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The map label for this gene is map [H]

Identifier: 218930358

GI number: 218930358

Start: 3723448

End: 3724233

Strand: Direct

Name: map [H]

Synonym: YPO3337

Alternate gene names: 218930358

Gene position: 3723448-3724233 (Clockwise)

Preceding gene: 218930357

Following gene: 218930360

Centisome position: 80.01

GC content: 51.02

Gene sequence:

>786_bases
ATGACCGAAGTCAAAATCCACTCACCGGCAGAGATTGAAATGGCCCGTGCGGCAGGTCAAGCCGCCGCGAAAGTGCTTGA
AATGATAAAACCCTATGTTCTTGCTGGGATAACGACCGATGAAATTGATCGGCTATGCCACGATTATATCGTTAACGAAC
TGAAGGTTATTCCCGCAAACATTGGCTATCACGGTTATACCCGAACGGTGTGTACCTCGGTCAATCATGTGGTCTGTCAC
GGGATCCCATCCGATAAAAAACTCAAGAACGGCGATATTGTGAATATCGATGTGGCGATCATCAAAGAGGGTTGGTATGG
CGATACCAGCAGAATGTACTTTGTTGGGGAACCCTCAGTCCGGGCCAAACGTCTGGTCGATATTACCTATCAATCCATGG
TGGCTGGCATTAAAGCCGTCCGCCCTGGTGCGACGCTCGGCGACATCGGTGCAAGCATTCAACAGTTGGCTGAGGGCGCA
GGATTTTCTGTAGTGAGAGAATATTGTGGCCACGGTGTGGGTCAGGAATATCATACGGCACCACAGGTTTTGCACTATGG
TATAGCCCAAACGGGCATGCTGCTTAAACCCGGTATGATTTTTACTATCGAACCGATGATTAATGCCGGAAAAGCGGCGA
CCAGCGTACTTTCTGACGGCTGGACGGTTGTGACCAAAGACCGTTCGCTTTCGGCACAGTGGGAACACACCATTGCCGTT
ACCGAATCGGGATACGACCTGCTGACGCCCTGGCCTGAAGGCACTGGCGAATACGAAGCCATCTGA

Upstream 100 bases:

>100_bases
TGGCCCGTGCACTTGTGCAGGTTGAACTGCAAGGCGGAGCGGATATTGCCAAAATGATCTATCCCGATGCTCTTACGCTG
AATAATGGAGAGAAAGCGCA

Downstream 100 bases:

>100_bases
TATCGGCTGTTACCAAACATTTTCATCTGACCAAACATTGTCACCTAACCAAACATTGTTACCTAACCAAACATTGTCAC
CTGAATGCCATTCAAGCCGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTEVKIHSPAEIEMARAAGQAAAKVLEMIKPYVLAGITTDEIDRLCHDYIVNELKVIPANIGYHGYTRTVCTSVNHVVCH
GIPSDKKLKNGDIVNIDVAIIKEGWYGDTSRMYFVGEPSVRAKRLVDITYQSMVAGIKAVRPGATLGDIGASIQQLAEGA
GFSVVREYCGHGVGQEYHTAPQVLHYGIAQTGMLLKPGMIFTIEPMINAGKAATSVLSDGWTVVTKDRSLSAQWEHTIAV
TESGYDLLTPWPEGTGEYEAI

Sequences:

>Translated_261_residues
MTEVKIHSPAEIEMARAAGQAAAKVLEMIKPYVLAGITTDEIDRLCHDYIVNELKVIPANIGYHGYTRTVCTSVNHVVCH
GIPSDKKLKNGDIVNIDVAIIKEGWYGDTSRMYFVGEPSVRAKRLVDITYQSMVAGIKAVRPGATLGDIGASIQQLAEGA
GFSVVREYCGHGVGQEYHTAPQVLHYGIAQTGMLLKPGMIFTIEPMINAGKAATSVLSDGWTVVTKDRSLSAQWEHTIAV
TESGYDLLTPWPEGTGEYEAI
>Mature_260_residues
TEVKIHSPAEIEMARAAGQAAAKVLEMIKPYVLAGITTDEIDRLCHDYIVNELKVIPANIGYHGYTRTVCTSVNHVVCHG
IPSDKKLKNGDIVNIDVAIIKEGWYGDTSRMYFVGEPSVRAKRLVDITYQSMVAGIKAVRPGATLGDIGASIQQLAEGAG
FSVVREYCGHGVGQEYHTAPQVLHYGIAQTGMLLKPGMIFTIEPMINAGKAATSVLSDGWTVVTKDRSLSAQWEHTIAVT
ESGYDLLTPWPEGTGEYEAI

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=248, Percent_Identity=41.1290322580645, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=37.6, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1786364, Length=253, Percent_Identity=56.9169960474308, Blast_Score=317, Evalue=5e-88,
Organism=Escherichia coli, GI1788728, Length=211, Percent_Identity=26.0663507109005, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=255, Percent_Identity=39.2156862745098, Blast_Score=200, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=39.6, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21355531, Length=256, Percent_Identity=42.1875, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=38.3673469387755, Blast_Score=194, Evalue=4e-50,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28278; Mature: 28147

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVKIHSPAEIEMARAAGQAAAKVLEMIKPYVLAGITTDEIDRLCHDYIVNELKVIPAN
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHEEEEECC
IGYHGYTRTVCTSVNHVVCHGIPSDKKLKNGDIVNIDVAIIKEGWYGDTSRMYFVGEPSV
CCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCC
RAKRLVDITYQSMVAGIKAVRPGATLGDIGASIQQLAEGAGFSVVREYCGHGVGQEYHTA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHH
PQVLHYGIAQTGMLLKPGMIFTIEPMINAGKAATSVLSDGWTVVTKDRSLSAQWEHTIAV
HHHHHHHHHHCCEEECCCEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEEEE
TESGYDLLTPWPEGTGEYEAI
EECCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TEVKIHSPAEIEMARAAGQAAAKVLEMIKPYVLAGITTDEIDRLCHDYIVNELKVIPAN
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHEEEEECC
IGYHGYTRTVCTSVNHVVCHGIPSDKKLKNGDIVNIDVAIIKEGWYGDTSRMYFVGEPSV
CCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCC
RAKRLVDITYQSMVAGIKAVRPGATLGDIGASIQQLAEGAGFSVVREYCGHGVGQEYHTA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHH
PQVLHYGIAQTGMLLKPGMIFTIEPMINAGKAATSVLSDGWTVVTKDRSLSAQWEHTIAV
HHHHHHHHHHCCEEECCCEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEEEE
TESGYDLLTPWPEGTGEYEAI
EECCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]