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The map label for this gene is tyrP [H]

Identifier: 218928368

GI number: 218928368

Start: 1361781

End: 1362989

Strand: Reverse

Name: tyrP [H]

Synonym: YPO1209

Alternate gene names: 218928368

Gene position: 1362989-1361781 (Counterclockwise)

Preceding gene: 218928370

Following gene: 218928366

Centisome position: 29.29

GC content: 49.55

Gene sequence:

>1209_bases
GTGAAGAATCGCACTCTGGGCAGTATATTTATCGTTGCAGGTACCACCATTGGTGCGGGCATGTTGGCCATGCCACTGGC
GGCGGCCGGCGTAGGGTTTGGCGTCACACTGGCCTTGCTTGTTTCTCTTTGGTTATTAATGTGTTACACCGCATTATTGC
TGGTGGAAGTTTATCAATATGAAGCGGCTGATACCGGGCTTGGTACATTAGCCAAACGTTACCTCGGTGGCCATGGTCAA
TGGCTGACGGGTTTCAGTATGATGTTTCTGATGTATGCGCTTACTGCGGCTTATATCAGTGGTGCTGGCGAGTTATTGGC
AACCAGTATCAGCCAATGGACTCAGCAATCATTCCCGACCTATCTCGGCGTTTTACTGTTTACCCTAGTCGCCGGAGGAG
TGGTTTGCATCGGTACCCATTCGGTCGATTTGTTCAATCGTATCCTGTTCAGTGCCAAAATCATTTTCCTGATCGTAATG
CTGGCACTGATGATGCCGCATATCGAAAAAACCAACCTACTGACATTGCCGCTAGAGCAAGGGCTAGCACTCTCTGCGAT
CCCGGTAATTTTTACGTCATTCGGTTTCCACGGCAGCGTACCCAGCATTGTTAATTATATGGGCGGTAATATCCGTAAAC
TGCGCTGGGTATTTATCATCGGCAGTGCGATACCGCTTATCGCTTATATCTTCTGGCAATTAGCGACACTGGGGGCGATT
TCCTCTCATACTTTTGTCGGTATTCTGGCCCAGCAAGCGGGTTTGAACGGTTTACTCCAGGCTGTGCGCGACGTCGTGGC
CTCTCCCCATGTCGAACTGGCGGTGCATTTGTTTGCTGATCTGGCACTGGCAACCTCATTCCTGGGGGTAGCATTAGGGC
TATTTGACTATTTGGCTGATTTATTTAAACGCCGAAATTCCATACGTGGCCGTTTACAAACGGGGTTAATTACCTTTACG
CCGCCATTACTGTTTGCGCTGTTTTATCCGCGTGGCTTTATTATGGCGTTGGGTTTTGCCGCTGTGGCATTGTCAGTATT
GGCATTAATTCTGCCTGCAATGTTAGCGTGGAAAGCCCGTAAACTTCATCAGGGCAAATATCAGGTTTGGGGTGGGAGAC
CCGCGCTGGCAATCGTGTTTGCCTGTGGTGTTACCGTGATTGGTATTCAGATTGGTATTGTCACTGGCGCATTACCTGCG
GTAGGGTGA

Upstream 100 bases:

>100_bases
TAAATGAGCCCCATTTGAGGTTCACCCGGCGGGCGAGTATAAATGCTGGCCGTGATGCCATTGAGTTGGGGTATAAATAG
CCATAGTAGTAGAGGAAAGC

Downstream 100 bases:

>100_bases
TACGTAAGCAATAATAAGGGCGCATATCCTGATAGGAATGCGCCCTTTTCCGTCAGCCCAACGTCATTTCCGTTAACCCA
AAGCCCTTATCCGTTAACCC

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFGVTLALLVSLWLLMCYTALLLVEVYQYEAADTGLGTLAKRYLGGHGQ
WLTGFSMMFLMYALTAAYISGAGELLATSISQWTQQSFPTYLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKIIFLIVM
LALMMPHIEKTNLLTLPLEQGLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLIAYIFWQLATLGAI
SSHTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFKRRNSIRGRLQTGLITFT
PPLLFALFYPRGFIMALGFAAVALSVLALILPAMLAWKARKLHQGKYQVWGGRPALAIVFACGVTVIGIQIGIVTGALPA
VG

Sequences:

>Translated_402_residues
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFGVTLALLVSLWLLMCYTALLLVEVYQYEAADTGLGTLAKRYLGGHGQ
WLTGFSMMFLMYALTAAYISGAGELLATSISQWTQQSFPTYLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKIIFLIVM
LALMMPHIEKTNLLTLPLEQGLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLIAYIFWQLATLGAI
SSHTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFKRRNSIRGRLQTGLITFT
PPLLFALFYPRGFIMALGFAAVALSVLALILPAMLAWKARKLHQGKYQVWGGRPALAIVFACGVTVIGIQIGIVTGALPA
VG
>Mature_402_residues
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFGVTLALLVSLWLLMCYTALLLVEVYQYEAADTGLGTLAKRYLGGHGQ
WLTGFSMMFLMYALTAAYISGAGELLATSISQWTQQSFPTYLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKIIFLIVM
LALMMPHIEKTNLLTLPLEQGLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLIAYIFWQLATLGAI
SSHTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFKRRNSIRGRLQTGLITFT
PPLLFALFYPRGFIMALGFAAVALSVLALILPAMLAWKARKLHQGKYQVWGGRPALAIVFACGVTVIGIQIGIVTGALPA
VG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=79.1563275434243, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1789552, Length=369, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1790145, Length=409, Percent_Identity=33.0073349633252, Blast_Score=205, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42928; Mature: 42928

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFGVTLALLVSLWLLMCYTALLLVEVYQY
CCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAADTGLGTLAKRYLGGHGQWLTGFSMMFLMYALTAAYISGAGELLATSISQWTQQSFPT
HCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKIIFLIVMLALMMPHIEKTNLLTLPLEQ
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHC
GLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLIAYIFWQLATLGAI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEEEEHHHHHHHHHHHHHHHHHHHHH
SSHTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDYLAD
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFKRRNSIRGRLQTGLITFTPPLLFALFYPRGFIMALGFAAVALSVLALILPAMLAWKAR
HHHHHHHHHHHHHHCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLHQGKYQVWGGRPALAIVFACGVTVIGIQIGIVTGALPAVG
HHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFGVTLALLVSLWLLMCYTALLLVEVYQY
CCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAADTGLGTLAKRYLGGHGQWLTGFSMMFLMYALTAAYISGAGELLATSISQWTQQSFPT
HCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKIIFLIVMLALMMPHIEKTNLLTLPLEQ
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHC
GLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLIAYIFWQLATLGAI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEEEEHHHHHHHHHHHHHHHHHHHHH
SSHTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDYLAD
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFKRRNSIRGRLQTGLITFTPPLLFALFYPRGFIMALGFAAVALSVLALILPAMLAWKAR
HHHHHHHHHHHHHHCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLHQGKYQVWGGRPALAIVFACGVTVIGIQIGIVTGALPAVG
HHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]