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The map label for this gene is galK

Identifier: 218928302

GI number: 218928302

Start: 1283086

End: 1284237

Strand: Reverse

Name: galK

Synonym: YPO1137

Alternate gene names: 218928302

Gene position: 1284237-1283086 (Counterclockwise)

Preceding gene: 218928303

Following gene: 218928301

Centisome position: 27.6

GC content: 51.22

Gene sequence:

>1152_bases
ATGAGTTTAAAACAACATACCCAGACTATTTTCCGCCAACAGTTTGACCGCGAGTCTGACATCACCATTAAAGCGCCGGG
CCGCGTCAATCTGATTGGCGAACATACCGACTATAACGATGGCTTTGTTCTGCCCTGCGCCATTAATTATGAAACGGTGA
TCAGTTGTGGCAAACGCGACGATCGCCAGATTCGTGTTATTGCCGCCGACTATGAAAACCAGCAGGATATATTCTCTCTT
GATGCACCGATTGTCCCGCATCCTGAATATCGCTGGGCTGACTACGTGCGTGGTGTGGTGAAACATCTACAAATGCGCAA
CGCTGATTTTGGTGGGGCCGATCTGGTTATCTGTGGCAATGTCCCGCAGGGTGCTGGCCTCAGTTCCTCTGCATCGTTGG
AAGTGGCCGTGGGCCAAGCCCTGCAATCACTCTATCAACTCCCTCTTAGCGGTGTAGAACTGGCGCTGAATGGGCAAGAG
GCAGAAAACCAATTTGTCGGCTGTAACTGCGGCATTATGGATCAGTTAATCTCAGCATTGGGTAAAAAAGACCATGCGTT
GCTGATTGATTGTCGGACCTTGGAAACCCGTGCCGTGCCAATGCCGGAAAACATGGCCGTCGTTATTATCAACTCAAACA
TTCAACGTGGCCTGGTTGACAGCGAATACAATACTCGCCGCCAACAGTGTGAAGCTGCCGCCCGTTTCTTTGGCGTCAAA
GCATTGCGTGATGTCGAACCGAGCCTCTTCTTCTCAATACAAGACGAGCTAGATCCGGTCGTCGCTAAACGCGCCCGCCA
TGTGATCAGCGAGAATGCACGCACGCTGGCAGCCGCAGATGCCTTGGCCGCCGGGAACTTGAAATTGATGGGGCAATTGA
TGCAAGAGTCTCATATTTCTATGCGTGATGACTTTGAGATCACGGTTCCACCAATAGATAGACTCGTCGAGATTGTGAAA
TCAGTGATTGGTGATCAAGGTGGGGTGCGCATGACGGGTGGCGGTTTTGGCGGTTGTATTATCGCGTTAATGCCGCTTGA
ATTAGTCGAGCAGGTTCGCACCACCGTTGCGCAAGAATACCCGGCACACAGCGGCGGCAAGAAAGAGACTTTTTATGTCT
GTCAGGCTTCACAAGGAGCGGGTTTATGCTGA

Upstream 100 bases:

>100_bases
AACTGCTGGCCGAAACCCAGCGAGACCTTACAGCAGAACAGGCGGCAGCACTCCTGCGGGCAGTAAGTGATGTTCACTAT
AAAGAGGCCGGAGCCAAATC

Downstream 100 bases:

>100_bases
AAAACGGCGCGGCATCACCAAACAGTGTTGACCCGTTAGCACCGGATGGTCACCCTTTTGAATTCACCAAATTGCAGAAT
AAAAGCGGTATGACCGTCAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRDDRQIRVIAADYENQQDIFSL
DAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGNVPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHISMRDDFEITVPPIDRLVEIVK
SVIGDQGGVRMTGGGFGGCIIALMPLELVEQVRTTVAQEYPAHSGGKKETFYVCQASQGAGLC

Sequences:

>Translated_383_residues
MSLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRDDRQIRVIAADYENQQDIFSL
DAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGNVPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHISMRDDFEITVPPIDRLVEIVK
SVIGDQGGVRMTGGGFGGCIIALMPLELVEQVRTTVAQEYPAHSGGKKETFYVCQASQGAGLC
>Mature_382_residues
SLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRDDRQIRVIAADYENQQDIFSLD
APIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGNVPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQEA
ENQFVGCNCGIMDQLISALGKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVKA
LRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHISMRDDFEITVPPIDRLVEIVKS
VIGDQGGVRMTGGGFGGCIIALMPLELVEQVRTTVAQEYPAHSGGKKETFYVCQASQGAGLC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=382, Percent_Identity=43.717277486911, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI48527957, Length=440, Percent_Identity=27.0454545454545, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4503897, Length=440, Percent_Identity=27.0454545454545, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1786972, Length=383, Percent_Identity=72.5848563968668, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71989053, Length=404, Percent_Identity=28.960396039604, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319494, Length=252, Percent_Identity=30.1587301587302, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320212, Length=328, Percent_Identity=26.219512195122, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24661292, Length=412, Percent_Identity=27.6699029126214, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21355577, Length=412, Percent_Identity=27.6699029126214, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24661285, Length=412, Percent_Identity=27.6699029126214, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_YERP3 (A7FKP2)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401820.1
- ProteinModelPortal:   A7FKP2
- STRING:   A7FKP2
- GeneID:   5385326
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2857
- eggNOG:   COG0153
- HOGENOM:   HBG725121
- OMA:   CREMIAR
- ProtClustDB:   PRK05101
- BioCyc:   YPSE349747:YPSIP31758_2857-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 41866; Mature: 41735

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRD
CCHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECHHHHHHCCCCC
DRQIRVIAADYENQQDIFSLDAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGN
CCEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
VPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
CCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHIS
HHHHCCCHHEEEEHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
MRDDFEITVPPIDRLVEIVKSVIGDQGGVRMTGGGFGGCIIALMPLELVEQVRTTVAQEY
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
PAHSGGKKETFYVCQASQGAGLC
CCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
SLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRD
CHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECHHHHHHCCCCC
DRQIRVIAADYENQQDIFSLDAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGN
CCEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
VPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
CCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHIS
HHHHCCCHHEEEEHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
MRDDFEITVPPIDRLVEIVKSVIGDQGGVRMTGGGFGGCIIALMPLELVEQVRTTVAQEY
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
PAHSGGKKETFYVCQASQGAGLC
CCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA