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The map label for this gene is ldcC [H]

Identifier: 16763624

GI number: 16763624

Start: 276022

End: 278163

Strand: Direct

Name: ldcC [H]

Synonym: STM0234

Alternate gene names: 16763624

Gene position: 276022-278163 (Clockwise)

Preceding gene: 16763623

Following gene: 16763625

Centisome position: 5.68

GC content: 51.96

Gene sequence:

>2142_bases
ATGAACATCATCGCCATTATGGGGCCGCACGGGGTTTATTATAAAGATGAACCCATCAAGGAGCTTGAGCGTGCATTACA
ATCCCTGGGATTTCAAATTATCTGGCCGCAAAATAGCGTTGACTTGTTGAAGTTTATTGAACATAACCCGCGCATCTGCG
GCGTTATTTTTGACTGGGATGAATACAGTCTCGACCTTTGTAGCGAAATCAACCAGCTAAATGAATACCTTCCTCTCTAC
GCCTTTATCAATACCAACTCCACGCTGGACGTTAGCGTTCACGATATGCGCATGGCGCTGTGGTTTTTTGAGTATGCATT
GGGGCTGGCTGAAGATATCGCGACGCGCATTCATCAATATACAAACGAATATCTCGATAATATTACGCCGCCGTTTACCA
AAGCGCTTTTTACCTACGCCAAAGAAGGAAAATATACCTTTTGTACGCCGGGTCATATGGCGGGAACGGCGTATCAGAAA
AGCCCGCCAGGCTGCCTGTTTTATGACTTTTTTGGCGGCAATACCTTAAAAGCTGATGTGTCGATTTCGGTGACTGAACT
GGGATCGCTGCTGGATCACACCGGGCCGCATCTGGAAGCGGAAGAGTATATCGCCCGTACTTTTGGCGCCGAGCAGAGCT
ATATGGTGACGAACGGTACGTCGACCTCGAATAAAATTGTCGGTATGTATGCCGCGCCTGCGGGAAGTACGCTACTTATT
GATCGTAATTGTCATAAATCGCTGGCGCATTTGCTGATGATGAGCGATGTGGTGCCTCTCTGGTTGAAGCCGACGCGCAA
TGCGCTCGGCATTCTCGGCGGTATTCCCCGAAGGGAATTTACCCGTGCAAGCATCGAAAGCAAGATAGAGGAGACCCCTC
AGGCGCAATGGCCGGTGCATGCGGTTATCACCAATTCGACTTACGATGGTCTGCTGTATAACACTAACTGGATCAAGCAA
ATGCTGGACGTTCCCTCGATCCATTTTGATTCCGCCTGGGTACCCTATACCCATTTCCATCCGATCTACCAGGGGAAAAG
CGGGATGAGCGGCGATCGGGTGCCCGGAAAAGTGATTTTCGAAACGCAATCCACCCATAAAATGCTGGCGGCTTTTTCGC
AGGCGTCGCTTATTCATATCAAAGGGGAATATGACGAAGAGACGTTTAACGAAGCGTTTATGATGCACACTTCCACATCG
CCGAGCTATCCCATTGTCGCCTCTATCGAGACCGCAGCGGCGATGCTGCGCGGCAATCCAGGGAAAAGATTGATTAATCG
TTCGGTGGAACGGGCGCTCCATTTTCGTAAAGAGGTACAGCGGCTACGTGAAGAGTCCGATAGCTGGTTCTTTGATATCT
GGCAGCCGGAAGAGGTTGATGAGGCCGAATGCTGGCCGGTCACGCCGGGAGAAACCTGGCATGGCTTCACCGATGCCGAT
GACGATCATATGTTCCTCGATCCGGTTAAGGTGACAATCCTGACGCCGGGGATGGATGAACAGGGCAACATGAGCGAAGA
GGGGATACCCGCCGCGCTGGTGGCGAAGTTCCTTGATGAGCGAGGCGTGGTGGTGGAAAAAACCGGGCCGTATAATCTGC
TGTTTTTGTTCAGCATAGGGATTGATAAGACCCGTGCGATGGGGCTGCTGCGCGGACTGACGGAATTTAAACGCGCCTAC
GATCTTAACCTGCGCGTCAAAAATATGTTGCCGGATCTGTATGCGGAAGATCCGGATTTTTATCGCAATATGCGCATTCA
GGATCTGGCGCAGGGGATCCATAAACTGATCCGCCAGCACGATCTTCCGGGGCTGATGCTGCGGGCGTTCGAGGTTTTAC
CGGAGATGATCATGACCCCGCACCAGGCCTGGCAGCGTCAGATCAAAGGTGAGGTGGAAACCGTGGCGCTCGATCAACTG
CCAGGGCGCGTTTCCGCGAATATGATCCTGCCTTATCCGCCAGGCGTTCCGCTGTTGATGCCCGGCGAGAGGATCACGCA
ACAGAGTCGGGCCGTGCTCGATTTTCTGCTGATGCTCTGCTCGATTGGCCAGCATTATCCCGGTTTTGAAACGGATATTC
ACGGCGCGAAACGGAATGAAGACGGGGTGTACCAGGTACGAGTCTTAAAACACGCCTGCTAG

Upstream 100 bases:

>100_bases
GGCCGATGCATGGAACGCATTGTAATAAGATAAATCCTGTCGGTGCTTTGCATCGGCAGGATTGTTACTATGCTTATCTC
AGGTTTTTTCAGGAGAAAGC

Downstream 100 bases:

>100_bases
CTTGCCTGACGGGAATGTGACGAGTAACGTACTGATAATCAATAAAGGAGACGCTATGCTGGGATTAAAACAGGTTCATC
ACATCGCGATCATTGCGACA

Product: lysine decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSEINQLNEYLPLY
AFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQYTNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTAYQK
SPPGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRASIESKIEETPQAQWPVHAVITNSTYDGLLYNTNWIKQ
MLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIFETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQHDLPGLMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQL
PGRVSANMILPYPPGVPLLMPGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC

Sequences:

>Translated_713_residues
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSEINQLNEYLPLY
AFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQYTNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTAYQK
SPPGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRASIESKIEETPQAQWPVHAVITNSTYDGLLYNTNWIKQ
MLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIFETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQHDLPGLMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQL
PGRVSANMILPYPPGVPLLMPGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC
>Mature_713_residues
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSEINQLNEYLPLY
AFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQYTNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTAYQK
SPPGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRASIESKIEETPQAQWPVHAVITNSTYDGLLYNTNWIKQ
MLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIFETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQHDLPGLMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQL
PGRVSANMILPYPPGVPLLMPGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC

Specific function: LDC is constitutively but weakly expressed under various conditions [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=712, Percent_Identity=91.1516853932584, Blast_Score=1376, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=710, Percent_Identity=70.9859154929578, Blast_Score=1108, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=720, Percent_Identity=35.1388888888889, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI87082193, Length=620, Percent_Identity=34.3548387096774, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1786909, Length=696, Percent_Identity=32.0402298850575, Blast_Score=304, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80764; Mature: 80764

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSEINQLNEYLPLYAFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQY
CCCHHHHHHHHHHHHCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTAYQKSPPGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRASIESKIEETPQAQWPVH
ECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTNWIKQMLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIF
EEEECCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTSPSYPIVASIETAAAMLRGNP
ECCHHHHHHHHHCCCEEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLPGLMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQLPGRVSANMILPYPPGVPLLM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCCCCCEEC
PGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHCC
>Mature Secondary Structure
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSEINQLNEYLPLYAFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQY
CCCHHHHHHHHHHHHCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTAYQKSPPGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRASIESKIEETPQAQWPVH
ECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTNWIKQMLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIF
EEEECCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTSPSYPIVASIETAAAMLRGNP
ECCHHHHHHHHHCCCEEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLPGLMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQLPGRVSANMILPYPPGVPLLM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCCCCCEEC
PGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226257; 9339543; 9278503; 9723924 [H]