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The map label for this gene is hemC [H]

Identifier: 218930852

GI number: 218930852

Start: 4319664

End: 4320605

Strand: Direct

Name: hemC [H]

Synonym: YPO3849

Alternate gene names: 218930852

Gene position: 4319664-4320605 (Clockwise)

Preceding gene: 218930850

Following gene: 218930853

Centisome position: 92.82

GC content: 54.78

Gene sequence:

>942_bases
ATGTTAGACAAAATTATTCGAATTGCCACACGACAAAGCCCGCTCGCCTTATGGCAAGCACATTATGTTCAACATTTATT
GCAAGCCAATCACCCTGGTCTGCAAATCGAACTGGTCCCAATGGTCACCCGTGGGGATATCATTTTGGATACACCATTGG
CCAAAGTCGGTGGTAAGGGTTTATTTGTCAAAGAATTAGAGCTGGCGCTGCTGGACGGCAGAGCTGATATTGCCGTGCAT
TCGATGAAAGATGTGCCCATTGCTTTCCCCGAAGGGCTGGGTTTAGTCACGATTTGTGAACGTGAAGACCCGCGCGATGC
TTTCGTCTCGTCACATTATGCCCATCTGGATGATCTCCCTGCAGGCAGTGTTGTCGGTACCTCCAGCCTGCGCCGCCAGT
GTCAGCTACGCGAACGGCGACCAGACCTGATTATCCGCGATCTACGGGGCAACGTCGGTACCCGCCTTGCCAAACTGGAT
AATGGTGACTATCAGGCTATTATTCTGGCTGTCGCGGGTCTCAAGCGCCTCGGTCTGGAAAACCGAATTCGCTATGCCAT
GTCAGCGGAGGAGTCCCTCCCGGCTGTCGGCCAAGGTGCCGTAGGTATCGAATGCCGTCTGGATGATGACCATACCCGCC
AGTTGCTGGCTCCGTTGAACCATCGGCACACCGAATTACGGGTCTGTGCGGAGCGGGCAATGAATATTCGCCTTGAAGGG
GGTTGCCAAGTCCCGATCGGTAGCTACGCTGAACTGGAAGGTGATACTTTATGGCTACGGGCGCTGGTGGGAGCACCTGA
TGGCAGCCAAATGATCCGGGGTGAACGCCGTGGTCCGGCGGCAGAGGCTGAGCAGATGGGCATTGAACTTGCCGATGAGT
TGCTATCACGCGGCGCACGAGAAATCCTGGCGGCGGTTTATCTGGATAATCCTGCGCGATGA

Upstream 100 bases:

>100_bases
TTTTTTAGGCATTTATCCGCCCTGTTCATACGGCTATTACACTGACAGTGTTCACCGGTCAGTGATAGGATGGGCCGTAA
AATATAAAACGGTAACAAGC

Downstream 100 bases:

>100_bases
CAATCCTGGTCACCCGTCCATCCCCTGCTGGGGAGCAATTAGTCACTCGCCTGCGTGCTCTGGGCCGGGTTGCCTACCAT
GCGCCATTGATTGATTTTTC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLDGRADIAVH
SMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLPAGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLD
NGDYQAIILAVAGLKRLGLENRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEG
GCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAREILAAVYLDNPAR

Sequences:

>Translated_313_residues
MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLDGRADIAVH
SMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLPAGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLD
NGDYQAIILAVAGLKRLGLENRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEG
GCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAREILAAVYLDNPAR
>Mature_313_residues
MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLDGRADIAVH
SMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLPAGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLD
NGDYQAIILAVAGLKRLGLENRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEG
GCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAREILAAVYLDNPAR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=333, Percent_Identity=42.9429429429429, Blast_Score=237, Evalue=8e-63,
Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=42.9429429429429, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI48994974, Length=313, Percent_Identity=80.5111821086262, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=39.1849529780564, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI20130425, Length=260, Percent_Identity=44.2307692307692, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34336; Mature: 34336

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKG
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEECCHHHHCCCC
LFVKELELALLDGRADIAVHSMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLP
EEEEEEEEEEECCCCCEEEECCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC
AGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLDNGDYQAIILAVAGLKRLGLE
CCCEECCHHHHHHHHHHHCCCCEEEEECCCCHHHEEEECCCCCHHHHHHHHHHHHHHCHH
NRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEG
HHHHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHEEEECC
GCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAR
CCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EILAAVYLDNPAR
HHHHHHHCCCCCC
>Mature Secondary Structure
MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKG
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEECCHHHHCCCC
LFVKELELALLDGRADIAVHSMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLP
EEEEEEEEEEECCCCCEEEECCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC
AGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLDNGDYQAIILAVAGLKRLGLE
CCCEECCHHHHHHHHHHHCCCCEEEEECCCCHHHEEEECCCCCHHHHHHHHHHHHHHCHH
NRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEG
HHHHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHEEEECC
GCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAR
CCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EILAAVYLDNPAR
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA