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The map label for this gene is folP [H]

Identifier: 218930515

GI number: 218930515

Start: 3911226

End: 3912059

Strand: Reverse

Name: folP [H]

Synonym: YPO3501

Alternate gene names: 218930515

Gene position: 3912059-3911226 (Counterclockwise)

Preceding gene: 218930516

Following gene: 218930514

Centisome position: 84.06

GC content: 47.6

Gene sequence:

>834_bases
ATGCATCTAACTGCCAGAGGTCTGACGTTGGATCTCTCTCGTCCACAAGTCATGGGTATTCTGAATGTCACACCAGATTC
ATTTTCAGATGGTGGGTGTCACAATAACCTTGATCAAGCATTGCAACATGCTCAACGGATGTTATCAGCAGGCGCTACGC
TGATTGATATCGGTGGTGAATCAACGCGCCCTGGGGCTGCTGAAGTCAGTGAGCAAGAAGAACTTGATCGAGTCGTGCCT
GTGGTTGAGGCGTTAGCTCAGCGTTTTGATGTGTGGCTCTCGGTAGACACGTCTAAAGCCGCTGTTATCACTGAATCTGC
TCATGCAGGTGCCCATCTAATTAATGATATCCGCTCGTTGCAAGAGCCTGGCGCTCTTGAAGCAGCGGCAAAGACTGGCT
TACCGGTGTGCCTAATGCATATGCAGGGGCAACCGAAAAATATGCAGCATTCACCCTACTATGATGATTTAATGACCGAT
ATAAATCGGTTCTTCCAACATCATATTGAACGCTGTGTTGCGGCAGGTATCGCAAAAAATAAATTGTTGCTCGACCCAGG
CTTCGGTTTCGGTAAAAATCTGGCGCATAATTACCAACTATTGGCACATCTGTCAGAGCTTCACCATTTTGAGTTGCCAT
TATTGGTCGGAATGTCGAGAAAATCGATGGTAGGCCAATTATTGAATGTACCACCACAACAGCGTGTCATCGGGAGTGTT
GCTTGTGCGGTGATTGCTGCCATGCAAGGTGCGCAGATTATCAGAGTGCATGATGTCAAAGAAACTGTCGAGGCGATGTG
TATCGTCGAGGCAACACGTTCAGCGAAGGGATAA

Upstream 100 bases:

>100_bases
CTAAAAGCGTTGTGACTAATATAACCCTAGGCTTGCCTAGGGTTTTTTTGTTGCTAAATTTAATAACTGAAGTGAATAGC
CACTTTTAAGGCGCAATAAC

Downstream 100 bases:

>100_bases
AGATAAATTATGAGTAACCGTAAATACTTTGGTACAGATGGCATTCGCGGTAAAGTGGGTGAAAGTCCGATTACGCCGGA
TTTTGTATTGAAGCTTGGCT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MHLTARGLTLDLSRPQVMGILNVTPDSFSDGGCHNNLDQALQHAQRMLSAGATLIDIGGESTRPGAAEVSEQEELDRVVP
VVEALAQRFDVWLSVDTSKAAVITESAHAGAHLINDIRSLQEPGALEAAAKTGLPVCLMHMQGQPKNMQHSPYYDDLMTD
INRFFQHHIERCVAAGIAKNKLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGMSRKSMVGQLLNVPPQQRVIGSV
ACAVIAAMQGAQIIRVHDVKETVEAMCIVEATRSAKG

Sequences:

>Translated_277_residues
MHLTARGLTLDLSRPQVMGILNVTPDSFSDGGCHNNLDQALQHAQRMLSAGATLIDIGGESTRPGAAEVSEQEELDRVVP
VVEALAQRFDVWLSVDTSKAAVITESAHAGAHLINDIRSLQEPGALEAAAKTGLPVCLMHMQGQPKNMQHSPYYDDLMTD
INRFFQHHIERCVAAGIAKNKLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGMSRKSMVGQLLNVPPQQRVIGSV
ACAVIAAMQGAQIIRVHDVKETVEAMCIVEATRSAKG
>Mature_277_residues
MHLTARGLTLDLSRPQVMGILNVTPDSFSDGGCHNNLDQALQHAQRMLSAGATLIDIGGESTRPGAAEVSEQEELDRVVP
VVEALAQRFDVWLSVDTSKAAVITESAHAGAHLINDIRSLQEPGALEAAAKTGLPVCLMHMQGQPKNMQHSPYYDDLMTD
INRFFQHHIERCVAAGIAKNKLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGMSRKSMVGQLLNVPPQQRVIGSV
ACAVIAAMQGAQIIRVHDVKETVEAMCIVEATRSAKG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=276, Percent_Identity=75, Blast_Score=433, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=27.1875, Blast_Score=118, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30000; Mature: 30000

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLTARGLTLDLSRPQVMGILNVTPDSFSDGGCHNNLDQALQHAQRMLSAGATLIDIGGE
CCEECCCCEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
STRPGAAEVSEQEELDRVVPVVEALAQRFDVWLSVDTSKAAVITESAHAGAHLINDIRSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCHHHHHHHHHHHHH
QEPGALEAAAKTGLPVCLMHMQGQPKNMQHSPYYDDLMTDINRFFQHHIERCVAAGIAKN
CCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGMSRKSMVGQLLNVPPQQRVIGSV
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCHHHHHHHHH
ACAVIAAMQGAQIIRVHDVKETVEAMCIVEATRSAKG
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHLTARGLTLDLSRPQVMGILNVTPDSFSDGGCHNNLDQALQHAQRMLSAGATLIDIGGE
CCEECCCCEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
STRPGAAEVSEQEELDRVVPVVEALAQRFDVWLSVDTSKAAVITESAHAGAHLINDIRSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCHHHHHHHHHHHHH
QEPGALEAAAKTGLPVCLMHMQGQPKNMQHSPYYDDLMTDINRFFQHHIERCVAAGIAKN
CCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGMSRKSMVGQLLNVPPQQRVIGSV
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCHHHHHHHHH
ACAVIAAMQGAQIIRVHDVKETVEAMCIVEATRSAKG
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]