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The map label for this gene is cyoE [H]

Identifier: 218930198

GI number: 218930198

Start: 3531536

End: 3532426

Strand: Direct

Name: cyoE [H]

Synonym: YPO3168

Alternate gene names: 218930198

Gene position: 3531536-3532426 (Clockwise)

Preceding gene: 218930197

Following gene: 218930199

Centisome position: 75.89

GC content: 46.58

Gene sequence:

>891_bases
GTGATGATTAAGCAATACCTGCAAGTCACTAAGCCAGGAATTATTTTCGGTAATTTAATTTCTGTCATTGGGGGTTTTCT
CCTCGCTTCCAAGGGCGATATTGATTACCCCCTGTTTCTCTCCACCTTATTAGGTGTCTCGTTAGTTGTTGCCTCCGGGT
GCGTATTTAACAACTATATCGATCGAGATATCGATAAAATCATGGAGAGAACGAAGAATCGTGTCCTGGTCAAAGGGCTT
ATCGATCCGAAGGTATCCCTGATTTATGCATCGGTACTGGGTATTGCTGGCATGCTGTTGCTCTACGTGGCAGCTAATGC
ATTAGCAATGATGCTGGCTGTTATTGGTTTCGTTATCTATGTTGGGGTGTATAGCCTCTACATGAAACGTAAATCAGTCT
ACGGCACCTTGATTGGCAGCTTGTCAGGCGCCGCTCCCCCCGTTATTGGTTACTGTGCCGTAACGGGGCAATTCGACACT
GGCGCACTGATCTTGTTGCTGATCTTCAGTCTGTGGCAAATGCCTCATTCCTATGCCATCGCCATCTTCCGCTTTAAGGA
TTATCAGGCCGCCAACATTCCGGTACTCCCGGTGATAAAAGGGATATCGGTCACCAAAAACCATATTACCCTTTATATTT
TGGCGTTTATGGTCGCAACCTTGATGCTGACATTAAGTGGCTATGCCGGTTATAAATATCTGGTTGTGGCTGCCGCGGTT
AGCGTCTGGTGGCTGGGTATGGCACTGCGCGGTTATAAGGCAACGAATGACAGCGTATGGGCGAGAAAACTCTTTGTCTT
CTCTATCATTGCCATTACGTCATTGAGCGTCATGATGTCAGTTGATTTCAATGTACACTCTTCGGCAGTACTCCTGACTT
ACGCTGGATAG

Upstream 100 bases:

>100_bases
CTCCTGTTCACCGCTATGATTATTGCAATCGTTGTAGTGGGCTCACTCTGGATTATGTACAACCTCAACATCAATATGAT
GGTTGACTGAAGAGCTGCAT

Downstream 100 bases:

>100_bases
TCTTAGCGAAAATGATGAGAGTGAAATAAATCAAGTGGCTGGCAGGAATCGCTCTTGCCAGCCACTTTGTATTTGTTCCC
TGTTTTGTATTTGTACCCAG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRVLVKGL
IDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDT
GALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAV
SVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG

Sequences:

>Translated_296_residues
MMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRVLVKGL
IDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDT
GALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAV
SVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
>Mature_296_residues
MMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRVLVKGL
IDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDT
GALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAV
SVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=35.1190476190476, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786631, Length=292, Percent_Identity=84.2465753424658, Blast_Score=493, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71998235, Length=229, Percent_Identity=28.82096069869, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=193, Percent_Identity=28.4974093264249, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19921064, Length=273, Percent_Identity=28.9377289377289, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32179; Mature: 32179

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYI
CCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
DRDIDKIMERTKNRVLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIY
HHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTGALILLLIFSLWQMPHSYAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHEE
AIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAV
EEEEEECCCCCCCCHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECC
>Mature Secondary Structure
MMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYI
CCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
DRDIDKIMERTKNRVLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIY
HHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTGALILLLIFSLWQMPHSYAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHEE
AIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAV
EEEEEECCCCCCCCHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA