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The map label for this gene is yggV [C]

Identifier: 218928117

GI number: 218928117

Start: 1035573

End: 1036166

Strand: Direct

Name: yggV [C]

Synonym: YPO0945

Alternate gene names: 218928117

Gene position: 1035573-1036166 (Clockwise)

Preceding gene: 218928116

Following gene: 218928118

Centisome position: 22.25

GC content: 53.2

Gene sequence:

>594_bases
ATGCAAAAAATAGTATTAGCCACCGGCAACCCCGGCAAAGTACGTGAACTGGCAAACCTGCTGGCCGACTTTGGTTTGGA
TGTCGTCGCACAAACCGAACTGGGCGTTGAGTCTGCAGAAGAGACGGGCTTAACCTTTATTGAAAACGCCATTTTAAAAG
CCCGCCATGCAGCGCAAACCACCGGTTTACCGGCCATCGCCGATGATTCAGGCTTAGCAGTAGACGCGTTAGGCGGCGCT
CCGGGGATTTATTCCGCACGCTATGCCGGTACTGATGCCAGTGACCAAGAGAATCTGGAAAAGCTGTTGGTCGCATTGCA
AAATGTCCCCGATGAAAAACGCGGTGCTCAGTTCCATTGCGTATTGGTCTATATGCGTCATGCTGAAGATCCAACACCGC
TGGTGTTCCACGGCCAATGGCCAGGGGTAATTGCTCACCAACCTGCTGGGGCTGCTGGGTTTGGCTATGACCCTATTTTC
TATGTACCCGCGCTGGGTAAAACCGCAGCGGAACTGACTCGTGAAGAAAAGCACGCGGTATCCCATCGTGGTCAGGCCCT
GAAATTGATGCTGGATGCGCTGCGCGATGCTTAA

Upstream 100 bases:

>100_bases
AGTTGATATTCCTCCGCAAGAATTGGGTTATTGGTTGTCAGCCCAACAGACTGCGCTCAATACCGATAGCCGTCAGCCTA
TAAAAATTCAGGATTCATCG

Downstream 100 bases:

>100_bases
ATTACCCCCGCTCAGTCTCTACATCCATATCCCTTGGTGCGTCCAGAAATGCCCTTATTGTGATTTCAACTCACATGCGT
TGAAAGGCGATGTCCCTCAT

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGA
PGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIF
YVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA

Sequences:

>Translated_197_residues
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGA
PGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIF
YVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA
>Mature_197_residues
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGA
PGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIF
YVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=189, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1789324, Length=196, Percent_Identity=79.5918367346939, Blast_Score=332, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI17556833, Length=197, Percent_Identity=28.4263959390863, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920712, Length=190, Percent_Identity=33.6842105263158, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_YERPE (Q8ZHF4)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AI0115
- RefSeq:   YP_002345992.1
- ProteinModelPortal:   Q8ZHF4
- SMR:   Q8ZHF4
- IntAct:   Q8ZHF4
- GeneID:   1173781
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0945
- KEGG:   ypk:y3331
- KEGG:   ypm:YP_3497
- HOGENOM:   HBG697237
- OMA:   TGVTFAE
- ProtClustDB:   PRK00120
- BioCyc:   YPES187410:Y3331-MONOMER
- BioCyc:   YPES214092:YPO0945-MONOMER
- BRENDA:   3.6.1.15
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 20906; Mature: 20906

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQT
CCEEEEEECCCHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHCCHHHHHHHHHHHHHHHHH
TGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHC
CCCCCEECCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCHHCCEEEE
VLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIFYVPALGKTAAELTREEKHAV
EEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
SHRGQALKLMLDALRDA
HHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQT
CCEEEEEECCCHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHCCHHHHHHHHHHHHHHHHH
TGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHC
CCCCCEECCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCHHCCEEEE
VLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIFYVPALGKTAAELTREEKHAV
EEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
SHRGQALKLMLDALRDA
HHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430