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The map label for this gene is hisI

Identifier: 218928683

GI number: 218928683

Start: 1757885

End: 1758499

Strand: Reverse

Name: hisI

Synonym: YPO1542

Alternate gene names: 218928683

Gene position: 1758499-1757885 (Counterclockwise)

Preceding gene: 218928684

Following gene: 218928679

Centisome position: 37.79

GC content: 49.76

Gene sequence:

>615_bases
GTGTTAACAGAACAACAAATCAACCAATTGGATTGGGAAAAAGTCGATCACCTGATGCCAGCCATCGTTCAGCATGCCGT
ATCCGGCGAAGTTCTGATGATGGGGTATATGAATCAGGAAGCACTGGCGGTCACTGAGAAAACCGGCAAAGTGACCTTCT
TCTCTCGTACCAAACAGCGTTTGTGGACCAAAGGCGAAAGCTCTGGTCATTTCCTTAACGTAGTGAATATTTACCCTGAT
TGTGACAACGATACGTTGCTGATTCTGGTGAAGCCTATCGGCCCAACCTGCCACTTGGGCAATAGCAGTTGCTTCGCGCC
TGCGGCCAGTGACTGGAGTTTCCTGTATCAACTGGAGCAATTGTTGGCATCGCGTAAGTCTGCTGATCCAGCCAGTTCTT
ACACGGCAAAACTGTATGCCAGCGGCACCAAACGTATCGCGCAAAAGGTGGGTGAAGAAGGGGTTGAAACCGCACTGGCC
GCCACAGTGAATGACCGTGAAGAGCTAACGAATGAAGCCTCTGATTTGATGTATCACCTGCTGGTGTTATTGCAGGATCA
AGATTTGGATTTCAGTACCGTCATTGGCCGCCTGCGGGAACGCCACGAGAAATAA

Upstream 100 bases:

>100_bases
ATGTTGATGGCGCGCTGGCGGCATCGGTATTCCATAAACAAATCATTAATATCGGCGAATTGAAAAAGTATTTGTCTGAA
CAGGGCGTGGAGATAAGAGT

Downstream 100 bases:

>100_bases
TTCTCTGGCTGATTCACTGGCAAAAAAACGCCTCCAACTTATCACTGGAGGCGTTTTTATTGGGCAGCGTTAAAACGGAT
GAGTCGCTGGTATCTTAAAT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQRLWTKGESSGHFLNVVNIYPD
CDNDTLLILVKPIGPTCHLGNSSCFAPAASDWSFLYQLEQLLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLMYHLLVLLQDQDLDFSTVIGRLRERHEK

Sequences:

>Translated_204_residues
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQRLWTKGESSGHFLNVVNIYPD
CDNDTLLILVKPIGPTCHLGNSSCFAPAASDWSFLYQLEQLLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLMYHLLVLLQDQDLDFSTVIGRLRERHEK
>Mature_204_residues
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQRLWTKGESSGHFLNVVNIYPD
CDNDTLLILVKPIGPTCHLGNSSCFAPAASDWSFLYQLEQLLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLMYHLLVLLQDQDLDFSTVIGRLRERHEK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=80.2955665024631, Blast_Score=337, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319819, Length=206, Percent_Identity=30.0970873786408, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_YERPE (Q8ZFY1)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0188
- RefSeq:   NP_669931.1
- RefSeq:   NP_992795.1
- RefSeq:   YP_002346558.1
- ProteinModelPortal:   Q8ZFY1
- GeneID:   1147575
- GeneID:   1174381
- GeneID:   2765682
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1542
- KEGG:   ypk:y2628
- KEGG:   ypm:YP_1431
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- ProtClustDB:   PRK02759
- BioCyc:   YPES187410:Y2628-MONOMER
- BioCyc:   YPES214092:YPO1542-MONOMER
- BRENDA:   3.5.4.19
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 22807; Mature: 22807

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQR
CCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEHHHHHHH
LWTKGESSGHFLNVVNIYPDCDNDTLLILVKPIGPTCHLGNSSCFAPAASDWSFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHHH
LLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALAATVNDREELTNEASDLMYHL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLQDQDLDFSTVIGRLRERHEK
HHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQR
CCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEHHHHHHH
LWTKGESSGHFLNVVNIYPDCDNDTLLILVKPIGPTCHLGNSSCFAPAASDWSFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHHH
LLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALAATVNDREELTNEASDLMYHL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLQDQDLDFSTVIGRLRERHEK
HHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430