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The map label for this gene is ispA [H]

Identifier: 218930206

GI number: 218930206

Start: 3538713

End: 3539633

Strand: Direct

Name: ispA [H]

Synonym: YPO3176

Alternate gene names: 218930206

Gene position: 3538713-3539633 (Clockwise)

Preceding gene: 218930205

Following gene: 218930207

Centisome position: 76.04

GC content: 50.6

Gene sequence:

>921_bases
ATGTCGGATACCCATGCACCTGTTGATTTTAAACAACAACTTGCCGCTCATCAGCAGCGAGTCAATCAGGCTCTGCTGGA
TTTCATTGCTCCCCTGCCGTTTGGCAACAGCAATTTAATCGAGGCCATGCGCTATGGTGCGGTAATCGGGGGTAAGCGTC
TCCGCCCCTATCTGGTCTATGCCACAGGGCAAATGTTTGGTTTGTCACTCGCCAACTTAGACGCCCCGGCGGCGGCAATT
GAATGTATTCATGCCTATTCATTAATACATGATGATCTGCCCGCCATGGACGATGATGATTTACGCCGTGGGCAGCCGAC
TTGCCACGTTAAGTTTGGCGAGGCCCACGCTATTTTGGCCGGTGATGCACTGCAAACGCTGGCCTTTTCTATTTTGGCTG
AAGCCCCCATGCCCGATGTCGCTGATAAAGATCGCCTATCGATGATTATCGAGTTGGCTCAAGCCAGTGGGGCTGCGGGG
ATGTGTGCGGGTCAGGCGCTAGATCTGGAAGCAGAAACTCGCCCTGTTTTATTAGGTGACCTTGAGCAAATCCACCGTCA
TAAAACCGGTGCGTTGATTCGTGCGGCAGTTCGCCTTGGCGCCCAGGCAGCCGGTGAAGCTGGCCGTAAAACATTATTGT
CACTCGATCGTTACGCCGAGGCCATCGGTTTAGCCTTTCAAGTCCAGGACGATATTTTAGACGTCATTGGCGACACAGCT
ACAATTGGTAAACGTCAAGGATCAGACCAACAACTAGGCAAAAGTACTTATCCGGCGCTACTTGGTCTGGATTGTGCCCA
AACAAAAGCGATGGATCTTTATCAGGAGGCACTAGAGGCCTTGGATGAATTGGCAAAACAGTCCTATAACACGGATTCAT
TGCAGGCATTAGCTCGTTTCATTATTGAGCGTAATAATTAA

Upstream 100 bases:

>100_bases
CAACAAACCCTGTTGCAAGCCGAACAACGGGTACAAATTCTCCTGAGTGACGATGTTGACGCCCCGTTGAAACCTTTTAC
CCCAGATACTGAGTAGCCTT

Downstream 100 bases:

>100_bases
AACGTAATCATTTAAAATAGCCCCAGTGTTATTGCCATTGCAGCTAGGTAGCGAGTAAATCCTGAACAGTGAAAACCGCG
AATAACGCAATAACATCAAG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSDTHAPVDFKQQLAAHQQRVNQALLDFIAPLPFGNSNLIEAMRYGAVIGGKRLRPYLVYATGQMFGLSLANLDAPAAAI
ECIHAYSLIHDDLPAMDDDDLRRGQPTCHVKFGEAHAILAGDALQTLAFSILAEAPMPDVADKDRLSMIIELAQASGAAG
MCAGQALDLEAETRPVLLGDLEQIHRHKTGALIRAAVRLGAQAAGEAGRKTLLSLDRYAEAIGLAFQVQDDILDVIGDTA
TIGKRQGSDQQLGKSTYPALLGLDCAQTKAMDLYQEALEALDELAKQSYNTDSLQALARFIIERNN

Sequences:

>Translated_306_residues
MSDTHAPVDFKQQLAAHQQRVNQALLDFIAPLPFGNSNLIEAMRYGAVIGGKRLRPYLVYATGQMFGLSLANLDAPAAAI
ECIHAYSLIHDDLPAMDDDDLRRGQPTCHVKFGEAHAILAGDALQTLAFSILAEAPMPDVADKDRLSMIIELAQASGAAG
MCAGQALDLEAETRPVLLGDLEQIHRHKTGALIRAAVRLGAQAAGEAGRKTLLSLDRYAEAIGLAFQVQDDILDVIGDTA
TIGKRQGSDQQLGKSTYPALLGLDCAQTKAMDLYQEALEALDELAKQSYNTDSLQALARFIIERNN
>Mature_305_residues
SDTHAPVDFKQQLAAHQQRVNQALLDFIAPLPFGNSNLIEAMRYGAVIGGKRLRPYLVYATGQMFGLSLANLDAPAAAIE
CIHAYSLIHDDLPAMDDDDLRRGQPTCHVKFGEAHAILAGDALQTLAFSILAEAPMPDVADKDRLSMIIELAQASGAAGM
CAGQALDLEAETRPVLLGDLEQIHRHKTGALIRAAVRLGAQAAGEAGRKTLLSLDRYAEAIGLAFQVQDDILDVIGDTAT
IGKRQGSDQQLGKSTYPALLGLDCAQTKAMDLYQEALEALDELAKQSYNTDSLQALARFIIERNN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=299, Percent_Identity=72.2408026755853, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1789578, Length=232, Percent_Identity=30.1724137931034, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17505681, Length=192, Percent_Identity=29.1666666666667, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24651612, Length=223, Percent_Identity=28.2511210762332, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32920; Mature: 32789

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTHAPVDFKQQLAAHQQRVNQALLDFIAPLPFGNSNLIEAMRYGAVIGGKRLRPYLVY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEE
ATGQMFGLSLANLDAPAAAIECIHAYSLIHDDLPAMDDDDLRRGQPTCHVKFGEAHAILA
ECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCEEEEE
GDALQTLAFSILAEAPMPDVADKDRLSMIIELAQASGAAGMCAGQALDLEAETRPVLLGD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHH
LEQIHRHKTGALIRAAVRLGAQAAGEAGRKTLLSLDRYAEAIGLAFQVQDDILDVIGDTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCH
TIGKRQGSDQQLGKSTYPALLGLDCAQTKAMDLYQEALEALDELAKQSYNTDSLQALARF
HHCCCCCCHHHHCCHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IIERNN
HHHCCC
>Mature Secondary Structure 
SDTHAPVDFKQQLAAHQQRVNQALLDFIAPLPFGNSNLIEAMRYGAVIGGKRLRPYLVY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEE
ATGQMFGLSLANLDAPAAAIECIHAYSLIHDDLPAMDDDDLRRGQPTCHVKFGEAHAILA
ECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCEEEEE
GDALQTLAFSILAEAPMPDVADKDRLSMIIELAQASGAAGMCAGQALDLEAETRPVLLGD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHH
LEQIHRHKTGALIRAAVRLGAQAAGEAGRKTLLSLDRYAEAIGLAFQVQDDILDVIGDTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCH
TIGKRQGSDQQLGKSTYPALLGLDCAQTKAMDLYQEALEALDELAKQSYNTDSLQALARF
HHCCCCCCHHHHCCHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IIERNN
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]