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The map label for this gene is ubiB [H]

Identifier: 218930781

GI number: 218930781

Start: 4241170

End: 4242801

Strand: Reverse

Name: ubiB [H]

Synonym: YPO3779

Alternate gene names: 218930781

Gene position: 4242801-4241170 (Counterclockwise)

Preceding gene: 218930782

Following gene: 218930780

Centisome position: 91.17

GC content: 46.02

Gene sequence:

>1632_bases
ATGACGCCAGGAGAACTTCGGCGCCTGTATTTAATTATTCGGGTCTTCTTGAGTTATGGGTTGGATGAATTAATTCCGAA
TATACGTCTGACGCTACCACTACGGGTTGGGCGTCATCTGTTTTTTTGGTTATCTAACCGGCATAAAGATAAGTCATTAG
GTGAGCGTTTACGTCTTGCTTTGCAGGAGTTGGGACCTGTCTGGATCAAATTCGGCCAAATGATGTCCACGCGCCGCGAC
TTGTTTCCTCCAAATATTGCCGATCAATTAGCTCTGTTACAAGATCGGGTCGCTTCTTTTGATGGTGCGCTAGCGCGTAA
GCATATTGAGATTGCGATGGGGGGGGCGTTAGAAACATGGTTTGATGATTTTGATTCGCAAGCGCTAGCTTCAGCCTCTA
TTGCCCAAGTACATACTGCACGCTTAAAAGAGAATGGTAAGGAAGTCGTACTTAAGGTTATTCGCCCTGATATCCTGCCG
ATTATTAAAGCTGATGTACGTTTAATGTATCGTTTAGCTGGCTGGGTACCAAAGCTTTTACCTGATGGTCGCAGATTACG
CCCGCGTGAAGTTGTTCGTGAATATGAAAAAACGCTGCTTGATGAACTGAATCTTCTGCGTGAAGCAGCGAATGCCATTC
AACTGCGTCGTAATTTTGAAGACAGTCCAATGCTCTACATTCCCGAGGTGTACTCGGACTATTGTCGTGAAAGCGTATTA
GTCATGGAGCGGATTTACGGTATCCCGGTATCTGATATTGCTGCTTTAGAAGACCAAGGTACCAATATGAAGTTACTGGC
AGAGCGCGGGGTGCAAGTCTTTTTCACCCAGGTTTTCCGTGACAGCTTCTTCCACGCAGATATGCATCCGGGGAATATTT
TTGTCAGCTATGAACATCCTCATGACCCGCTTTATATTGGTATTGATTGCGGTATTGTTGGCTCACTGAATAAAGCCGAT
AAACGTTATCTGGCTGAGAACTTTATTGCTTTCTTTAACCGCGATTACCGCCGGGTTGCTGAGCTACATGTGGACTCTGG
CTGGGTACCTCGAGATACCAATGTCGAAGATTTTGAATTCGCCATCCGTACCGTTTGTGAACCTATCTTTGAAAAACCAC
TGGCAGAAATATCATTTGGGCATGTGTTGCTGAATCTCTTCAACACCGCGCGCCGTTTTAATATGGAAGTACAGCCACAG
TTAGTTCTATTACAGAAAACCTTGTTATACGTTGAAGGGCTAGGGCGTCAGCTTTATCCTCAGCTTGATCTCTGGACTAC
CGCTAAGCCGTTTCTGGAAAGTTGGCTGCGGGACCAGGTCGGTCTACCTGCCGTAATTCGTGCATTAAAAGAGAAAGCCC
CTTTCTGGGCTGAAAAATTCCCTGAGCTACCAGAACTGGTTTACGACAGCTTACAGCAGCATAAATTATTACAACAAAGT
GTGGAGAAGCTCACTATACAGATACAAGGTCAGCAACAACGTCAGGGGCAGTCACGGTATTTGTTCGGTGTTGGCGCTAC
ACTATTAGTGAGCGGTACTATCTTATTCTTGGCCGATGCAACCGAAGTCTCTACAGGGTTCATCGTTGCCGGTGCATTGG
CTTGGTTTATCGGTTGGCGACGTACCTGCTAA

Upstream 100 bases:

>100_bases
CCAACCTGCTGGAAGTCATGTGGTTTCATGAAGAAGTCGATGCAACCGCTCGTGCAACCGAAGCTTTGAGTTCCAGATTG
GCAACTATGGAGACAAAATA

Downstream 100 bases:

>100_bases
ATTATTTATCGCGAAGAATGTTGGGTTATGGGTTATTGCATAACCGTGAGTTATATAAACTTGTTCAATAAGCTATGAAC
TAGTTCAAAATGCGGTAAGT

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MTPGELRRLYLIIRVFLSYGLDELIPNIRLTLPLRVGRHLFFWLSNRHKDKSLGERLRLALQELGPVWIKFGQMMSTRRD
LFPPNIADQLALLQDRVASFDGALARKHIEIAMGGALETWFDDFDSQALASASIAQVHTARLKENGKEVVLKVIRPDILP
IIKADVRLMYRLAGWVPKLLPDGRRLRPREVVREYEKTLLDELNLLREAANAIQLRRNFEDSPMLYIPEVYSDYCRESVL
VMERIYGIPVSDIAALEDQGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPHDPLYIGIDCGIVGSLNKAD
KRYLAENFIAFFNRDYRRVAELHVDSGWVPRDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWTTAKPFLESWLRDQVGLPAVIRALKEKAPFWAEKFPELPELVYDSLQQHKLLQQS
VEKLTIQIQGQQQRQGQSRYLFGVGATLLVSGTILFLADATEVSTGFIVAGALAWFIGWRRTC

Sequences:

>Translated_543_residues
MTPGELRRLYLIIRVFLSYGLDELIPNIRLTLPLRVGRHLFFWLSNRHKDKSLGERLRLALQELGPVWIKFGQMMSTRRD
LFPPNIADQLALLQDRVASFDGALARKHIEIAMGGALETWFDDFDSQALASASIAQVHTARLKENGKEVVLKVIRPDILP
IIKADVRLMYRLAGWVPKLLPDGRRLRPREVVREYEKTLLDELNLLREAANAIQLRRNFEDSPMLYIPEVYSDYCRESVL
VMERIYGIPVSDIAALEDQGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPHDPLYIGIDCGIVGSLNKAD
KRYLAENFIAFFNRDYRRVAELHVDSGWVPRDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWTTAKPFLESWLRDQVGLPAVIRALKEKAPFWAEKFPELPELVYDSLQQHKLLQQS
VEKLTIQIQGQQQRQGQSRYLFGVGATLLVSGTILFLADATEVSTGFIVAGALAWFIGWRRTC
>Mature_542_residues
TPGELRRLYLIIRVFLSYGLDELIPNIRLTLPLRVGRHLFFWLSNRHKDKSLGERLRLALQELGPVWIKFGQMMSTRRDL
FPPNIADQLALLQDRVASFDGALARKHIEIAMGGALETWFDDFDSQALASASIAQVHTARLKENGKEVVLKVIRPDILPI
IKADVRLMYRLAGWVPKLLPDGRRLRPREVVREYEKTLLDELNLLREAANAIQLRRNFEDSPMLYIPEVYSDYCRESVLV
MERIYGIPVSDIAALEDQGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPHDPLYIGIDCGIVGSLNKADK
RYLAENFIAFFNRDYRRVAELHVDSGWVPRDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQL
VLLQKTLLYVEGLGRQLYPQLDLWTTAKPFLESWLRDQVGLPAVIRALKEKAPFWAEKFPELPELVYDSLQQHKLLQQSV
EKLTIQIQGQQQRQGQSRYLFGVGATLLVSGTILFLADATEVSTGFIVAGALAWFIGWRRTC

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=277, Percent_Identity=28.5198555956679, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI32261307, Length=316, Percent_Identity=26.2658227848101, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI40254938, Length=234, Percent_Identity=29.0598290598291, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI217035081, Length=180, Percent_Identity=31.6666666666667, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI34147522, Length=213, Percent_Identity=29.5774647887324, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI2367309, Length=545, Percent_Identity=80.7339449541284, Blast_Score=914, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=232, Percent_Identity=28.448275862069, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI32565180, Length=305, Percent_Identity=25.9016393442623, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=440, Percent_Identity=24.0909090909091, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=26.5060240963855, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=209, Percent_Identity=24.4019138755981, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24662575, Length=245, Percent_Identity=31.4285714285714, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI22024280, Length=252, Percent_Identity=30.5555555555556, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62428; Mature: 62297

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGELRRLYLIIRVFLSYGLDELIPNIRLTLPLRVGRHLFFWLSNRHKDKSLGERLRLA
CCCHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEHHHCCHHEEECCCCCCCHHHHHHHHHH
LQELGPVWIKFGQMMSTRRDLFPPNIADQLALLQDRVASFDGALARKHIEIAMGGALETW
HHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHH
FDDFDSQALASASIAQVHTARLKENGKEVVLKVIRPDILPIIKADVRLMYRLAGWVPKLL
HHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
PDGRRLRPREVVREYEKTLLDELNLLREAANAIQLRRNFEDSPMLYIPEVYSDYCRESVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHH
VMERIYGIPVSDIAALEDQGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHP
HHHHHHCCCHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
HDPLYIGIDCGIVGSLNKADKRYLAENFIAFFNRDYRRVAELHVDSGWVPRDTNVEDFEF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
AIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWTTAKPFLESWLRDQVGLPAVIRALKEKAPFWAEKFPELPELVYDSLQQHKLLQQS
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH
VEKLTIQIQGQQQRQGQSRYLFGVGATLLVSGTILFLADATEVSTGFIVAGALAWFIGWR
HHHEEEEEECCHHCCCCCCEEEECCHHHHHHCEEEEEECCCHHCCHHHHHHHHHHHHHHH
RTC
CCC
>Mature Secondary Structure 
TPGELRRLYLIIRVFLSYGLDELIPNIRLTLPLRVGRHLFFWLSNRHKDKSLGERLRLA
CCHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEHHHCCHHEEECCCCCCCHHHHHHHHHH
LQELGPVWIKFGQMMSTRRDLFPPNIADQLALLQDRVASFDGALARKHIEIAMGGALETW
HHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHH
FDDFDSQALASASIAQVHTARLKENGKEVVLKVIRPDILPIIKADVRLMYRLAGWVPKLL
HHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
PDGRRLRPREVVREYEKTLLDELNLLREAANAIQLRRNFEDSPMLYIPEVYSDYCRESVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHH
VMERIYGIPVSDIAALEDQGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHP
HHHHHHCCCHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
HDPLYIGIDCGIVGSLNKADKRYLAENFIAFFNRDYRRVAELHVDSGWVPRDTNVEDFEF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
AIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWTTAKPFLESWLRDQVGLPAVIRALKEKAPFWAEKFPELPELVYDSLQQHKLLQQS
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH
VEKLTIQIQGQQQRQGQSRYLFGVGATLLVSGTILFLADATEVSTGFIVAGALAWFIGWR
HHHEEEEEECCHHCCCCCCEEEECCHHHHHHCEEEEEECCCHHCCHHHHHHHHHHHHHHH
RTC
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA