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The map label for this gene is wecA

Identifier: 218930869

GI number: 218930869

Start: 4340131

End: 4341228

Strand: Reverse

Name: wecA

Synonym: YPO3866

Alternate gene names: 218930869

Gene position: 4341228-4340131 (Counterclockwise)

Preceding gene: 218930870

Following gene: 218930868

Centisome position: 93.28

GC content: 46.9

Gene sequence:

>1098_bases
GTGAACCTACTCACTATGAGTACTGAATTAATTTATATCTTTCTGTTTTCTATGGCATTTCTATTTGTTGCTCGCAAAGT
TGCCATAAAAATTGGACTTGTCGATAAACCCAACTACCGTAAGCGCCATCAAGGATTAATCCCTCTGGTGGGGGGAATAT
CGGTATTCGCGGGGGTCTGTTTTGCTTTTCTGATTACTAATCAGCAAATTCCCCATTTTCGTTTATATCTTGCATGTGCC
GGGTTATTGGTCTTCGTTGGTGCTTTAGATGATCGTTTTGATATCAGCGTAAAAATTCGCGCTTTTGTTCAAGCACTGGT
CGGCATCGCGATGATGGCAGTCGCGGGGCTATATTTACGTAGTCTGGGGCATGCCTTCGGTCCATGGGAAATGGTATTAG
GGCCATTTGGTTATGTGGTCACCCTGTTTGCGGTTTGGGCGGCCATCAATGCGTTCAACATGGTTGATGGAATAGATGGC
TTGCTGGGTGGCCTATCCTGTGTTTCCTTCGGGGCCATGGGGATTTTGTTGTACCAAAGTGGGCAGATGTCATTGGCGTT
ATGGTGTTTCGCCATGATAGCCACCATTATTCCCTATATCTTACTGAATCTCGGGTTACTGGGTCGCCGCTATAAAGTCT
TCATGGGCGATGCTGGCAGTACTTTGATTGGTTTCACCGCGATCTGGATCCTGTTACAGGCGACTCAGGGTAATGCTCAT
CCGATCAACCCTGTGACGGCACTATGGATTATCGCCATTCCGTTGATGGACATGATTGCCATCATGTATCGTCGTTTACG
CAAAGGCATGAGTCCTTTCTCTCCAGATCGCCAACATATTCATCATTTAATCATGCGGGCCGGTTTTACCTCCCGGCAAG
CTTTTGTCCTCATCACACTGGCTGCCGCGTTGTTAGCCATGATTGGTGTTATCGGCGAACGGCTGACATTTATACCCGAA
TGGGTCATGTTGGCATTGTTCTTGCTTGCATTTCTATTGTATGGCTACTGCATTAAACGGGCATGGCGGGTGGCGCGTTT
TATCAAACGTTTCAAGCGTCGGATGCGGCGGGCATCGAAAAATAAGCATGAATCTTAA

Upstream 100 bases:

>100_bases
CTATCATCATATTCAGATATAACTGAAAGCGTGTTGGGGGCATAGCAAGTGCTAATCTACATGCTAAGCTGTTGTATCTT
TTTGCAGAGAGCGGTTAAAC

Downstream 100 bases:

>100_bases
CCAGAGGCTTTTAGGCAGTGATGAAACCAGAATCTATGTCGACTGATAAAACAGGGTCTACCAATAATGAACCGTCTGTG
GATAACGAATTAGATATCCG

Product: putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNLLTMSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLITNQQIPHFRLYLACA
GLLVFVGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDG
LLGGLSCVSFGAMGILLYQSGQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAH
PINPVTALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLAMIGVIGERLTFIPE
WVMLALFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES

Sequences:

>Translated_365_residues
MNLLTMSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLITNQQIPHFRLYLACA
GLLVFVGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDG
LLGGLSCVSFGAMGILLYQSGQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAH
PINPVTALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLAMIGVIGERLTFIPE
WVMLALFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES
>Mature_365_residues
MNLLTMSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLITNQQIPHFRLYLACA
GLLVFVGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDG
LLGGLSCVSFGAMGILLYQSGQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAH
PINPVTALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLAMIGVIGERLTFIPE
WVMLALFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily

Homologues:

Organism=Escherichia coli, GI1790218, Length=349, Percent_Identity=81.0888252148997, Blast_Score=536, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECA_YERPE (Q8ZAE1)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0471
- RefSeq:   NP_667700.1
- RefSeq:   NP_994470.1
- RefSeq:   YP_002348744.1
- ProteinModelPortal:   Q8ZAE1
- IntAct:   Q8ZAE1
- GeneID:   1145309
- GeneID:   1176705
- GeneID:   2766489
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3866
- KEGG:   ypk:y0362
- KEGG:   ypm:YP_3179
- HOGENOM:   HBG536396
- OMA:   LWIISIT
- ProtClustDB:   PRK15119
- BioCyc:   YPES187410:Y0362-MONOMER
- BioCyc:   YPES214092:YPO3866-MONOMER
- InterPro:   IPR012750
- InterPro:   IPR000715
- PANTHER:   PTHR22926
- TIGRFAMs:   TIGR02380

Pfam domain/function: PF00953 Glycos_transf_4

EC number: 2.7.8.- [C]

Molecular weight: Translated: 40767; Mature: 40767

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18ae60cc)-; HASH(0x18c4f104)-; HASH(0x18d9ea8c)-; HASH(0x18c68904)-; HASH(0x18e8baa4)-; HASH(0x18e59758)-; HASH(0x18e9649c)-; HASH(0x18e9f688)-; HASH(0x18e045a0)-; HASH(0x18f7635c)-; HASH(0x18caba68)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLTMSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVC
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCHHHHHHHHHHHHH
FAFLITNQQIPHFRLYLACAGLLVFVGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDGLLGGLSCVSFGAMGILLYQS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
PINPVTALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
AAALLAMIGVIGERLTFIPEWVMLALFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NKHES
CCCCH
>Mature Secondary Structure
MNLLTMSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVC
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCHHHHHHHHHHHHH
FAFLITNQQIPHFRLYLACAGLLVFVGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDGLLGGLSCVSFGAMGILLYQS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
PINPVTALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
AAALLAMIGVIGERLTFIPEWVMLALFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NKHES
CCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430