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The map label for this gene is hemF [H]

Identifier: 218930077

GI number: 218930077

Start: 3385073

End: 3386002

Strand: Direct

Name: hemF [H]

Synonym: YPO3032

Alternate gene names: 218930077

Gene position: 3385073-3386002 (Clockwise)

Preceding gene: 218930075

Following gene: 218930078

Centisome position: 72.74

GC content: 53.33

Gene sequence:

>930_bases
ATGAACTCACCCGATATAGCCCTAATCAAAACCTACCTGCTCACTTTGCAGGATAACATCTGTGCGGCCCTGGCTCAGGC
CGATGGCCACGCCGAATTCACGGAAGAGTGCTGGGTCCGCGAAGAAGGTGGCGGTGGCCGCAGCCGGGTCTTGGTTAATG
GCGCTGTATTCGAACAAGCTGGGGTTAACTTCTCCCATGTGTCCGGGGCGATGTTACCCGCCTCTGCCACTGCTCACCGG
CCAGAGTTGGCGGGCCGCAGTTTTCAGGCGCTGGGCGTATCGCTGGTTATTCATCCGCTAAATCCTTATCTGCCTACCAG
CCACGCCAATGTGCGGTTCTTTATTGCTGAGAAACCCGGTGAAGACGCCGTGTGGTGGTTTGGCGGTGGTTTTGATTTAA
CCCCGTACTACGGCTTTGAAGAAGATGCCATTCATTGGCATCAGGTAGCGCATAGCCTTTGCCAGCCATTCGGCGAGCAA
ATCTATCCGCGCTATAAAAAATGGTGTGATGACTATTTTTATATTAAACATCGCCAGGAAGCCCGTGGTATTGGCGGCCT
GTTTTTTGACGATCTGAATAGTCCTGATTTTATGACCTGCTTTAATTTCACCCAAGCCGTTGGCGATGGCTTCCTGGCGG
CTTATATGCCAATCGTCGCGCGGCGTAAAGCGCTGGGCTGGGGTGATCGAGAGCGTCAATTCCAGCTTTATCGCCGGGGC
CGCTATGTCGAGTTCAATCTGGTCTGGGATCGCGGTACGTTGTTCGGCCTGCAAACGGGTGGGCGCACTGAATCTATTTT
GATGTCCCTGCCGCCGTTGGTGCGCTGGGAATATAACTATCAGCCAGAGGCAGATAGTGCAGAAGCCGCGTTGTACCGCG
ATTTTCTGCCGGTAAAAGACTGGTTAGCAATTAAAGGAGAAACACACTAA

Upstream 100 bases:

>100_bases
TAAAAGTAAGCTGCCGCGCGGATCCATACTGACAGTACAAAAATAGAGGGAAATTGGGGTATACTTAGCGCCTGAAAATT
TCCACCAGTGAACCCCTCTG

Downstream 100 bases:

>100_bases
TGCAGATTTGGGTCGATGCGGACGCCTGTCCCAATGTGATTAAAGAGGTCTTATTTCGCGCCGCTGATCGTACCGGCATG
ATGGTGACATTGGTCGCTAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHR
PELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQ
IYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH

Sequences:

>Translated_309_residues
MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHR
PELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQ
IYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH
>Mature_309_residues
MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHR
PELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQ
IYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=46.6887417218543, Blast_Score=274, Evalue=6e-74,
Organism=Escherichia coli, GI1788777, Length=300, Percent_Identity=75.3333333333333, Blast_Score=479, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=42.5, Blast_Score=251, Evalue=9e-68,
Organism=Drosophila melanogaster, GI17864388, Length=302, Percent_Identity=49.0066225165563, Blast_Score=290, Evalue=7e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35005; Mature: 35005

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCEEEEEECEEHHHC
GVNFSHVSGAMLPASATAHRPELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPG
CCCHHHCCCCCCCCCCCCCCCHHCCCCHHEEEEEEEEECCCCCCCCCCCCEEEEEEECCC
EDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQIYPRYKKWCDDYFYIKHRQE
CCEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
ARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
CCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKD
CEEEEEEEECCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCH
WLAIKGETH
HEEECCCCC
>Mature Secondary Structure
MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCEEEEEECEEHHHC
GVNFSHVSGAMLPASATAHRPELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPG
CCCHHHCCCCCCCCCCCCCCCHHCCCCHHEEEEEEEEECCCCCCCCCCCCEEEEEEECCC
EDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQIYPRYKKWCDDYFYIKHRQE
CCEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
ARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
CCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKD
CEEEEEEEECCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCH
WLAIKGETH
HEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA