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The map label for this gene is pepB [H]

Identifier: 218929948

GI number: 218929948

Start: 3233101

End: 3234399

Strand: Reverse

Name: pepB [H]

Synonym: YPO2889

Alternate gene names: 218929948

Gene position: 3234399-3233101 (Counterclockwise)

Preceding gene: 218929949

Following gene: 218929947

Centisome position: 69.5

GC content: 53.5

Gene sequence:

>1299_bases
ATGACAACAGAAATAATGCAAATATCCCTGTCTCACAACCCGGCAGATGCCCGCTGGGGTGAGAAAGCCCTGATCAGCAC
TAATGATCAAGGGGTGACTATCCACTTGACGAGTCACGATCAACTGGGGGGGATCCAACGTGCAGCCCGCAAAATTGACG
GTCAGGGCATTAAACAAGTCAAACTGGCTGGTGAAGGCTGGGGCCTGGAACAAAGCTGGGCCTTTTGGCAAGGCTTCCGT
GGGCCAAAAGGTCAGCGCAGCGTGGTGTGGGCAGAGCTGCCAGCGAATGAAAAAACAGAGCTGGAACAGCGTTTAAAAAT
CATCGATTGGGTACGCGATACCATCAACGCACCTGCGGAAGATTTAGGGCCAGAACAACTGGCGAAAAATGCGATTGATT
TGCTGTGTGCGGTCTCCTGTGATGCGGTCAGCTACCGTATTACCAAAGGCGAAGATCTCCGTGAACAGAACTATGCCGGG
ATTTACACCGTGGGCCGTGGTTCTGATCGTGCGCCGGTATTGTTGGCGTTGGACTACAACCCAACCGGCAACCCAGATGC
GCCAGTCATGGCCTGTCTGGTGGGGAAAGGCATTACCTTTGATTCCGGCGGCTATAGCTTAAAGCAGAGCGCCTTTATGG
ATTCGATGAAGTCCGATATGGGCGGTGCGGCAACCTTGACCGGTGCATTGGCGTTGGCAGCCGCACGTGGGCTGAAAGAG
CGCGTGAAGTTGTATCTGTGTTGTGCCGATAACATGGTCAGTGGCAATGCCTTTAAGCTGGGCGATATTATTCGCTATCG
TAATGGCAAAACGGTCGAAATCATGAATACCGATGCTGAAGGGCGCTTGGTCTTGGCGGATGGTCTGATCGATGCCTCCG
AGCAAAATGCGCCGTTGATTATCGACGCAGCCACCTTAACCGGCGCGGCCAAAACTGCCTTGGGTAACGATTACCATGCC
CTGTTCAGCTTTGATGATGAACTGGCACAAGCGCTACTCAACAGTGCGCACAGTGAGCACGAGCTTTTCTGGCGTCTGCC
ACTGGCCGAATTCCATCGCAGCCAGTTGCCATCTAACTTTGCTGAGTTAAATAACGTGGCCGGTGGGGCCTACAGCGCAG
GGGCCAGCACCGCCGCCGCTTTCCTGTCGCATTTTGTGAAAAATTATCAGCAGGGCTGGTTACACATTGATTGCTCGGCG
ACATATCGCAAAAGCGCCGTTGATCAATGGTCTGCCGGAGCGACTGGCTTGGGTGTCCGCACCGTTGCCAACTTATTGTT
AGCGCAAGCAAAACAGTAA

Upstream 100 bases:

>100_bases
ATCTAATATTTTATGCCCAAATTATTGACGTCGCCGCTCACGCCCCTGTGGCTTGAAGCATGACGGGTATACAGCAAAAA
TAATAATGACGAGGTAGGCC

Downstream 100 bases:

>100_bases
TCTTATTGAATTGAGAAGACTCAAAGGGGCGCATTTGGCGTCCCTTCGTTCATCTTCTCGATGTTTTGGGAGTAAAAAAT
GAGTTTTCCGCCCCCATCTA

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQVKLAGEGWGLEQSWAFWQGFR
GPKGQRSVVWAELPANEKTELEQRLKIIDWVRDTINAPAEDLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAG
IYTVGRGSDRAPVLLALDYNPTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLIIDAATLTGAAKTALGNDYHA
LFSFDDELAQALLNSAHSEHELFWRLPLAEFHRSQLPSNFAELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSA
TYRKSAVDQWSAGATGLGVRTVANLLLAQAKQ

Sequences:

>Translated_432_residues
MTTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQVKLAGEGWGLEQSWAFWQGFR
GPKGQRSVVWAELPANEKTELEQRLKIIDWVRDTINAPAEDLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAG
IYTVGRGSDRAPVLLALDYNPTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLIIDAATLTGAAKTALGNDYHA
LFSFDDELAQALLNSAHSEHELFWRLPLAEFHRSQLPSNFAELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSA
TYRKSAVDQWSAGATGLGVRTVANLLLAQAKQ
>Mature_431_residues
TTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQVKLAGEGWGLEQSWAFWQGFRG
PKGQRSVVWAELPANEKTELEQRLKIIDWVRDTINAPAEDLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAGI
YTVGRGSDRAPVLLALDYNPTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKER
VKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLIIDAATLTGAAKTALGNDYHAL
FSFDDELAQALLNSAHSEHELFWRLPLAEFHRSQLPSNFAELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSAT
YRKSAVDQWSAGATGLGVRTVANLLLAQAKQ

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=318, Percent_Identity=38.6792452830189, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI47155554, Length=276, Percent_Identity=36.5942028985507, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI87082123, Length=426, Percent_Identity=75.8215962441315, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI1790710, Length=319, Percent_Identity=37.3040752351097, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=299, Percent_Identity=33.7792642140468, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=121, Percent_Identity=38.0165289256198, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221379063, Length=341, Percent_Identity=32.8445747800587, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI221379062, Length=341, Percent_Identity=32.8445747800587, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21357381, Length=341, Percent_Identity=32.8445747800587, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21355725, Length=362, Percent_Identity=27.9005524861878, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24661038, Length=386, Percent_Identity=27.2020725388601, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24662227, Length=325, Percent_Identity=29.2307692307692, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129969, Length=292, Percent_Identity=30.4794520547945, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077148, Length=325, Percent_Identity=29.5384615384615, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20130057, Length=325, Percent_Identity=29.5384615384615, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355645, Length=322, Percent_Identity=27.9503105590062, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24662223, Length=322, Percent_Identity=27.9503105590062, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922386, Length=291, Percent_Identity=28.8659793814433, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20129963, Length=288, Percent_Identity=30.2083333333333, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646701, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646703, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358201, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 46531; Mature: 46400

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQV
CCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEE
KLAGEGWGLEQSWAFWQGFRGPKGQRSVVWAELPANEKTELEQRLKIIDWVRDTINAPAE
EEECCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
DLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAGIYTVGRGSDRAPVLLALDYN
HCCHHHHHHHHHHHHHHEECCCEEEEECCCCCHHHCCCCEEEEECCCCCCCCEEEEEECC
PTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
CCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHH
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLI
HEEEEEEECCCCCCCCCEEHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEE
IDAATLTGAAKTALGNDYHALFSFDDELAQALLNSAHSEHELFWRLPLAEFHRSQLPSNF
EEEHHHCCHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCHHH
AELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSATYRKSAVDQWSAGATGLGVR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCCHHH
TVANLLLAQAKQ
HHHHHHHHHCCC
>Mature Secondary Structure 
TTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQV
CCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEE
KLAGEGWGLEQSWAFWQGFRGPKGQRSVVWAELPANEKTELEQRLKIIDWVRDTINAPAE
EEECCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
DLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAGIYTVGRGSDRAPVLLALDYN
HCCHHHHHHHHHHHHHHEECCCEEEEECCCCCHHHCCCCEEEEECCCCCCCCEEEEEECC
PTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
CCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHH
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLI
HEEEEEEECCCCCCCCCEEHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEE
IDAATLTGAAKTALGNDYHALFSFDDELAQALLNSAHSEHELFWRLPLAEFHRSQLPSNF
EEEHHHCCHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCHHH
AELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSATYRKSAVDQWSAGATGLGVR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCCHHH
TVANLLLAQAKQ
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA