCSKILQELIAKLIMIQWLLPIGLPIFALITGLISEKFIINKFKNFVYKKEIPGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HIIFKSLQGMLLTWFILAGILGAVIAAPLKPDFTNLLQKIITIFFLSSLTLVLARLVSGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRLYTYRTERATASLISNLAKATVLVLGCLILLQTLGIEITPIITTLGVGGLAVGLALQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
TLANLFSGFHLIISKQVRTGDYVKLDAGQEGYVTDISWRNTTIKEFSNNVIIVPNSKLAS
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCCHHHHHCCCEEEEECCHHHH
AIFTNYHLPAKEITLTMNVGVSYDSYLDQVERVTVEVAKEVMQEIAPELKEHEPYIRFHT
HHHHCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FGDFSIDFTLYMRVNEYFDQRIGKHLFIKKLHKRYQENGISIPFPVRNVYIQDPNNN
ECCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
SDTQWCSKILQELIAKLIMIQWLLPIGLPIFALITGLISEKFIINKFKNFVYKKEIPGS
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HIIFKSLQGMLLTWFILAGILGAVIAAPLKPDFTNLLQKIITIFFLSSLTLVLARLVSGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRLYTYRTERATASLISNLAKATVLVLGCLILLQTLGIEITPIITTLGVGGLAVGLALQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
TLANLFSGFHLIISKQVRTGDYVKLDAGQEGYVTDISWRNTTIKEFSNNVIIVPNSKLAS
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCCHHHHHCCCEEEEECCHHHH
AIFTNYHLPAKEITLTMNVGVSYDSYLDQVERVTVEVAKEVMQEIAPELKEHEPYIRFHT
HHHHCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FGDFSIDFTLYMRVNEYFDQRIGKHLFIKKLHKRYQENGISIPFPVRNVYIQDPNNN
ECCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]