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The map label for this gene is pepQ [H]

Identifier: 218930769

GI number: 218930769

Start: 4227165

End: 4228496

Strand: Reverse

Name: pepQ [H]

Synonym: YPO3765

Alternate gene names: 218930769

Gene position: 4228496-4227165 (Counterclockwise)

Preceding gene: 218930772

Following gene: 218930768

Centisome position: 90.86

GC content: 45.35

Gene sequence:

>1332_bases
ATGGAAACGCTGGCTTCTTTATATAACGAACATTTATCCACTCTACAACAGCGCACCCGCGATGTGCTGGAGCGTCATCA
ATTAGATGCGTTGCTGATTCACTCTGGTGAATTACAGCGGCTTTTTCTTGATGACCGTGACTATCCCTTTAAGGTTAATC
CACAGTTTAAAGCTTGGGTCCCTGTGACTGAGGTCCCCAATTGCTGGTTATGGGTTGATGGAGTCAATACACCAAAATTA
TGGTTCTACTCACCGGTAGATTACTGGCACAGTGTCGAACCGCTACCTGATAGCTTCTGGACGAAGAATATTGATGTTCA
GCCATTGCTGAATGCTGATGATATTGCGCAACAATTACCTGTTCAGCGTGAACGTGTTGCTTATATTGGTTATGCCCAGC
AGCGTGCACAAGCTTTAGGCTTCAGTGCTGAGAACATTAACCCGCAGCCGGTCTTGGATTATCTTCATTATTATCGCTCT
TATAAAACGGATTACGAACTGGCGTGCATGCGTGAAGCACAAAAAACTGCAGTCGTAGGGCATCGTGCGGCCTATGAAGC
ATTCCAGTCGGGTATGAGTGAGTTTGATATTAATCTGGCTTACCTGATGGCTACCGGACATCGTGATACTGATGTTCCTT
ACGATAATATTGTCGCGCTGAATGAACACTCCGCAGTACTTCATTATACGATTTTACAGCATCAACCTCCGGCAGAGATA
CGTAGTTTCCTGATTGATGCCGGAGCTGAATATAATGGCTATGCTGCCGATCTGACTCGTACTTACACAGCAGACCGTGA
CAGTGATTTTGCGGCTTTAATTAGCGACCTTAATACTGAGCAATTGGCGCTGATCGATACGATTAAAAGTGGTGAACGCT
ATACTGATTATCACGTTCAGATGCATCAACGCATTGCTAAGCTTTTGCGTACACATAATTTAGTCACGGGGATCAGCGAA
GAGGCGATGGTCGAACAGGGAATTACCTGCCCATTCCTGCCACATGGTTTGGGTCATCCACTTGGTTTGCAAGTGCATGA
TACTGCTGGTTTTATGCAGGACGATAAAGGTACGAACCTGAACGCGCCATCTAAGTATCCTTATCTACGTTGCACACGTG
TTCTGCAACCGCGCATGGTGCTGACTATTGAGCCGGGCCTGTACTTTATCGATTCTTTGTTGGCTCCTTGGCGCATTGGT
GAGTTCAGCAAACATTTTAATTGGGATCGTATTGATGCACTGAAGCCTTATGGTGGTATTCGTATAGAAGACAATATTGT
TATTCATGATAAACGGGTCGAAAATATGACGCGTGATCTGAAACTGGCCTGA

Upstream 100 bases:

>100_bases
TATAGTGGCTATCAATTTGTAGAATAAACGTCATCGAAACATGGTTTCGGTGACTATGATAAGATAAAAAAATTAAGTTC
TAATAGCGAAGGGTACTGTG

Downstream 100 bases:

>100_bases
TGCAGCCTTATCTGATACCCGCTATGCCGGTTACTATCAGCGAAGAGATCAAGAAAAGCCGTTTCATTACCTTATTGGCT
CATACCTGTGGGGTTAATGA

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
METLASLYNEHLSTLQQRTRDVLERHQLDALLIHSGELQRLFLDDRDYPFKVNPQFKAWVPVTEVPNCWLWVDGVNTPKL
WFYSPVDYWHSVEPLPDSFWTKNIDVQPLLNADDIAQQLPVQRERVAYIGYAQQRAQALGFSAENINPQPVLDYLHYYRS
YKTDYELACMREAQKTAVVGHRAAYEAFQSGMSEFDINLAYLMATGHRDTDVPYDNIVALNEHSAVLHYTILQHQPPAEI
RSFLIDAGAEYNGYAADLTRTYTADRDSDFAALISDLNTEQLALIDTIKSGERYTDYHVQMHQRIAKLLRTHNLVTGISE
EAMVEQGITCPFLPHGLGHPLGLQVHDTAGFMQDDKGTNLNAPSKYPYLRCTRVLQPRMVLTIEPGLYFIDSLLAPWRIG
EFSKHFNWDRIDALKPYGGIRIEDNIVIHDKRVENMTRDLKLA

Sequences:

>Translated_443_residues
METLASLYNEHLSTLQQRTRDVLERHQLDALLIHSGELQRLFLDDRDYPFKVNPQFKAWVPVTEVPNCWLWVDGVNTPKL
WFYSPVDYWHSVEPLPDSFWTKNIDVQPLLNADDIAQQLPVQRERVAYIGYAQQRAQALGFSAENINPQPVLDYLHYYRS
YKTDYELACMREAQKTAVVGHRAAYEAFQSGMSEFDINLAYLMATGHRDTDVPYDNIVALNEHSAVLHYTILQHQPPAEI
RSFLIDAGAEYNGYAADLTRTYTADRDSDFAALISDLNTEQLALIDTIKSGERYTDYHVQMHQRIAKLLRTHNLVTGISE
EAMVEQGITCPFLPHGLGHPLGLQVHDTAGFMQDDKGTNLNAPSKYPYLRCTRVLQPRMVLTIEPGLYFIDSLLAPWRIG
EFSKHFNWDRIDALKPYGGIRIEDNIVIHDKRVENMTRDLKLA
>Mature_443_residues
METLASLYNEHLSTLQQRTRDVLERHQLDALLIHSGELQRLFLDDRDYPFKVNPQFKAWVPVTEVPNCWLWVDGVNTPKL
WFYSPVDYWHSVEPLPDSFWTKNIDVQPLLNADDIAQQLPVQRERVAYIGYAQQRAQALGFSAENINPQPVLDYLHYYRS
YKTDYELACMREAQKTAVVGHRAAYEAFQSGMSEFDINLAYLMATGHRDTDVPYDNIVALNEHSAVLHYTILQHQPPAEI
RSFLIDAGAEYNGYAADLTRTYTADRDSDFAALISDLNTEQLALIDTIKSGERYTDYHVQMHQRIAKLLRTHNLVTGISE
EAMVEQGITCPFLPHGLGHPLGLQVHDTAGFMQDDKGTNLNAPSKYPYLRCTRVLQPRMVLTIEPGLYFIDSLLAPWRIG
EFSKHFNWDRIDALKPYGGIRIEDNIVIHDKRVENMTRDLKLA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=466, Percent_Identity=28.1115879828326, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI260593665, Length=325, Percent_Identity=30.7692307692308, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI260593663, Length=323, Percent_Identity=29.7213622291022, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=73.5891647855531, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=308, Percent_Identity=29.2207792207792, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=292, Percent_Identity=33.9041095890411, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321118, Length=295, Percent_Identity=31.1864406779661, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320922, Length=300, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21357079, Length=298, Percent_Identity=30.2013422818792, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19920384, Length=297, Percent_Identity=27.6094276094276, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 50912; Mature: 50912

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLASLYNEHLSTLQQRTRDVLERHQLDALLIHSGELQRLFLDDRDYPFKVNPQFKAWV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTEVPNCWLWVDGVNTPKLWFYSPVDYWHSVEPLPDSFWTKNIDVQPLLNADDIAQQLP
CCCCCCCCEEEEECCCCCCEEEECCHHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHCC
VQRERVAYIGYAQQRAQALGFSAENINPQPVLDYLHYYRSYKTDYELACMREAQKTAVVG
CCHHHEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HRAAYEAFQSGMSEFDINLAYLMATGHRDTDVPYDNIVALNEHSAVLHYTILQHQPPAEI
HHHHHHHHHCCHHHHCCEEEEEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHH
RSFLIDAGAEYNGYAADLTRTYTADRDSDFAALISDLNTEQLALIDTIKSGERYTDYHVQ
HHHHHHCCCCCCCEEHHHEEEECCCCCCHHHHHHHCCCCCCEEEHHHHHCCCCCHHHHHH
MHQRIAKLLRTHNLVTGISEEAMVEQGITCPFLPHGLGHPLGLQVHDTAGFMQDDKGTNL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
NAPSKYPYLRCTRVLQPRMVLTIEPGLYFIDSLLAPWRIGEFSKHFNWDRIDALKPYGGI
CCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHCCCCHHHCCCCCCCE
RIEDNIVIHDKRVENMTRDLKLA
EEECCEEEECHHHHHHHHHCCCC
>Mature Secondary Structure
METLASLYNEHLSTLQQRTRDVLERHQLDALLIHSGELQRLFLDDRDYPFKVNPQFKAWV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTEVPNCWLWVDGVNTPKLWFYSPVDYWHSVEPLPDSFWTKNIDVQPLLNADDIAQQLP
CCCCCCCCEEEEECCCCCCEEEECCHHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHCC
VQRERVAYIGYAQQRAQALGFSAENINPQPVLDYLHYYRSYKTDYELACMREAQKTAVVG
CCHHHEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HRAAYEAFQSGMSEFDINLAYLMATGHRDTDVPYDNIVALNEHSAVLHYTILQHQPPAEI
HHHHHHHHHCCHHHHCCEEEEEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHH
RSFLIDAGAEYNGYAADLTRTYTADRDSDFAALISDLNTEQLALIDTIKSGERYTDYHVQ
HHHHHHCCCCCCCEEHHHEEEECCCCCCHHHHHHHCCCCCCEEEHHHHHCCCCCHHHHHH
MHQRIAKLLRTHNLVTGISEEAMVEQGITCPFLPHGLGHPLGLQVHDTAGFMQDDKGTNL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
NAPSKYPYLRCTRVLQPRMVLTIEPGLYFIDSLLAPWRIGEFSKHFNWDRIDALKPYGGI
CCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHCCCCHHHCCCCCCCE
RIEDNIVIHDKRVENMTRDLKLA
EEECCEEEECHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA