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The map label for this gene is ampH [H]

Identifier: 218928381

GI number: 218928381

Start: 1384727

End: 1385893

Strand: Reverse

Name: ampH [H]

Synonym: YPO1224

Alternate gene names: 218928381

Gene position: 1385893-1384727 (Counterclockwise)

Preceding gene: 218928382

Following gene: 218928378

Centisome position: 29.78

GC content: 49.7

Gene sequence:

>1167_bases
ATGGATAAAAGATTGTTGAAACGTCTCTCTGCCCCGCTGCTGGCTGCTGCTTTGTGGACTATTCCGTTGCACAGCCATGC
CGATACTCAGCCGTTGACCTCGCAAGATACTAAACTGTTGACCTCGCAAATTGTTGACCAATACGCCGAACATATCTTCT
ATAACAGTGGAGCTGTAGGAATGGCTCTGGTGGTTATCGATAACAATCAGGTCGTCAACCGTAGCTTTGGTGAAACGCAA
CCCGGCAACAATATTCGCCCACGGCCAGACTCACTGATCCGCATTGCATCAATAACCAAGCTAATGACCAGCGAAATCAT
GGTAAAACTGGCTGATGATGGCATCGTTAAGTTAACTGACCCGTTAAAAAAATATGCACCGAAAGGGGTCAACGTTCCCT
CTTACAGTGCTAAGCAACCTATTAGGCTGTTGCATCTGGCCAGCCATACCAGCGGCCTCCCCCGTGAGCAACCCGGCGGC
CCGCAAAAAAGACCGGTGTTTACCTGGCCGACCAAAGATAATCGCTGGCAATGGTTGAAACTGGCCAAAGTGACCGTTCC
ACCAGGCGTGAAAGCCGCTTACTCTAATTTAGCTTACGACTTACTGGCTGACGCACTGTCACGAGCTGCGGGGAAACCGT
ATGCCCACTTATTACGTGATAAAATCACCGCACCACTGGGGATGAAAAATACCACCCTGACCCCGACGGCGGAGCAATGT
AAACGCCTGATGATAGGTGTTGGCAGCAGTCGTTGTGGGAATACAGTTGCAGCAGCAGGTAGTGGCGGCATTTACTCGAC
CCCCGAAGATATGCAGCACTGGATGCAACAATTCTTAGCTTCTGATAACAGCGCCCCCAAGCGTTCCGCCAAACGTGAGC
AAGCGCTTTACTTCCAGCGCGGTGACTTGGTGTCATTGAAAGGTATGGATGTCGCCGGTCAAGCTGATGCTCTGGGCTTA
GGCTGGGTTTATATGGCACCTAAAGCTGACTTACCGGGCATTATGCAAAAAACCGGCGGTGGCGGTGGATTTATTACTTA
TATGGCGATGGTCCCAGAAAAAAACATTGGCGTTTTTGTGGTGGTCACACGAAGCCAACTGACTAAATTCAGCAATATGA
GTGATGGTGTGAATCAATTGGTTGCTGAGTTGGTGAAAAATCATTGA

Upstream 100 bases:

>100_bases
CCTTGTAATGTAAATTATTCATCTGATTGAAAATTTCAGCATGTATTATGTAAATATCCGATTACTATAAGCGCACGATC
ACTTATTTTGCCTTTTAAAC

Downstream 100 bases:

>100_bases
TGTAGCACGGCGGCAGGGTAAATACTGCCGCCAATCTCTATCGGCCTGAACTGACCGTTGTTGACTGCATACCCCGTAAT
GAGAGCAATAGCCCGCACCG

Product: beta-lactam binding protein AmpH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDKRLLKRLSAPLLAAALWTIPLHSHADTQPLTSQDTKLLTSQIVDQYAEHIFYNSGAVGMALVVIDNNQVVNRSFGETQ
PGNNIRPRPDSLIRIASITKLMTSEIMVKLADDGIVKLTDPLKKYAPKGVNVPSYSAKQPIRLLHLASHTSGLPREQPGG
PQKRPVFTWPTKDNRWQWLKLAKVTVPPGVKAAYSNLAYDLLADALSRAAGKPYAHLLRDKITAPLGMKNTTLTPTAEQC
KRLMIGVGSSRCGNTVAAAGSGGIYSTPEDMQHWMQQFLASDNSAPKRSAKREQALYFQRGDLVSLKGMDVAGQADALGL
GWVYMAPKADLPGIMQKTGGGGGFITYMAMVPEKNIGVFVVVTRSQLTKFSNMSDGVNQLVAELVKNH

Sequences:

>Translated_388_residues
MDKRLLKRLSAPLLAAALWTIPLHSHADTQPLTSQDTKLLTSQIVDQYAEHIFYNSGAVGMALVVIDNNQVVNRSFGETQ
PGNNIRPRPDSLIRIASITKLMTSEIMVKLADDGIVKLTDPLKKYAPKGVNVPSYSAKQPIRLLHLASHTSGLPREQPGG
PQKRPVFTWPTKDNRWQWLKLAKVTVPPGVKAAYSNLAYDLLADALSRAAGKPYAHLLRDKITAPLGMKNTTLTPTAEQC
KRLMIGVGSSRCGNTVAAAGSGGIYSTPEDMQHWMQQFLASDNSAPKRSAKREQALYFQRGDLVSLKGMDVAGQADALGL
GWVYMAPKADLPGIMQKTGGGGGFITYMAMVPEKNIGVFVVVTRSQLTKFSNMSDGVNQLVAELVKNH
>Mature_388_residues
MDKRLLKRLSAPLLAAALWTIPLHSHADTQPLTSQDTKLLTSQIVDQYAEHIFYNSGAVGMALVVIDNNQVVNRSFGETQ
PGNNIRPRPDSLIRIASITKLMTSEIMVKLADDGIVKLTDPLKKYAPKGVNVPSYSAKQPIRLLHLASHTSGLPREQPGG
PQKRPVFTWPTKDNRWQWLKLAKVTVPPGVKAAYSNLAYDLLADALSRAAGKPYAHLLRDKITAPLGMKNTTLTPTAEQC
KRLMIGVGSSRCGNTVAAAGSGGIYSTPEDMQHWMQQFLASDNSAPKRSAKREQALYFQRGDLVSLKGMDVAGQADALGL
GWVYMAPKADLPGIMQKTGGGGGFITYMAMVPEKNIGVFVVVTRSQLTKFSNMSDGVNQLVAELVKNH

Specific function: Binds penicillin and contributes to the normal morphology [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI239747261, Length=340, Percent_Identity=27.6470588235294, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI239752721, Length=340, Percent_Identity=27.6470588235294, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI239741085, Length=340, Percent_Identity=27.6470588235294, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1786574, Length=388, Percent_Identity=61.8556701030928, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1790593, Length=334, Percent_Identity=23.6526946107784, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 42200; Mature: 42200

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRLLKRLSAPLLAAALWTIPLHSHADTQPLTSQDTKLLTSQIVDQYAEHIFYNSGAVG
CCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
MALVVIDNNQVVNRSFGETQPGNNIRPRPDSLIRIASITKLMTSEIMVKLADDGIVKLTD
EEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
PLKKYAPKGVNVPSYSAKQPIRLLHLASHTSGLPREQPGGPQKRPVFTWPTKDNRWQWLK
HHHHHCCCCCCCCCCCCCCCHHHEEEHHHCCCCCCCCCCCCCCCCEEECCCCCCCEEEEE
LAKVTVPPGVKAAYSNLAYDLLADALSRAAGKPYAHLLRDKITAPLGMKNTTLTPTAEQC
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
KRLMIGVGSSRCGNTVAAAGSGGIYSTPEDMQHWMQQFLASDNSAPKRSAKREQALYFQR
HHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEC
GDLVSLKGMDVAGQADALGLGWVYMAPKADLPGIMQKTGGGGGFITYMAMVPEKNIGVFV
CCEEEECCCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCEEE
VVTRSQLTKFSNMSDGVNQLVAELVKNH
EEEHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKRLLKRLSAPLLAAALWTIPLHSHADTQPLTSQDTKLLTSQIVDQYAEHIFYNSGAVG
CCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
MALVVIDNNQVVNRSFGETQPGNNIRPRPDSLIRIASITKLMTSEIMVKLADDGIVKLTD
EEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
PLKKYAPKGVNVPSYSAKQPIRLLHLASHTSGLPREQPGGPQKRPVFTWPTKDNRWQWLK
HHHHHCCCCCCCCCCCCCCCHHHEEEHHHCCCCCCCCCCCCCCCCEEECCCCCCCEEEEE
LAKVTVPPGVKAAYSNLAYDLLADALSRAAGKPYAHLLRDKITAPLGMKNTTLTPTAEQC
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
KRLMIGVGSSRCGNTVAAAGSGGIYSTPEDMQHWMQQFLASDNSAPKRSAKREQALYFQR
HHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEC
GDLVSLKGMDVAGQADALGLGWVYMAPKADLPGIMQKTGGGGGFITYMAMVPEKNIGVFV
CCEEEECCCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCEEE
VVTRSQLTKFSNMSDGVNQLVAELVKNH
EEEHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]