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The map label for this gene is dsbC

Identifier: 16766344

GI number: 16766344

Start: 3203688

End: 3204401

Strand: Reverse

Name: dsbC

Synonym: STM3043

Alternate gene names: 16766344

Gene position: 3204401-3203688 (Counterclockwise)

Preceding gene: 16766345

Following gene: 16766343

Centisome position: 65.97

GC content: 50.28

Gene sequence:

>714_bases
ATGAAAAAGCGTTTTATGATGTTCACTTTACTGGCGGCGGTGTTTTCAGGCGTGGCCCATGCGGATGATGCGGCTATCCG
TCAGTCGCTGGCTAAGCTGGGCGTTCAGAGTACGGAAATTCAGGCCTCGCCAGTGGCAGGGATGAAAACCGTCCTCACTC
ACAGCGGCGTACTGTACGTCACTGATGACGGCAAACATATTATTCAAGGGCCGATGTATGACGTGAGCGGCGCGCATCCG
GTAAACGTGACGAACAAACTGCTGATGAGCCAGCTAAATGCGCTGGAAAAAGAGATGATCGTCTATAAAGCGCCGGATGA
GAAACATGTCATTACTGTTTTTACCGATATCACCTGCGGCTATTGTCATAAGCTACATGAAGAGATGAAAGATTATAACG
CGCTGGGGATCACGGTACGTTATCTGGCTTTTCCGCGCCAGGGGCTGGAAAGCCAGGCGGAGCAGGATATGAAATCTATC
TGGTGCGCCAAAGACAAAAACAAAGCGTTTGATGACGCCATGGCAGGTAAGGGCGTGAAACCGGCAAGCTGTGACGTGAA
CATTGCTGATCATTATGCGTTGGGCGTGCAGTTGGGCGTTAGCGGTACGCCAGCCATTGTATTGAGTAACGGCTATGTGG
TGCCTGGCTATCAGGGACCGAAAGAGATGAAAGCGTTTCTTGATGAGCATCAAAAACAGACCAGTGGTAAATAA

Upstream 100 bases:

>100_bases
CGACGACACAAATTTATACGCATGTCGCAACGGAGCGTTTGCGTCAACTTCATCAACAGCACCATCCGCGGGCATGAGTG
CTGACAGGAAAGGATAGTTT

Downstream 100 bases:

>100_bases
TACGCGTGAAACAACAGAGACAACTTCGTCGGCGCGAGGCTGATGAGACGGCGGAACTCCCCGCCGATCTTCCTCCATTA
CTACGACGTTTATATGCCAG

Product: thiol:disulfide interchange protein DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKKRFMMFTLLAAVFSGVAHADDAAIRQSLAKLGVQSTEIQASPVAGMKTVLTHSGVLYVTDDGKHIIQGPMYDVSGAHP
VNVTNKLLMSQLNALEKEMIVYKAPDEKHVITVFTDITCGYCHKLHEEMKDYNALGITVRYLAFPRQGLESQAEQDMKSI
WCAKDKNKAFDDAMAGKGVKPASCDVNIADHYALGVQLGVSGTPAIVLSNGYVVPGYQGPKEMKAFLDEHQKQTSGK

Sequences:

>Translated_237_residues
MKKRFMMFTLLAAVFSGVAHADDAAIRQSLAKLGVQSTEIQASPVAGMKTVLTHSGVLYVTDDGKHIIQGPMYDVSGAHP
VNVTNKLLMSQLNALEKEMIVYKAPDEKHVITVFTDITCGYCHKLHEEMKDYNALGITVRYLAFPRQGLESQAEQDMKSI
WCAKDKNKAFDDAMAGKGVKPASCDVNIADHYALGVQLGVSGTPAIVLSNGYVVPGYQGPKEMKAFLDEHQKQTSGK
>Mature_237_residues
MKKRFMMFTLLAAVFSGVAHADDAAIRQSLAKLGVQSTEIQASPVAGMKTVLTHSGVLYVTDDGKHIIQGPMYDVSGAHP
VNVTNKLLMSQLNALEKEMIVYKAPDEKHVITVFTDITCGYCHKLHEEMKDYNALGITVRYLAFPRQGLESQAEQDMKSI
WCAKDKNKAFDDAMAGKGVKPASCDVNIADHYALGVQLGVSGTPAIVLSNGYVVPGYQGPKEMKAFLDEHQKQTSGK

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily

Homologues:

Organism=Escherichia coli, GI1789260, Length=237, Percent_Identity=83.5443037974684, Blast_Score=419, Evalue=1e-119,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): DSBC_SALTY (P55890)

Other databases:

- EMBL:   AE006468
- EMBL:   U92524
- RefSeq:   NP_461959.1
- ProteinModelPortal:   P55890
- SMR:   P55890
- PRIDE:   P55890
- GeneID:   1254566
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM3043
- NMPDR:   fig|99287.1.peg.2936
- HOGENOM:   HBG469935
- OMA:   GLYEVKL
- ProtClustDB:   PRK10877
- BioCyc:   STYP99287:STM3043-MONOMER
- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.10.450.70
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10411 DsbC_N; SSF54423 Disulfide_bond_isomerase_N; SSF52833 Thiordxn-like_fd

EC number: 5.3.4.1

Molecular weight: Translated: 25836; Mature: 25836

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00194 THIOREDOXIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRFMMFTLLAAVFSGVAHADDAAIRQSLAKLGVQSTEIQASPVAGMKTVLTHSGVLYV
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEE
TDDGKHIIQGPMYDVSGAHPVNVTNKLLMSQLNALEKEMIVYKAPDEKHVITVFTDITCG
ECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCHHH
YCHKLHEEMKDYNALGITVRYLAFPRQGLESQAEQDMKSIWCAKDKNKAFDDAMAGKGVK
HHHHHHHHHHCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
PASCDVNIADHYALGVQLGVSGTPAIVLSNGYVVPGYQGPKEMKAFLDEHQKQTSGK
CCCCCCCCCCCEEEEEEECCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKRFMMFTLLAAVFSGVAHADDAAIRQSLAKLGVQSTEIQASPVAGMKTVLTHSGVLYV
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEE
TDDGKHIIQGPMYDVSGAHPVNVTNKLLMSQLNALEKEMIVYKAPDEKHVITVFTDITCG
ECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCHHH
YCHKLHEEMKDYNALGITVRYLAFPRQGLESQAEQDMKSIWCAKDKNKAFDDAMAGKGVK
HHHHHHHHHHCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
PASCDVNIADHYALGVQLGVSGTPAIVLSNGYVVPGYQGPKEMKAFLDEHQKQTSGK
CCCCCCCCCCCEEEEEEECCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609; 9370270