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The map label for this gene is rnhA [H]

Identifier: 218928250

GI number: 218928250

Start: 1228698

End: 1229162

Strand: Reverse

Name: rnhA [H]

Synonym: YPO1081

Alternate gene names: 218928250

Gene position: 1229162-1228698 (Counterclockwise)

Preceding gene: 218928252

Following gene: 218928248

Centisome position: 26.41

GC content: 49.68

Gene sequence:

>465_bases
ATGACTAAACAGGTAGAAATTTTCACCGATGGCTCCTGCCTCGGTAATCCAGGCCCTGGGGGCTATGGCGCAATTTTACG
TTACAAACAACACGAAAAAACGTTTAGTGCCGGCTATTATTTGACCACCAACAACCGTATGGAACTGATGGCAGCCATTG
TGGCGCTTGAGGCATTGACCTCGCCTTGCGAAGTGACCCTAAGTACTGATAGCCAATATGTGCGTCAGGGTATCACTCAA
TGGATCCATAACTGGAAAAAACGCGGCTGGAAAACAGCCGATCGTAAGCCAGTGCGCAATGTGGACTTATGGCAGCGTCT
GGATTTAGCTATTCAGAGCCATACCATACAGTGGGAGTGGGTTAAGGGCCATGCGGGTCATCCAGAAAACGAACGTTGCG
ATGAACTGGCCCGGCAGGGAGCTAATTCACCGACACTCGATGATACGGGCTATAACCCTGATTAA

Upstream 100 bases:

>100_bases
GAACAATCTGTCTGGTCGGTGTAATGATCATATTGCAGTGCTCACAGCGCTCGTTTATGTCAGACTTGACGTTTAAACAG
ATAGGAAGAGTCTACCAGAG

Downstream 100 bases:

>100_bases
TCCTACTAGCTTGGCGTGTTAGCGGCTCTTACTCATTCGAATGATTGACTTGACTCAGGGTTGATCCCGGTAACTTTTTG
TTGCACCAACGGCCCGGCTA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MTKQVEIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYYLTTNNRMELMAAIVALEALTSPCEVTLSTDSQYVRQGITQ
WIHNWKKRGWKTADRKPVRNVDLWQRLDLAIQSHTIQWEWVKGHAGHPENERCDELARQGANSPTLDDTGYNPD

Sequences:

>Translated_154_residues
MTKQVEIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYYLTTNNRMELMAAIVALEALTSPCEVTLSTDSQYVRQGITQ
WIHNWKKRGWKTADRKPVRNVDLWQRLDLAIQSHTIQWEWVKGHAGHPENERCDELARQGANSPTLDDTGYNPD
>Mature_153_residues
TKQVEIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYYLTTNNRMELMAAIVALEALTSPCEVTLSTDSQYVRQGITQW
IHNWKKRGWKTADRKPVRNVDLWQRLDLAIQSHTIQWEWVKGHAGHPENERCDELARQGANSPTLDDTGYNPD

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=146, Percent_Identity=36.986301369863, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1786408, Length=151, Percent_Identity=84.7682119205298, Blast_Score=273, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI115532542, Length=140, Percent_Identity=36.4285714285714, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17505482, Length=132, Percent_Identity=35.6060606060606, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137476, Length=144, Percent_Identity=38.8888888888889, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI45552509, Length=144, Percent_Identity=38.8888888888889, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 17464; Mature: 17333

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQVEIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYYLTTNNRMELMAAIVALEALT
CCCEEEEEECCCCCCCCCCCCHHHHEEEHHHCCEECCCEEEEECCHHHHHHHHHHHHHHC
SPCEVTLSTDSQYVRQGITQWIHNWKKRGWKTADRKPVRNVDLWQRLDLAIQSHTIQWEW
CCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEE
VKGHAGHPENERCDELARQGANSPTLDDTGYNPD
EECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKQVEIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYYLTTNNRMELMAAIVALEALT
CCEEEEEECCCCCCCCCCCCHHHHEEEHHHCCEECCCEEEEECCHHHHHHHHHHHHHHC
SPCEVTLSTDSQYVRQGITQWIHNWKKRGWKTADRKPVRNVDLWQRLDLAIQSHTIQWEW
CCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEE
VKGHAGHPENERCDELARQGANSPTLDDTGYNPD
EECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA