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The map label for this gene is proC [H]

Identifier: 218928114

GI number: 218928114

Start: 1033523

End: 1034344

Strand: Direct

Name: proC [H]

Synonym: YPO0942

Alternate gene names: 218928114

Gene position: 1033523-1034344 (Clockwise)

Preceding gene: 218928113

Following gene: 218928115

Centisome position: 22.21

GC content: 50.97

Gene sequence:

>822_bases
ATGCAGCATCGCAATATTACATTCATTGGTGCTGGCAATATGGCCCGCGCTATTATCGCTGGTTTGGTTGCCGGGGGATA
TCCGGCCAAAATGATCAGCGTTTGCGCCCCTTCTGCCAAAAACCGTGATGCACTAGCCACTGAATTTGGTGTTATCAGCA
GTGATGATAATATCCGCGAGTCACAAAAAGCGGAGGTTGTGGTGTTAGCGGTAAAGCCCCAGTTAATGGCCGATGTATGC
CAGCAATTGCAAAAACAGGTCGATTTTAGCGATAAGTTGGTGCTGTCGATTGCGGCAGGTGTCCAGGTTGCACGTTTCTA
CGCGCTTTTGGGGAATAAACTGAATCTGGTTCGTATTATGCCGAATACCCCCTCTCTGGTGGGAAAAGGAATGAGTGGCC
TCTACGCCCCCGAGCAGGTTTCAGCCGCAGATCGTGATTTCACCACTGAACTAATGAGTGCAATTGGCAAAGTATGCTGG
GTGGACAATGAGGATGGCATTAATAGCATTATTGCCGCTGCGGGGAGTTCACCTGCCTATTTCTTCTTATTTATGGAAGC
GATGCAGCAAGAGACTGAACGCTTAGGGTTTGACAGTGAAACCGCCCGTCAGTTAGTGCAGCAAGCCGCTTCCGGGGCTT
GTGCTCTGGTCGAGGCTAACCCACACGTGCCACTTTCGGCCTTGCGAGAGCAGGTCACGTCCAAAGGGGGAACCACTGCC
GAGGCAATCCGCGTGTTCAATGAACAGCACTTACCCGAAATGGTTGCCAATGCCATGCGAGCCGCTATTGCTCGCGCAAA
AGAGATGGAAAAACTGTTCTAA

Upstream 100 bases:

>100_bases
ACATAACTCTCTGTTGAACGTAATTATTTGTTGAACATCAGTTCCTGTTGAACATAAGTCCTCGTTGAACATAAAGACTG
TGCACGCTTAGGAGAATTCG

Downstream 100 bases:

>100_bases
TTAGCGGCGAAAGTTACAAAAACCGACACCGCCCTTGGCACTTTCTCGTTAAAATAGGGGCCGTTAAAGTATGTGAATAG
ATTTTTTATTTGTACCTAAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRESQKAEVVVLAVKPQLMADVC
QQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIMPNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCW
VDNEDGINSIIAAAGSSPAYFFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
EAIRVFNEQHLPEMVANAMRAAIARAKEMEKLF

Sequences:

>Translated_273_residues
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRESQKAEVVVLAVKPQLMADVC
QQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIMPNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCW
VDNEDGINSIIAAAGSSPAYFFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
EAIRVFNEQHLPEMVANAMRAAIARAKEMEKLF
>Mature_273_residues
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRESQKAEVVVLAVKPQLMADVC
QQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIMPNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCW
VDNEDGINSIIAAAGSSPAYFFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
EAIRVFNEQHLPEMVANAMRAAIARAKEMEKLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=274, Percent_Identity=27.007299270073, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI24797095, Length=278, Percent_Identity=28.0575539568345, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24797097, Length=278, Percent_Identity=28.0575539568345, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=26.3736263736264, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=33.9483394833948, Blast_Score=140, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=29.7397769516729, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=29.1814946619217, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=287, Percent_Identity=25.4355400696864, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=30.2238805970149, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=29.3478260869565, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=28.0701754385965, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29281; Mature: 29281

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00521 P5CR ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRE
CCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCC
SQKAEVVVLAVKPQLMADVCQQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIM
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCWVDNEDGINSIIAAAGSSPAY
CCCHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCHH
FFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCHH
EAIRVFNEQHLPEMVANAMRAAIARAKEMEKLF
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRE
CCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCC
SQKAEVVVLAVKPQLMADVCQQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIM
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCWVDNEDGINSIIAAAGSSPAY
CCCHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCHH
FFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCHH
EAIRVFNEQHLPEMVANAMRAAIARAKEMEKLF
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]