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The map label for this gene is ung [H]

Identifier: 218929776

GI number: 218929776

Start: 3031513

End: 3032199

Strand: Reverse

Name: ung [H]

Synonym: YPO2704

Alternate gene names: 218929776

Gene position: 3032199-3031513 (Counterclockwise)

Preceding gene: 218929780

Following gene: 218929765

Centisome position: 65.16

GC content: 46.72

Gene sequence:

>687_bases
ATGTCCCCCTCCCTTACTTGGCACGATGTAATCGGCCAAGAAAAAGAACAACCGTATTTTAAAGATACGCTGGCCTATGT
GGCAGCAGAACGCCGTGCGGGTAAGACCATCTATCCACCACAAAAAGATATATTTAACGCTTTTCGCCTGACCGAACTGG
ATCAAGTAAAAGTCGTCATTCTGGGGCAAGATCCGTATCACGGCCCCAACCAGGCTCATGGATTATCATTTTCGGTTCTA
CCTGGTGTTCCTGCCCCCCCTTCATTGGGGAATATATACAAGGAACTGGTCACTGATATTCCAGGATTCCAGCGCCCTAA
CCACGGTTTTTTACAAAGCTGGGCCGAGCAAGGCGTTTTATTACTTAATACGGTCCTGACGGTAGAAGCGGGCAAAGCCC
ACTCTCATGCTAACCTTGGTTGGGAAACCTTTACGGATAAAGTGATTGCTGCGTTGAATGAACACCGAGAAGGTGTGATT
TTTATGTTGTGGGGATCACATGCTCAGAAAAAAGGCCGCATTATTAATACTGAGCGCCATTATATTTTGAAAGCACCTCA
TCCATCACCCTTGTCAGCACACCGTGGTTTTCTGGGCTGTAAGCACTTTTCGCAAGCTAATCAATTACTGCAACAACAAA
ATCAGCAGCCTATTGATTGGCAACCTAAGCTGCCAGCGGTGGAGTAA

Upstream 100 bases:

>100_bases
CAACATCATGTCACAGACATCGGTTTAACAGTTTCACTCATCGGTTTGAACCGGTAAGCTAGCGCACATCAATACTTTGC
AGAAACCAAGGAGAGTGTTT

Downstream 100 bases:

>100_bases
ATCACCGTTCAGATCACAACCCCACCTCTTAAGCCAGGACGTTGTCTGTAACCTCACGCCACCTTCGGCTGCCGTGAGGT
TATTGGAAGATCAGTGAACT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVILGQDPYHGPNQAHGLSFSVL
PGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAALNEHREGVI
FMLWGSHAQKKGRIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE

Sequences:

>Translated_228_residues
MSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVILGQDPYHGPNQAHGLSFSVL
PGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAALNEHREGVI
FMLWGSHAQKKGRIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE
>Mature_227_residues
SPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVILGQDPYHGPNQAHGLSFSVLP
GVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAALNEHREGVIF
MLWGSHAQKKGRIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=55.5555555555556, Blast_Score=254, Evalue=4e-68,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=55.5555555555556, Blast_Score=254, Evalue=5e-68,
Organism=Escherichia coli, GI1788934, Length=226, Percent_Identity=73.0088495575221, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=48.6111111111111, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323620, Length=232, Percent_Identity=46.551724137931, Blast_Score=193, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25559; Mature: 25428

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVI
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEE
LGQDPYHGPNQAHGLSFSVLPGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVL
EECCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEE
LLNTVLTVEAGKAHSHANLGWETFTDKVIAALNEHREGVIFMLWGSHAQKKGRIINTERH
EEHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCE
YILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVI
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEE
LGQDPYHGPNQAHGLSFSVLPGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVL
EECCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEE
LLNTVLTVEAGKAHSHANLGWETFTDKVIAALNEHREGVIFMLWGSHAQKKGRIINTERH
EEHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCE
YILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA