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The map label for this gene is phoR [H]

Identifier: 17228666

GI number: 17228666

Start: 1374252

End: 1375598

Strand: Direct

Name: phoR [H]

Synonym: alr1171

Alternate gene names: 17228666

Gene position: 1374252-1375598 (Clockwise)

Preceding gene: 17228665

Following gene: 17228669

Centisome position: 21.43

GC content: 37.94

Gene sequence:

>1347_bases
ATGAATCAAAATAAACTGTTTCGGCTTACCCGTGTTCGTTTAGCTCTGTATTACGCTATTGTTATGGGTTTGATTTTAAG
CCTATCTGCTTTTAGCTTTTATAGGTCTGTGTTTCATGCTCATGTGGTAGCTTTAGACAGTGAAATTGAGACTGTAGCGG
GAACACTGCACGACAGTATTGAACTAAAATTACAGTCACCTGGACGTTTAGAACCTTTAGCAAATCAGTTATTTCCAAAT
ACAGGTAACTGTAGACAGGGAACTACTAATTGTATTCAAGGACAGCTGCATCCTCAACGTCATCTTCTGGGTATTGTCAC
TAAGACTAGCTACTATATCCGTTTTTTTGATACTTCAGGGAAATTAATTGCTAACGCTGGTTATTATCCAGAGGGATTAC
CTGATGTTTTTAATCAAAAAACTTGGCAATTCCTCAAAGACAGCAAAGGTAAAGAGTATCATCAAATTAGCCTATCGCTG
CATACTCAAGATTATCAAGACTGGGGATATATGCAGGTAGGGCGAAGTCTAGAAGAGTTTAATCATTATTTGGATAGTGT
AAAACTAATTTTGATATTAGGACTGCCAATAGCAATGGCTATCATTGCTGGTGCTAGTTGGTGGTTATCTGGATTAGCTA
TGCAGCCAATTTATCAATCATATCGACAAATCCAACAGTTTACAGCCGATGCCGCACATGAATTACGAACTCCTTTAGCT
GCAACAGGCGCAACGGTAGAATCAGCACTTTTAATGCCAAAAATAGATGAACCAGAAACACGAGATATATTGCAAACTAT
ACAGCGTCAAAATCAAAGACTAACAACTCTGGTCGTTGACTTATTGATGTTAGCGCGTTTAGATAGACAAGCTCAAAAGT
TACAGCGTGAAGTTTGTTGTTTAAATGATATCGTTAGCGATTTAATTGAAGAGTTTGCAGCGATGGCAAATGCCGCAGGG
GTAAAGCTGATATATTCAATTCGAGTTAAGCAGAATCTGAATATTATGGGGAATTCTGATCAGCTTTATCGATTGCTTTC
CAACTTAATTGTCAATGCAATTCAATACACACCTAAAGGAGGGGAAGTAACAGTTATCTTGGAACGCAATGATAATTATG
CTGTCATTAAAGTTCAAGATACAGGCATTGGTATCCCACAACATGAACTGACTCGAATTTTTGATCGCTTTTATCGAGTA
AGTAGCGATCGCTCTCGTAACACTGGTGGTTCTGGTTTAGGATTAGCCATTGTTCAGGCTATTACTGAAGCACATCAAGG
CAGTATAGATGTGCAGAGTGAATTAGGTAAAGGTAGTACCTTTACTATTAATTTACGAAGAAAATAA

Upstream 100 bases:

>100_bases
GCGGCCCAAATACGCTTGTTACGTCGTAAACTCACAAGTAACGACTGTCCTAATCCAATTGAAACTCTGCACGGTATGGG
GTATCGTCTTAAGTTCTCAG

Downstream 100 bases:

>100_bases
TTGAAGCGCCTAACATACTGCCATATAACTCTGACTTTTCACGAGATATGGAAAACCCCTCTCCATAGCTTGCTTCTCTT
ACGATGGCGTAAGCCTACCC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNQNKLFRLTRVRLALYYAIVMGLILSLSAFSFYRSVFHAHVVALDSEIETVAGTLHDSIELKLQSPGRLEPLANQLFPN
TGNCRQGTTNCIQGQLHPQRHLLGIVTKTSYYIRFFDTSGKLIANAGYYPEGLPDVFNQKTWQFLKDSKGKEYHQISLSL
HTQDYQDWGYMQVGRSLEEFNHYLDSVKLILILGLPIAMAIIAGASWWLSGLAMQPIYQSYRQIQQFTADAAHELRTPLA
ATGATVESALLMPKIDEPETRDILQTIQRQNQRLTTLVVDLLMLARLDRQAQKLQREVCCLNDIVSDLIEEFAAMANAAG
VKLIYSIRVKQNLNIMGNSDQLYRLLSNLIVNAIQYTPKGGEVTVILERNDNYAVIKVQDTGIGIPQHELTRIFDRFYRV
SSDRSRNTGGSGLGLAIVQAITEAHQGSIDVQSELGKGSTFTINLRRK

Sequences:

>Translated_448_residues
MNQNKLFRLTRVRLALYYAIVMGLILSLSAFSFYRSVFHAHVVALDSEIETVAGTLHDSIELKLQSPGRLEPLANQLFPN
TGNCRQGTTNCIQGQLHPQRHLLGIVTKTSYYIRFFDTSGKLIANAGYYPEGLPDVFNQKTWQFLKDSKGKEYHQISLSL
HTQDYQDWGYMQVGRSLEEFNHYLDSVKLILILGLPIAMAIIAGASWWLSGLAMQPIYQSYRQIQQFTADAAHELRTPLA
ATGATVESALLMPKIDEPETRDILQTIQRQNQRLTTLVVDLLMLARLDRQAQKLQREVCCLNDIVSDLIEEFAAMANAAG
VKLIYSIRVKQNLNIMGNSDQLYRLLSNLIVNAIQYTPKGGEVTVILERNDNYAVIKVQDTGIGIPQHELTRIFDRFYRV
SSDRSRNTGGSGLGLAIVQAITEAHQGSIDVQSELGKGSTFTINLRRK
>Mature_448_residues
MNQNKLFRLTRVRLALYYAIVMGLILSLSAFSFYRSVFHAHVVALDSEIETVAGTLHDSIELKLQSPGRLEPLANQLFPN
TGNCRQGTTNCIQGQLHPQRHLLGIVTKTSYYIRFFDTSGKLIANAGYYPEGLPDVFNQKTWQFLKDSKGKEYHQISLSL
HTQDYQDWGYMQVGRSLEEFNHYLDSVKLILILGLPIAMAIIAGASWWLSGLAMQPIYQSYRQIQQFTADAAHELRTPLA
ATGATVESALLMPKIDEPETRDILQTIQRQNQRLTTLVVDLLMLARLDRQAQKLQREVCCLNDIVSDLIEEFAAMANAAG
VKLIYSIRVKQNLNIMGNSDQLYRLLSNLIVNAIQYTPKGGEVTVILERNDNYAVIKVQDTGIGIPQHELTRIFDRFYRV
SSDRSRNTGGSGLGLAIVQAITEAHQGSIDVQSELGKGSTFTINLRRK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=33.7899543378995, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786783, Length=219, Percent_Identity=36.0730593607306, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788393, Length=221, Percent_Identity=32.579185520362, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=30.2127659574468, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=29.8701298701299, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790346, Length=213, Percent_Identity=31.924882629108, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=31.4410480349345, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=28.125, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=30.5676855895196, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790551, Length=208, Percent_Identity=32.2115384615385, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=31.25, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=202, Percent_Identity=34.6534653465347, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=29.4642857142857, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=222, Percent_Identity=25.6756756756757, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=27.3127753303965, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=26.8518518518519, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=212, Percent_Identity=26.4150943396226, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=203, Percent_Identity=27.0935960591133, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50381; Mature: 50381

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNKLFRLTRVRLALYYAIVMGLILSLSAFSFYRSVFHAHVVALDSEIETVAGTLHDSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCE
ELKLQSPGRLEPLANQLFPNTGNCRQGTTNCIQGQLHPQRHLLGIVTKTSYYIRFFDTSG
EEEECCCCCCCHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHHEEEEECEEEEEEEECCC
KLIANAGYYPEGLPDVFNQKTWQFLKDSKGKEYHQISLSLHTQDYQDWGYMQVGRSLEEF
CEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHH
NHYLDSVKLILILGLPIAMAIIAGASWWLSGLAMQPIYQSYRQIQQFTADAAHELRTPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ATGATVESALLMPKIDEPETRDILQTIQRQNQRLTTLVVDLLMLARLDRQAQKLQREVCC
HCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDIVSDLIEEFAAMANAAGVKLIYSIRVKQNLNIMGNSDQLYRLLSNLIVNAIQYTPKG
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEECCCHHHHHHHHHHHHHHHHCCCCC
GEVTVILERNDNYAVIKVQDTGIGIPQHELTRIFDRFYRVSSDRSRNTGGSGLGLAIVQA
CCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ITEAHQGSIDVQSELGKGSTFTINLRRK
HHHHHCCCCEEHHHCCCCCEEEEEEECC
>Mature Secondary Structure
MNQNKLFRLTRVRLALYYAIVMGLILSLSAFSFYRSVFHAHVVALDSEIETVAGTLHDSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCE
ELKLQSPGRLEPLANQLFPNTGNCRQGTTNCIQGQLHPQRHLLGIVTKTSYYIRFFDTSG
EEEECCCCCCCHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHHEEEEECEEEEEEEECCC
KLIANAGYYPEGLPDVFNQKTWQFLKDSKGKEYHQISLSLHTQDYQDWGYMQVGRSLEEF
CEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHH
NHYLDSVKLILILGLPIAMAIIAGASWWLSGLAMQPIYQSYRQIQQFTADAAHELRTPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ATGATVESALLMPKIDEPETRDILQTIQRQNQRLTTLVVDLLMLARLDRQAQKLQREVCC
HCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDIVSDLIEEFAAMANAAGVKLIYSIRVKQNLNIMGNSDQLYRLLSNLIVNAIQYTPKG
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEECCCHHHHHHHHHHHHHHHHCCCCC
GEVTVILERNDNYAVIKVQDTGIGIPQHELTRIFDRFYRVSSDRSRNTGGSGLGLAIVQA
CCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ITEAHQGSIDVQSELGKGSTFTINLRRK
HHHHHCCCCEEHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]