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The map label for this gene is murQ

Identifier: 218929980

GI number: 218929980

Start: 3270680

End: 3271567

Strand: Reverse

Name: murQ

Synonym: YPO2925

Alternate gene names: 218929980

Gene position: 3271567-3270680 (Counterclockwise)

Preceding gene: 218929983

Following gene: 218929979

Centisome position: 70.3

GC content: 53.49

Gene sequence:

>888_bases
ATGAGTCTGGGAGCATTAATTTCTGAAAGCCGTAATCCGGCAACCATGGAATTAGATAAACTCTCTACGTTGGCGATGCT
GACCTGTATCAATGACGAGGACCGTAAAGTACCAGATGCGATTCGTTTGGTCTTACCGGCGGTTGCTCAAGCGGTGGATT
TAGCTGCTGATGCATTAAAGCAGGGCGGGCGGTTGATCTACTTAGGCGCTGGAACCAGTGGTCGACTCGGTGTGTTGGAT
GCTTCTGAATGCCCGCCGACCTTCGGGGTTCCCCATGGTATGGTTATTGGCCTGATTGCTGGTGGCCCAGGGGCTTTGCT
CAAAGCGGTGGAAGGCGCTGAAGATGATATAGCTCTGGGGATGCGGGACCTGCAAGATTTGCAACTCACTGCCACCGATA
TGGTGGTCGGGCTGGCCGCATCTGGCCGCACGCCTTATGTGATTGGTGCGTTACGTTATGCCCGTGAGTTGGGGTGCCCA
ACGGCCGCCATTTCTTGCAATCCAGATTCCCCTATCGCGCAGGAAGCGCAGGTTGCGATTTCACCGGTGGTAGGGCCTGA
GGCATTGACCGGTTCGACCCGGATGAAATCAGGGACTGCACAGAAACTGGTGCTGAATATGTTATCCACCGGGGCTATGG
TTAAACTGGGTAAGGTCTATCAAAATTTGATGGTTGATGTGAAGGCAACCAATGTGAAGTTAGTTGACCGTGCCTGCCGT
ATTGTTGTCGAGGCCACGGGCGTCAGCCGGGCAGAGGCTGAACACGCGTTGAGACAAACAGATTTTGAGGTCAAACCCGC
CATTCTGATGCTCTTGAAAGGGGTGAGTGCTGAGCAGGCGCGTCAGGATTTACGGCAACATCATGGCTATTTACGCGCAG
CTCTATAA

Upstream 100 bases:

>100_bases
AGTTGCGAGCGAAAGGGGGAGTAAAGTGTTTGTTTTAATGAATATTACATTCAATCATAACTAGATAACGATGAATTAAA
AATTCAATAAGGAGTGGGCT

Downstream 100 bases:

>100_bases
AGGCTCACATTCAAGACATTGGCAATGGATAAATTAGCCGTATTCAAAATGCGTAACACCCATTATTGAATCATGAAGCT
AGTGATCAGTATATTCATTC

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSLGALISESRNPATMELDKLSTLAMLTCINDEDRKVPDAIRLVLPAVAQAVDLAADALKQGGRLIYLGAGTSGRLGVLD
ASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDIALGMRDLQDLQLTATDMVVGLAASGRTPYVIGALRYARELGCP
TAAISCNPDSPIAQEAQVAISPVVGPEALTGSTRMKSGTAQKLVLNMLSTGAMVKLGKVYQNLMVDVKATNVKLVDRACR
IVVEATGVSRAEAEHALRQTDFEVKPAILMLLKGVSAEQARQDLRQHHGYLRAAL

Sequences:

>Translated_295_residues
MSLGALISESRNPATMELDKLSTLAMLTCINDEDRKVPDAIRLVLPAVAQAVDLAADALKQGGRLIYLGAGTSGRLGVLD
ASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDIALGMRDLQDLQLTATDMVVGLAASGRTPYVIGALRYARELGCP
TAAISCNPDSPIAQEAQVAISPVVGPEALTGSTRMKSGTAQKLVLNMLSTGAMVKLGKVYQNLMVDVKATNVKLVDRACR
IVVEATGVSRAEAEHALRQTDFEVKPAILMLLKGVSAEQARQDLRQHHGYLRAAL
>Mature_294_residues
SLGALISESRNPATMELDKLSTLAMLTCINDEDRKVPDAIRLVLPAVAQAVDLAADALKQGGRLIYLGAGTSGRLGVLDA
SECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDIALGMRDLQDLQLTATDMVVGLAASGRTPYVIGALRYARELGCPT
AAISCNPDSPIAQEAQVAISPVVGPEALTGSTRMKSGTAQKLVLNMLSTGAMVKLGKVYQNLMVDVKATNVKLVDRACRI
VVEATGVSRAEAEHALRQTDFEVKPAILMLLKGVSAEQARQDLRQHHGYLRAAL

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=295, Percent_Identity=57.6271186440678, Blast_Score=333, Evalue=7e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_YERP3 (A7FFU6)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400124.1
- ProteinModelPortal:   A7FFU6
- SMR:   A7FFU6
- STRING:   A7FFU6
- GeneID:   5384445
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1143
- eggNOG:   COG2103
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- ProtClustDB:   PRK05441
- BioCyc:   YPSE349747:YPSIP31758_1143-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 30902; Mature: 30771

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 83-83 ACT_SITE 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGALISESRNPATMELDKLSTLAMLTCINDEDRKVPDAIRLVLPAVAQAVDLAADALK
CCCCCHHHCCCCCCEEEHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QGGRLIYLGAGTSGRLGVLDASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDIALG
HCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCHHHHH
MRDLQDLQLTATDMVVGLAASGRTPYVIGALRYARELGCPTAAISCNPDSPIAQEAQVAI
HHHHHHHHEEHHHHHEEEECCCCCCEEHHHHHHHHHHCCCEEEEECCCCCCCCHHHHEEE
SPVVGPEALTGSTRMKSGTAQKLVLNMLSTGAMVKLGKVYQNLMVDVKATNVKLVDRACR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCHHHHHHHH
IVVEATGVSRAEAEHALRQTDFEVKPAILMLLKGVSAEQARQDLRQHHGYLRAAL
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
SLGALISESRNPATMELDKLSTLAMLTCINDEDRKVPDAIRLVLPAVAQAVDLAADALK
CCCCHHHCCCCCCEEEHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QGGRLIYLGAGTSGRLGVLDASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDIALG
HCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCHHHHH
MRDLQDLQLTATDMVVGLAASGRTPYVIGALRYARELGCPTAAISCNPDSPIAQEAQVAI
HHHHHHHHEEHHHHHEEEECCCCCCEEHHHHHHHHHHCCCEEEEECCCCCCCCHHHHEEE
SPVVGPEALTGSTRMKSGTAQKLVLNMLSTGAMVKLGKVYQNLMVDVKATNVKLVDRACR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCHHHHHHHH
IVVEATGVSRAEAEHALRQTDFEVKPAILMLLKGVSAEQARQDLRQHHGYLRAAL
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA