Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 218929900

GI number: 218929900

Start: 3166073

End: 3167632

Strand: Direct

Name: ppx [H]

Synonym: YPO2837

Alternate gene names: 218929900

Gene position: 3166073-3167632 (Clockwise)

Preceding gene: 218929899

Following gene: 218929901

Centisome position: 68.03

GC content: 51.03

Gene sequence:

>1560_bases
ATGCCGCTAACCAATAATTCGACTACCAAACCGCAGGAAATCGCCGCCATCGATCTTGGCTCTAACAGTTTCCATATGGT
CATTGCCCGTGTCGTCAACGGCGCTTTGCAAGTTTTAGGGCGCCTGAAACAACGCGTGCATCTGGCCGATGGCCTGGATA
GCAATAATATGCTCAGTGAGGAGGCTATCGAGCGCGGCCTGGCCTGTCTGGCCCTGTTTGCTGAACGTTTGCAGGGGTTC
TCCCCAGATAACGTGTGTATCGTCGGGACTCACACCCTGCGGCAAGCCGCCAATGCAGAGACATTCCTCAAACGTGCCGC
CGAGGTTATCCCTTATCCCATTGAAATTATCTCGGGCCAGGAAGAGGCGCGCCTGATTTTTATGGGCGTTGAGCACACCC
AACCAGAGAAGGGCCGCAAGCTGGTGATCGACATCGGTGGCGGATCGACAGAAATGGTGATTGGCGAGGACTTTGAGCCA
TTGCTGGTAGAGAGCCGCCGTATGGGCTGCGTCAGTTTTGCTCAACAGTTTTTCCCTGGTGGTGAAATCAGCAAGAATAA
TTTCAGACGTGCGCGTCTGGCCGCGGCACAAAAGTTGGAAAATCTGGCATGGCAATACCGGATCCAAGGCTGGCAATATG
CGCTGGGTGCGTCTGGCACCATTAAAGCCACCTATGAAGTCTTGGTCGAAATGGGCGAAAAAGACGGTTTGATCACGCCT
GAACGGCTGGAGATGCTGGTTGAAAATGTCCTGCAATTCAAGCAATTCTCAGCCCTGAGTCTGCCGGGGCTTTCGGAGGA
TCGCCAATCCGTATTTGTTCCAGGGCTGGCTATTCTCTGTGGCGTATTCGACGCATTGGCCATCAAAACATTACGTTTAT
CTGACGGTGCGCTACGTGAAGGTGTGCTGTATGAAATGGAAGGTCGCTTCCGCCATCAGGATATCCGTCAACGTACCGCC
AAAAGTTTGGCAGATCACTACAATATTGATCGTGAACAAGCCCGTCGGGTGCTGGAAACCACGGAGCAACTGTATACCCA
ATGGTTGGCACAAAATACCAAGCTGGTACAGCCCCAACTGGAAGCATTATTGAAATGGGCGGCGATGCTGCATGAAGTTG
GCCTGAGCATTAATCACAGCGGCATGCATCGTCATTCGGCCTATATTTTACAAAATACGAATTTACCGGGCTTCAATCAG
GAGCAACAAACCCTGTTGGCGACGTTGGTCCGAATGCACCGTAAAGCCATCAAATTGGATGAATTGCCACGCCTGAATTT
ATTCAAGAAGAAATACTATTTGCCGTTAATTCAATTATTGCGTCTGAGCACATTGCTGAATAATCAACGCCAATCCACCA
CCACACCAGAAAGCCTGCGGTTGATAACCGACGACAGTCACTGGACATTGCGTTTTCCACATGGCTATTTGACGCAAAAC
AGTCTGGTGCAACTGGATTTCGAACGCGAACAGGCCTACTGGGATGATGTTGTGGGCTGGAAGCTGGTTATTGAAGAAGA
AGAGCCGGATGAGGCTGCAAAAGTGGCCCCTGAAGAGTGA

Upstream 100 bases:

>100_bases
CGTTATGTACCGCGTGGAAACCGGCGCAAAGTACGTGCACAGATTGCTATCTATGATTATTTAAAAGCACTGGAACAACC
GGAGCAGTAGACCTAACACT

Downstream 100 bases:

>100_bases
TCTGACGCTAATAAAATCGTGCACCGGGTGGTTGTCATCACCCGGTGCGTCAATTGACAGCATGAGCGGTTAAATCATTC
GTCGTTAAAACGATCAATCG

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MPLTNNSTTKPQEIAAIDLGSNSFHMVIARVVNGALQVLGRLKQRVHLADGLDSNNMLSEEAIERGLACLALFAERLQGF
SPDNVCIVGTHTLRQAANAETFLKRAAEVIPYPIEIISGQEEARLIFMGVEHTQPEKGRKLVIDIGGGSTEMVIGEDFEP
LLVESRRMGCVSFAQQFFPGGEISKNNFRRARLAAAQKLENLAWQYRIQGWQYALGASGTIKATYEVLVEMGEKDGLITP
ERLEMLVENVLQFKQFSALSLPGLSEDRQSVFVPGLAILCGVFDALAIKTLRLSDGALREGVLYEMEGRFRHQDIRQRTA
KSLADHYNIDREQARRVLETTEQLYTQWLAQNTKLVQPQLEALLKWAAMLHEVGLSINHSGMHRHSAYILQNTNLPGFNQ
EQQTLLATLVRMHRKAIKLDELPRLNLFKKKYYLPLIQLLRLSTLLNNQRQSTTTPESLRLITDDSHWTLRFPHGYLTQN
SLVQLDFEREQAYWDDVVGWKLVIEEEEPDEAAKVAPEE

Sequences:

>Translated_519_residues
MPLTNNSTTKPQEIAAIDLGSNSFHMVIARVVNGALQVLGRLKQRVHLADGLDSNNMLSEEAIERGLACLALFAERLQGF
SPDNVCIVGTHTLRQAANAETFLKRAAEVIPYPIEIISGQEEARLIFMGVEHTQPEKGRKLVIDIGGGSTEMVIGEDFEP
LLVESRRMGCVSFAQQFFPGGEISKNNFRRARLAAAQKLENLAWQYRIQGWQYALGASGTIKATYEVLVEMGEKDGLITP
ERLEMLVENVLQFKQFSALSLPGLSEDRQSVFVPGLAILCGVFDALAIKTLRLSDGALREGVLYEMEGRFRHQDIRQRTA
KSLADHYNIDREQARRVLETTEQLYTQWLAQNTKLVQPQLEALLKWAAMLHEVGLSINHSGMHRHSAYILQNTNLPGFNQ
EQQTLLATLVRMHRKAIKLDELPRLNLFKKKYYLPLIQLLRLSTLLNNQRQSTTTPESLRLITDDSHWTLRFPHGYLTQN
SLVQLDFEREQAYWDDVVGWKLVIEEEEPDEAAKVAPEE
>Mature_518_residues
PLTNNSTTKPQEIAAIDLGSNSFHMVIARVVNGALQVLGRLKQRVHLADGLDSNNMLSEEAIERGLACLALFAERLQGFS
PDNVCIVGTHTLRQAANAETFLKRAAEVIPYPIEIISGQEEARLIFMGVEHTQPEKGRKLVIDIGGGSTEMVIGEDFEPL
LVESRRMGCVSFAQQFFPGGEISKNNFRRARLAAAQKLENLAWQYRIQGWQYALGASGTIKATYEVLVEMGEKDGLITPE
RLEMLVENVLQFKQFSALSLPGLSEDRQSVFVPGLAILCGVFDALAIKTLRLSDGALREGVLYEMEGRFRHQDIRQRTAK
SLADHYNIDREQARRVLETTEQLYTQWLAQNTKLVQPQLEALLKWAAMLHEVGLSINHSGMHRHSAYILQNTNLPGFNQE
QQTLLATLVRMHRKAIKLDELPRLNLFKKKYYLPLIQLLRLSTLLNNQRQSTTTPESLRLITDDSHWTLRFPHGYLTQNS
LVQLDFEREQAYWDDVVGWKLVIEEEEPDEAAKVAPEE

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=513, Percent_Identity=77.1929824561403, Blast_Score=814, Evalue=0.0,
Organism=Escherichia coli, GI48994966, Length=488, Percent_Identity=39.5491803278689, Blast_Score=338, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 58712; Mature: 58581

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTNNSTTKPQEIAAIDLGSNSFHMVIARVVNGALQVLGRLKQRVHLADGLDSNNMLSE
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EAIERGLACLALFAERLQGFSPDNVCIVGTHTLRQAANAETFLKRAAEVIPYPIEIISGQ
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHCCCCCEEECCC
EEARLIFMGVEHTQPEKGRKLVIDIGGGSTEMVIGEDFEPLLVESRRMGCVSFAQQFFPG
CCCEEEEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHCCC
GEISKNNFRRARLAAAQKLENLAWQYRIQGWQYALGASGTIKATYEVLVEMGEKDGLITP
CCCCCCHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCHHHHHHHHHHHCCCCCCCCH
ERLEMLVENVLQFKQFSALSLPGLSEDRQSVFVPGLAILCGVFDALAIKTLRLSDGALRE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHEECCCCCHHC
GVLYEMEGRFRHQDIRQRTAKSLADHYNIDREQARRVLETTEQLYTQWLAQNTKLVQPQL
CCEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
EALLKWAAMLHEVGLSINHSGMHRHSAYILQNTNLPGFNQEQQTLLATLVRMHRKAIKLD
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
ELPRLNLFKKKYYLPLIQLLRLSTLLNNQRQSTTTPESLRLITDDSHWTLRFPHGYLTQN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCC
SLVQLDFEREQAYWDDVVGWKLVIEEEEPDEAAKVAPEE
CEEEEEEHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCC
>Mature Secondary Structure 
PLTNNSTTKPQEIAAIDLGSNSFHMVIARVVNGALQVLGRLKQRVHLADGLDSNNMLSE
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EAIERGLACLALFAERLQGFSPDNVCIVGTHTLRQAANAETFLKRAAEVIPYPIEIISGQ
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHCCCCCEEECCC
EEARLIFMGVEHTQPEKGRKLVIDIGGGSTEMVIGEDFEPLLVESRRMGCVSFAQQFFPG
CCCEEEEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHCCC
GEISKNNFRRARLAAAQKLENLAWQYRIQGWQYALGASGTIKATYEVLVEMGEKDGLITP
CCCCCCHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCHHHHHHHHHHHCCCCCCCCH
ERLEMLVENVLQFKQFSALSLPGLSEDRQSVFVPGLAILCGVFDALAIKTLRLSDGALRE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHEECCCCCHHC
GVLYEMEGRFRHQDIRQRTAKSLADHYNIDREQARRVLETTEQLYTQWLAQNTKLVQPQL
CCEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
EALLKWAAMLHEVGLSINHSGMHRHSAYILQNTNLPGFNQEQQTLLATLVRMHRKAIKLD
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
ELPRLNLFKKKYYLPLIQLLRLSTLLNNQRQSTTTPESLRLITDDSHWTLRFPHGYLTQN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCC
SLVQLDFEREQAYWDDVVGWKLVIEEEEPDEAAKVAPEE
CEEEEEEHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]