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The map label for this gene is ndhD [H]

Identifier: 17228365

GI number: 17228365

Start: 999925

End: 1001427

Strand: Direct

Name: ndhD [H]

Synonym: alr0870

Alternate gene names: 17228365

Gene position: 999925-1001427 (Clockwise)

Preceding gene: 17228364

Following gene: 17228366

Centisome position: 15.59

GC content: 44.18

Gene sequence:

>1503_bases
ATGCTTAGTGTATTGATCTTTGCCCCATTGTTGGGTGCGCTGCTAATTGGTCTACTCCCATCTGGTATTAATGGGAGAAG
TTCCCGTAATGTGGCATTGATTTTTGCCAGTGTGACTTTTCTGTGGTCGGTGATACTGGCTAGCCAGTTTCAACCAGGAG
AAGTTAACCAACAGTTTAGTGAGTTTCTACCTTGGATAGATACCTTGGGATTGAGTTATAATCTTGGTGTGGATGGTCTA
TCTTTGCCATTGCTGGTGTTGAATGGATTATTAACTGGCATTGCCATTTACAGCAGCGATGAATCCTTGCAACGTCCCAA
GTTTTATTACTCCTTGATATTGGTGTTGAGTGCTGGGGTATCAGGAGCCTTTCTGGCACAAGATTTACTACTATTCTTCC
TGTTTTACGAGCTGGAACTCATTCCTCTGTATCTCTTAATTGCAATTTGGGGTGGTGCAAGACGAGGCTATGCAGCTACG
AAATTTTTGATCTACACTGCTTTTTCGGGAATTTTGATTTTAGCCAGTTTCTTGGGCTTGGTTTGGTTGAGTGGGTCTGG
TAGTTTTGCACTATCAACCTTAAATGCTCAGTCTCTACCCTTAGCAACTCAACTATTACTTCTAGCAGGGATTTTAGTAG
GTTTTGGCATCAAAATGCCCTTAGTTCCTTTTCACACTTGGTTACCAGATGCACACGTTGAAGCCTCTACACCGATTTCT
GTGTTGCTGGCTGGGGTACTGTTGAAGTTGGGAACTTATGGCTTGTTGCGATTTGGGATGAACTTGTTACCAGCAGCCTG
GAATTATTTAGCACCTTGGTTGGCGGCTTGGGCGGTGGTAAGTGTGTTGTATGGTTCATCATGTGCGATCGCGCAAACAG
ACATGAAAAAAATGGTAGCCTACAGTTCAATAGGACATATGGGCTATGTGCTGTTAGCGGCGGCGGCAGCTACACCTTTA
AGTACCTTGGGCGCTGTCATGCAGATGATTAGCCACGGTTTAATTTCGGCACTGTTGTTTTTGTTGGTGGGGGTTGTGTA
TAAAAAAGCAGGTAGCCGCGATTTAGATGTAATCCGAGGCTTATTGAACCCAGAACGGGGTATGCCTGTAATTGGTACTT
TGATGATTGTTGGCGTGATGGCTAGCGCCGGGACTCCGGGGATGGTGGGATTTATCTCCGAATTTATTATATTTCGGGGT
TCTTTTGCGGTTTTTCCGGTGCAAACCCTGTTGTCGATGATTGGTACTGGGTTAACGGCGGTTTACTTTTTAATTCTCGT
CAATAAAGCATTTTTTGGGCGCTTATCGGCCCAGGTGATGAATTTACCACGGATTTATTGGAGCGATCGCGCTCCTGCCT
TTATCTTAGCGGTGCTAATTGTGATTTTTGGTATCCAACCTTCTTGGTTAGCCCGTTGGACTGAACCTACCATTACAGCT
ATGTTTAGTGTTGAAAGTACGGTGGCAACAGTCTCTTTAAATAAAGTAAAGGAGAAAAGTTAA

Upstream 100 bases:

>100_bases
TTGCCTTTTTAGTCAGTTGTCAATAGAAGAGACGTGCATACAACGTCTGTACATTAATTCTTCCCCCTGCCTAAACTTCC
TCATTTCCCCATGATTATCT

Downstream 100 bases:

>100_bases
TAGTGGGTAATGGGTAATGGGTAATTGAAGTTTATTTACCTTTTACCTATTACTAACCTCCAAGAATAATATACATCTAC
AAACAGAAAAATATTTTTAT

Product: NAD(P)H-quinone oxidoreductase subunit D4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLSVLIFAPLLGALLIGLLPSGINGRSSRNVALIFASVTFLWSVILASQFQPGEVNQQFSEFLPWIDTLGLSYNLGVDGL
SLPLLVLNGLLTGIAIYSSDESLQRPKFYYSLILVLSAGVSGAFLAQDLLLFFLFYELELIPLYLLIAIWGGARRGYAAT
KFLIYTAFSGILILASFLGLVWLSGSGSFALSTLNAQSLPLATQLLLLAGILVGFGIKMPLVPFHTWLPDAHVEASTPIS
VLLAGVLLKLGTYGLLRFGMNLLPAAWNYLAPWLAAWAVVSVLYGSSCAIAQTDMKKMVAYSSIGHMGYVLLAAAAATPL
STLGAVMQMISHGLISALLFLLVGVVYKKAGSRDLDVIRGLLNPERGMPVIGTLMIVGVMASAGTPGMVGFISEFIIFRG
SFAVFPVQTLLSMIGTGLTAVYFLILVNKAFFGRLSAQVMNLPRIYWSDRAPAFILAVLIVIFGIQPSWLARWTEPTITA
MFSVESTVATVSLNKVKEKS

Sequences:

>Translated_500_residues
MLSVLIFAPLLGALLIGLLPSGINGRSSRNVALIFASVTFLWSVILASQFQPGEVNQQFSEFLPWIDTLGLSYNLGVDGL
SLPLLVLNGLLTGIAIYSSDESLQRPKFYYSLILVLSAGVSGAFLAQDLLLFFLFYELELIPLYLLIAIWGGARRGYAAT
KFLIYTAFSGILILASFLGLVWLSGSGSFALSTLNAQSLPLATQLLLLAGILVGFGIKMPLVPFHTWLPDAHVEASTPIS
VLLAGVLLKLGTYGLLRFGMNLLPAAWNYLAPWLAAWAVVSVLYGSSCAIAQTDMKKMVAYSSIGHMGYVLLAAAAATPL
STLGAVMQMISHGLISALLFLLVGVVYKKAGSRDLDVIRGLLNPERGMPVIGTLMIVGVMASAGTPGMVGFISEFIIFRG
SFAVFPVQTLLSMIGTGLTAVYFLILVNKAFFGRLSAQVMNLPRIYWSDRAPAFILAVLIVIFGIQPSWLARWTEPTITA
MFSVESTVATVSLNKVKEKS
>Mature_500_residues
MLSVLIFAPLLGALLIGLLPSGINGRSSRNVALIFASVTFLWSVILASQFQPGEVNQQFSEFLPWIDTLGLSYNLGVDGL
SLPLLVLNGLLTGIAIYSSDESLQRPKFYYSLILVLSAGVSGAFLAQDLLLFFLFYELELIPLYLLIAIWGGARRGYAAT
KFLIYTAFSGILILASFLGLVWLSGSGSFALSTLNAQSLPLATQLLLLAGILVGFGIKMPLVPFHTWLPDAHVEASTPIS
VLLAGVLLKLGTYGLLRFGMNLLPAAWNYLAPWLAAWAVVSVLYGSSCAIAQTDMKKMVAYSSIGHMGYVLLAAAAATPL
STLGAVMQMISHGLISALLFLLVGVVYKKAGSRDLDVIRGLLNPERGMPVIGTLMIVGVMASAGTPGMVGFISEFIIFRG
SFAVFPVQTLLSMIGTGLTAVYFLILVNKAFFGRLSAQVMNLPRIYWSDRAPAFILAVLIVIFGIQPSWLARWTEPTITA
MFSVESTVATVSLNKVKEKS

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=375, Percent_Identity=33.0666666666667, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI251831117, Length=206, Percent_Identity=29.126213592233, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788613, Length=401, Percent_Identity=41.645885286783, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1788827, Length=387, Percent_Identity=29.1989664082687, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788831, Length=210, Percent_Identity=36.6666666666667, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788829, Length=417, Percent_Identity=29.2565947242206, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI145693160, Length=306, Percent_Identity=31.0457516339869, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI2367154, Length=331, Percent_Identity=26.8882175226586, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788614, Length=461, Percent_Identity=27.765726681128, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53709; Mature: 53709

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVLIFAPLLGALLIGLLPSGINGRSSRNVALIFASVTFLWSVILASQFQPGEVNQQFS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
EFLPWIDTLGLSYNLGVDGLSLPLLVLNGLLTGIAIYSSDESLQRPKFYYSLILVLSAGV
HHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHEECCCCHHHCHHHHHHHHHHHHCCC
SGAFLAQDLLLFFLFYELELIPLYLLIAIWGGARRGYAATKFLIYTAFSGILILASFLGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VWLSGSGSFALSTLNAQSLPLATQLLLLAGILVGFGIKMPLVPFHTWLPDAHVEASTPIS
EEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCHH
VLLAGVLLKLGTYGLLRFGMNLLPAAWNYLAPWLAAWAVVSVLYGSSCAIAQTDMKKMVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YSSIGHMGYVLLAAAAATPLSTLGAVMQMISHGLISALLFLLVGVVYKKAGSRDLDVIRG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLNPERGMPVIGTLMIVGVMASAGTPGMVGFISEFIIFRGSFAVFPVQTLLSMIGTGLTA
HCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHH
VYFLILVNKAFFGRLSAQVMNLPRIYWSDRAPAFILAVLIVIFGIQPSWLARWTEPTITA
HHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHCCCHHHHHHCCCCHHHE
MFSVESTVATVSLNKVKEKS
EEEHHHHHHHEEHHHHHCCC
>Mature Secondary Structure
MLSVLIFAPLLGALLIGLLPSGINGRSSRNVALIFASVTFLWSVILASQFQPGEVNQQFS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
EFLPWIDTLGLSYNLGVDGLSLPLLVLNGLLTGIAIYSSDESLQRPKFYYSLILVLSAGV
HHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHEECCCCHHHCHHHHHHHHHHHHCCC
SGAFLAQDLLLFFLFYELELIPLYLLIAIWGGARRGYAATKFLIYTAFSGILILASFLGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VWLSGSGSFALSTLNAQSLPLATQLLLLAGILVGFGIKMPLVPFHTWLPDAHVEASTPIS
EEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCHH
VLLAGVLLKLGTYGLLRFGMNLLPAAWNYLAPWLAAWAVVSVLYGSSCAIAQTDMKKMVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YSSIGHMGYVLLAAAAATPLSTLGAVMQMISHGLISALLFLLVGVVYKKAGSRDLDVIRG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLNPERGMPVIGTLMIVGVMASAGTPGMVGFISEFIIFRGSFAVFPVQTLLSMIGTGLTA
HCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHH
VYFLILVNKAFFGRLSAQVMNLPRIYWSDRAPAFILAVLIVIFGIQPSWLARWTEPTITA
HHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHCCCHHHHHHCCCCHHHE
MFSVESTVATVSLNKVKEKS
EEEHHHHHHHEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]