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The map label for this gene is cycA [H]

Identifier: 218928978

GI number: 218928978

Start: 2106730

End: 2108154

Strand: Reverse

Name: cycA [H]

Synonym: YPO1859

Alternate gene names: 218928978

Gene position: 2108154-2106730 (Counterclockwise)

Preceding gene: 218928980

Following gene: 218928976

Centisome position: 45.3

GC content: 46.6

Gene sequence:

>1425_bases
ATGGGAAAGATGGTAGACCAATCCAAAATAGTGGCAGAGCCGTTACAAGAACCTGAAGAACACCTCCAACGAAGCCTCTC
CAATCGGCATATCCAACTCATCGCCATTGGCGGTGCCATAGGTACCGGGTTGTTTATGGGATCGGGCAAAACCATCAGCC
TTGCCGGGCCGTCGATCATTTTCGTCTATATGATCATTGGTTTTATGTTGTTTTTCGTGATGCGGGCAATGGGTGAACTG
TTGCTATCGAATCTGAACTATAAATCATTCAGTGATTTCTCCGCTGACTTACTTGGCCCTTGGGCTGGTTTTTTCACCGG
TTGGACTTACTGGTTTTGTTGGGTCATCACCGGTATTGCTGATGTAGTGGCCATCACCGCTTATGCACAGTTCTGGTTCC
CTGATTTCTCTCAATGGGTTGCCTCGCTATTAGTCGTTTTACTGTTGTTGTCACTGAACTTGGCCACAGTAAAAATGTTT
GGTGAGATGGAGTTCTGGTTTGCCATGATTAAAATCGTGGCTATCGTGGCGCTAATTTTTGCTGGCCTAACCATGGTCTT
AGTCAGCTATCAGTCACCATCTGGTACCACCGCTTCATTTACGCATTTATGGAGTGACGGAGGTATGTTCCCGAAAGGGA
TCAGTGGATTCTTTGCTGGCTTCCAAATTGCCGTTTTTGCCTTTGTAGGTATTGAACTGGTTGGGACCACAGCGGCAGAA
ACCAAAGACCCAGAGGTGGTTTTACCACGAGCCATTAACTCCATTCCGATTCGCATAATCATGTTTTATGTTTTCTCATT
AATTATGATTATGTCGGTAACGCCGTGGAGTTCAGTCGTCGCGGATAAAAGCCCGTTTGTTGAGTTATTCGTCTTGGTCG
GGCTGCCCGCAGCGGCCAGTGTCATTAACTTTGTGGTATTAACCTCTGCGGCCTCCTCGGCCAACAGTGGCGTGTTCTCC
ACCAGCAGGATGTTGTTCGGGCTGGCGAAAGAAGGCAATGCACCTAAGCAATTTGGCAAGCTATCACGCCGTTCGGTTCC
TGCCACTGGCCTGACATTCTCTTGTATCTGTCTGTTAGGCGGGGTGGTGCTGATTTATCTTATCCCGAACGTGATGACGG
TCTTTACCTTGGTTACCACTGTTTCGGCCATTCTGTTTATGTTCGTCTGGACCATCATCCTTTGCTCTTATTTGGTGTAT
CGCAAAAGACGCCCAGCACTGCATAAAAAATCCATCTACAAAATGCCAGCCGGTATTTTTATGTCATGGGTTTGTATGGC
GTTTTTCGCCTTTGTTTTGGTACTGCTGACATTGGAAAGTGATACCCGTCAGGCGTTAATTGTTACACCGCTATGGTTTG
TCATTTTGACTGCCAGCTATATCTTCCTGAAAAAACGCAGAGCCCGTTTATATAACAGTAAATAA

Upstream 100 bases:

>100_bases
AAATTATCTTTAATGCATAAAAAACAGACAGACAGGTCAAACAGATAAAACCAAAGAGCCAATCTAGAGCTCAATAACTT
CACAAATACAGGAAGAGGGA

Downstream 100 bases:

>100_bases
CCACAGTGTGATAAAACGGTGCCAGAGGTGTTCTGGTACCGTTTTATTTCCCCCTCTAATCACTTATTCCATAACGCCGA
CAACCCGCTACTGAATAAGG

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MGKMVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGEL
LLSNLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVVAITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMF
GEMEFWFAMIKIVAIVALIFAGLTMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAE
TKDPEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFS
TSRMLFGLAKEGNAPKQFGKLSRRSVPATGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVY
RKRRPALHKKSIYKMPAGIFMSWVCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK

Sequences:

>Translated_474_residues
MGKMVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGEL
LLSNLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVVAITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMF
GEMEFWFAMIKIVAIVALIFAGLTMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAE
TKDPEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFS
TSRMLFGLAKEGNAPKQFGKLSRRSVPATGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVY
RKRRPALHKKSIYKMPAGIFMSWVCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK
>Mature_473_residues
GKMVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELL
LSNLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVVAITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMFG
EMEFWFAMIKIVAIVALIFAGLTMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAET
KDPEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFST
SRMLFGLAKEGNAPKQFGKLSRRSVPATGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYR
KRRPALHKKSIYKMPAGIFMSWVCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI114326544, Length=352, Percent_Identity=21.5909090909091, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI114326550, Length=352, Percent_Identity=21.5909090909091, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790653, Length=465, Percent_Identity=81.9354838709677, Blast_Score=779, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=39.2543859649123, Blast_Score=344, Evalue=6e-96,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=40.958605664488, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1786789, Length=463, Percent_Identity=37.1490280777538, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI48994972, Length=463, Percent_Identity=40.1727861771058, Blast_Score=338, Evalue=6e-94,
Organism=Escherichia coli, GI87081915, Length=472, Percent_Identity=37.5, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1788480, Length=476, Percent_Identity=34.2436974789916, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789017, Length=439, Percent_Identity=31.8906605922551, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI87081708, Length=392, Percent_Identity=32.9081632653061, Blast_Score=227, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=359, Percent_Identity=25.3481894150418, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324061, Length=467, Percent_Identity=32.5481798715203, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=481, Percent_Identity=30.5613305613306, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=403, Percent_Identity=30.7692307692308, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=449, Percent_Identity=29.6213808463252, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=497, Percent_Identity=27.7665995975855, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=456, Percent_Identity=28.0701754385965, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=390, Percent_Identity=29.7435897435897, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=415, Percent_Identity=27.4698795180723, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324059, Length=456, Percent_Identity=27.6315789473684, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319824, Length=416, Percent_Identity=26.2019230769231, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=427, Percent_Identity=26.6978922716628, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320251, Length=429, Percent_Identity=26.3403263403263, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=26.2295081967213, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=25.5639097744361, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=437, Percent_Identity=24.9427917620137, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=436, Percent_Identity=27.9816513761468, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=436, Percent_Identity=27.0642201834862, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=495, Percent_Identity=23.6363636363636, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24666159, Length=412, Percent_Identity=22.3300970873786, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221512776, Length=412, Percent_Identity=22.3300970873786, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550968, Length=500, Percent_Identity=25.2, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19921172, Length=500, Percent_Identity=25.2, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52313; Mature: 52182

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKMVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSII
CCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHH
FVYMIIGFMLFFVMRAMGELLLSNLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DVVAITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMFGEMEFWFAMIKIVAIVALIF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLTMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAE
HHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TKDPEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAAS
CCCCCEECCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHH
VINFVVLTSAASSANSGVFSTSRMLFGLAKEGNAPKQFGKLSRRSVPATGLTFSCICLLG
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
GVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKRRPALHKKSIYKMPAGIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHH
MSWVCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK
HHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GKMVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSII
CCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHH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HHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]