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The map label for this gene is galE

Identifier: 218928304

GI number: 218928304

Start: 1285296

End: 1286312

Strand: Reverse

Name: galE

Synonym: YPO1139

Alternate gene names: 218928304

Gene position: 1286312-1285296 (Counterclockwise)

Preceding gene: 218928305

Following gene: 218928303

Centisome position: 27.64

GC content: 52.51

Gene sequence:

>1017_bases
ATGTACGTTCTGGTAACAGGTGGTAGCGGTTACATTGGTAGCCATACCTGTGTGCAATTGATTGAGGCTGGCTACAAACC
CGTCATCCTCGACAACCTCTGCAACAGTAAATCCAGCGTATTAGCCCGGATACACAGTTTGACCGGCTATACGCCTGAAC
TTTATGCGGGTGATATCCGTGATCGCACACTGCTCGATAGCATTTTTGCGGCTCATCCTATTCATGCCGTCATTCATTTT
GCCGGTCTGAAAGCGGTTGGCGAATCCGTCAACCGGCCACTCGAGTATTACAACAACAACGTGTTTGGCACCTTGGTGTT
ATTAGAAGCGATGCGCGCCGCACAGGTTAAGAACCTGATTTTCAGCTCCTCAGCCACTGTTTATGGCGATCAGCCACAGA
TTCCCTATGTAGAAAGCTTCCCGACCGGTTCACCGTCCAGCCCCTATGGCCGCAGTAAATTGATGGTTGAGCAAATTCTG
CAAGATGTTCAACTGGCTGATCCACAGTGGAATATGACGATTTTGCGCTATTTCAACCCCGTCGGTGCGCACCCATCGGG
TTTGATGGGCGAAGATCCGCAAGGTATCCCGAATAATTTAATGCCGTTTATTGCTCAAGTCGCCGTTGGCCGCCGTGAAT
CACTGGCCATCTTTGGCAATGGCTACCCAACCCCTGATGGTACTGGCGTCCGTGACTATATCCATGTGGTGGATCTGGCT
GACGGCCATGTGGCCGCAATGAAAACCTTACACGGCAAGCCCGGCGTGCATATCTTCAATCTGGGGGCCGGTGTCGGCCA
CAGTGTGTTGCAAGTGGTGGCCGCATTCAGTAAAGCCTGTGGTAAACCACTGGCCTACCATTTTGCCCCGCGCCGCGAAG
GGGATCTGCCTGCCTACTGGGCTGATGCAACTAAAGCGGCGGAACAACTAGGCTGGCGAGTCAGCCGCTCACTTGATGAG
ATGGCGGCAGATACTTGGCACTGGCAATCAAAAAATCCTCAAGGCTACCCCGATTAA

Upstream 100 bases:

>100_bases
AAATTGAGTGTAAACGATTCCATTATTGAGCGTAGATCACCTTTTTACCCATAATGGCGTGCTATCTTTATTGCATTGAA
CTCATTAGAGGAGTCTTATT

Downstream 100 bases:

>100_bases
GGCAATTTTATGACGCATTTTAACCCTGTGGATCATCCACATCGTCGCTATAACCCGTTGAAAGACCAGTGGGTATTGGT
CTCGCCTCATCGGGCTAAAC

Product: UDP-galactose-4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MYVLVTGGSGYIGSHTCVQLIEAGYKPVILDNLCNSKSSVLARIHSLTGYTPELYAGDIRDRTLLDSIFAAHPIHAVIHF
AGLKAVGESVNRPLEYYNNNVFGTLVLLEAMRAAQVKNLIFSSSATVYGDQPQIPYVESFPTGSPSSPYGRSKLMVEQIL
QDVQLADPQWNMTILRYFNPVGAHPSGLMGEDPQGIPNNLMPFIAQVAVGRRESLAIFGNGYPTPDGTGVRDYIHVVDLA
DGHVAAMKTLHGKPGVHIFNLGAGVGHSVLQVVAAFSKACGKPLAYHFAPRREGDLPAYWADATKAAEQLGWRVSRSLDE
MAADTWHWQSKNPQGYPD

Sequences:

>Translated_338_residues
MYVLVTGGSGYIGSHTCVQLIEAGYKPVILDNLCNSKSSVLARIHSLTGYTPELYAGDIRDRTLLDSIFAAHPIHAVIHF
AGLKAVGESVNRPLEYYNNNVFGTLVLLEAMRAAQVKNLIFSSSATVYGDQPQIPYVESFPTGSPSSPYGRSKLMVEQIL
QDVQLADPQWNMTILRYFNPVGAHPSGLMGEDPQGIPNNLMPFIAQVAVGRRESLAIFGNGYPTPDGTGVRDYIHVVDLA
DGHVAAMKTLHGKPGVHIFNLGAGVGHSVLQVVAAFSKACGKPLAYHFAPRREGDLPAYWADATKAAEQLGWRVSRSLDE
MAADTWHWQSKNPQGYPD
>Mature_338_residues
MYVLVTGGSGYIGSHTCVQLIEAGYKPVILDNLCNSKSSVLARIHSLTGYTPELYAGDIRDRTLLDSIFAAHPIHAVIHF
AGLKAVGESVNRPLEYYNNNVFGTLVLLEAMRAAQVKNLIFSSSATVYGDQPQIPYVESFPTGSPSSPYGRSKLMVEQIL
QDVQLADPQWNMTILRYFNPVGAHPSGLMGEDPQGIPNNLMPFIAQVAVGRRESLAIFGNGYPTPDGTGVRDYIHVVDLA
DGHVAAMKTLHGKPGVHIFNLGAGVGHSVLQVVAAFSKACGKPLAYHFAPRREGDLPAYWADATKAAEQLGWRVSRSLDE
MAADTWHWQSKNPQGYPD

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=55.2941176470588, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=55.2941176470588, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=55.2941176470588, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI7657641, Length=275, Percent_Identity=31.6363636363636, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI42516563, Length=334, Percent_Identity=23.9520958083832, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=76.0355029585799, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1788353, Length=368, Percent_Identity=27.445652173913, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI48994969, Length=355, Percent_Identity=27.887323943662, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=48.4057971014493, Blast_Score=344, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=48.1268011527378, Blast_Score=343, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI17568069, Length=333, Percent_Identity=24.9249249249249, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=51.0204081632653, Blast_Score=341, Evalue=1e-94,
Organism=Drosophila melanogaster, GI19923002, Length=344, Percent_Identity=53.7790697674419, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI21356223, Length=315, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALE_YERPE (Q9F7D4)

Other databases:

- EMBL:   AF282311
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0140
- RefSeq:   NP_670343.1
- RefSeq:   NP_992394.1
- RefSeq:   YP_002346179.1
- ProteinModelPortal:   Q9F7D4
- SMR:   Q9F7D4
- GeneID:   1147990
- GeneID:   1173989
- GeneID:   2763289
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1139
- KEGG:   ypk:y3043
- KEGG:   ypm:YP_1020
- HOGENOM:   HBG755066
- OMA:   AECWAST
- ProtClustDB:   PRK10675
- BioCyc:   YPES187410:Y3043-MONOMER
- BioCyc:   YPES214092:YPO1139-MONOMER
- BRENDA:   5.1.3.2
- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF39
- TIGRFAMs:   TIGR01179

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.2

Molecular weight: Translated: 36732; Mature: 36732

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: ACT_SITE 149-149 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVLVTGGSGYIGSHTCVQLIEAGYKPVILDNLCNSKSSVLARIHSLTGYTPELYAGDIR
CEEEEECCCCCCCHHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHHHCCCCCCHHCCCCC
DRTLLDSIFAAHPIHAVIHFAGLKAVGESVNRPLEYYNNNVFGTLVLLEAMRAAQVKNLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
FSSSATVYGDQPQIPYVESFPTGSPSSPYGRSKLMVEQILQDVQLADPQWNMTILRYFNP
HCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEHEEECCC
VGAHPSGLMGEDPQGIPNNLMPFIAQVAVGRRESLAIFGNGYPTPDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHEEEEECC
DGHVAAMKTLHGKPGVHIFNLGAGVGHSVLQVVAAFSKACGKPLAYHFAPRREGDLPAYW
CCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCH
ADATKAAEQLGWRVSRSLDEMAADTWHWQSKNPQGYPD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MYVLVTGGSGYIGSHTCVQLIEAGYKPVILDNLCNSKSSVLARIHSLTGYTPELYAGDIR
CEEEEECCCCCCCHHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHHHCCCCCCHHCCCCC
DRTLLDSIFAAHPIHAVIHFAGLKAVGESVNRPLEYYNNNVFGTLVLLEAMRAAQVKNLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
FSSSATVYGDQPQIPYVESFPTGSPSSPYGRSKLMVEQILQDVQLADPQWNMTILRYFNP
HCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEHEEECCC
VGAHPSGLMGEDPQGIPNNLMPFIAQVAVGRRESLAIFGNGYPTPDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHEEEEECC
DGHVAAMKTLHGKPGVHIFNLGAGVGHSVLQVVAAFSKACGKPLAYHFAPRREGDLPAYW
CCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCH
ADATKAAEQLGWRVSRSLDEMAADTWHWQSKNPQGYPD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430