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The map label for this gene is eco

Identifier: 218928370

GI number: 218928370

Start: 1364859

End: 1365368

Strand: Reverse

Name: eco

Synonym: YPO1211

Alternate gene names: 218928370

Gene position: 1365368-1364859 (Counterclockwise)

Preceding gene: 218928371

Following gene: 218928368

Centisome position: 29.34

GC content: 47.06

Gene sequence:

>510_bases
ATGAAAAAATGCTCAATCATATTAGCCAGTGTATTACTAGCGACATCAATCAATGCCATTGCTGATACGCCTACGCCTCT
CAATCAGCAGCAGCCATTAGAAAAAATCGCACCTTATCCACAAGCTGAAAAAGGGATGAGCCGACAGGTCATTTTTCTTG
AGCCTCAAAAAGATGAAAGCCGCTTTAAAGTTGAGCTGCTGATCGGTAAAACTCTCAACGTTGACTGTAACCGCCACATG
CTCGGCGGCAATCTGGAAACCAGAACATTATCTGGTTGGGGATTCGATTATCTGGTGATGGATAAAATCTCACAACCCGC
CTCAACCATGATGGCTTGCCCTGAAGACAGTAAACCGCAAGTGAAATTTGTTACCGCCAATTTGGGCGACGCGGCAATGC
AGCGTTACAACAGCCGCCTACCCATTGTGGTCTATGTACCGCAAGGGGTGGAAGTCAAATACCGGATCTGGGAAGCGGGC
GAAGATATCAGAAGTGCGCAGGTCAAATAG

Upstream 100 bases:

>100_bases
ATACAGGCCGGAGAGATCCTACCCTGTTGTTGTCAACCCAAGGGCAACATTGAAATCGAGTTTTAGAGACGTATTGCTGA
TAAAACTTAGAGAAAAAAAG

Downstream 100 bases:

>100_bases
CACTCATTAACCAGGCGCTATTCCGCGCCTGGGCTAAATATTAACATTCTCTTTTAATTACAAAATCTCAATAATATCCA
ACCAACCATGCTGCCCGCAC

Product: ecotin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MKKCSIILASVLLATSINAIADTPTPLNQQQPLEKIAPYPQAEKGMSRQVIFLEPQKDESRFKVELLIGKTLNVDCNRHM
LGGNLETRTLSGWGFDYLVMDKISQPASTMMACPEDSKPQVKFVTANLGDAAMQRYNSRLPIVVYVPQGVEVKYRIWEAG
EDIRSAQVK

Sequences:

>Translated_169_residues
MKKCSIILASVLLATSINAIADTPTPLNQQQPLEKIAPYPQAEKGMSRQVIFLEPQKDESRFKVELLIGKTLNVDCNRHM
LGGNLETRTLSGWGFDYLVMDKISQPASTMMACPEDSKPQVKFVTANLGDAAMQRYNSRLPIVVYVPQGVEVKYRIWEAG
EDIRSAQVK
>Mature_169_residues
MKKCSIILASVLLATSINAIADTPTPLNQQQPLEKIAPYPQAEKGMSRQVIFLEPQKDESRFKVELLIGKTLNVDCNRHM
LGGNLETRTLSGWGFDYLVMDKISQPASTMMACPEDSKPQVKFVTANLGDAAMQRYNSRLPIVVYVPQGVEVKYRIWEAG
EDIRSAQVK

Specific function: General inhibitor of pancreatic serine proteases:inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases

COG id: COG4574

COG function: function code R; Serine protease inhibitor ecotin

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protease inhibitor I11 (ecotin) family

Homologues:

Organism=Escherichia coli, GI1788538, Length=164, Percent_Identity=64.6341463414634, Blast_Score=206, Evalue=6e-55,

Paralogues:

None

Copy number: 260 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): ECOT_YERP3 (A7FKF8)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401736.1
- ProteinModelPortal:   A7FKF8
- SMR:   A7FKF8
- STRING:   A7FKF8
- MEROPS:   I11.001
- GeneID:   5388523
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2772
- eggNOG:   COG4574
- HOGENOM:   HBG710412
- OMA:   RYDSRLP
- ProtClustDB:   PRK03719
- BioCyc:   YPSE349747:YPSIP31758_2772-MONOMER
- HAMAP:   MF_00706
- InterPro:   IPR005658
- InterPro:   IPR023189
- InterPro:   IPR023084
- Gene3D:   G3DSA:2.60.40.550
- PIRSF:   PIRSF006865

Pfam domain/function: PF03974 Ecotin; SSF49772 Prot_inh_ecotin

EC number: NA

Molecular weight: Translated: 18871; Mature: 18871

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKCSIILASVLLATSINAIADTPTPLNQQQPLEKIAPYPQAEKGMSRQVIFLEPQKDES
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCC
RFKVELLIGKTLNVDCNRHMLGGNLETRTLSGWGFDYLVMDKISQPASTMMACPEDSKPQ
EEEEEEEECCEEECCCCCEEECCCCCEEEECCCCCCEEEEHHCCCCCHHEEECCCCCCCC
VKFVTANLGDAAMQRYNSRLPIVVYVPQGVEVKYRIWEAGEDIRSAQVK
EEEEEECCCHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCHHCCCC
>Mature Secondary Structure
MKKCSIILASVLLATSINAIADTPTPLNQQQPLEKIAPYPQAEKGMSRQVIFLEPQKDES
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCC
RFKVELLIGKTLNVDCNRHMLGGNLETRTLSGWGFDYLVMDKISQPASTMMACPEDSKPQ
EEEEEEEECCEEECCCCCEEECCCCCEEEECCCCCCEEEEHHCCCCCHHEEECCCCCCCC
VKFVTANLGDAAMQRYNSRLPIVVYVPQGVEVKYRIWEAGEDIRSAQVK
EEEEEECCCHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA