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The map label for this gene is lysR [H]

Identifier: 218927977

GI number: 218927977

Start: 876844

End: 877785

Strand: Direct

Name: lysR [H]

Synonym: YPO0797

Alternate gene names: 218927977

Gene position: 876844-877785 (Clockwise)

Preceding gene: 218927975

Following gene: 218927980

Centisome position: 18.84

GC content: 51.27

Gene sequence:

>942_bases
ATGCCTGCAATTTCCTTACGACAAATCGAGATTTTTCATGGCGTCATGACCACGGGCAACCTGACTGAAGCGGCGTTGTT
ACTGCAAACATCACAACCGACTGTCAGCCGCGAATTGGCCCGCTTTGAGCAATTGGTGCAACTCACGCTTTTTGAACGGG
TACGTGGCCGCCTTTATCCTACCGTGCAAGGGCTACGGCTATTCGAAGAGGTTCAGCGTTCATATTATGGTTTGGATCGT
ATCAAACAGGCGGCTGAAGGTATCCGCCAATTTCAACATGCCCAACTCTCCATTGCCTGCCTGCCCGTCTTTTCTCAATC
GTTGCTACCCGCGGTATGTAAACCCTTTATTGACCGCTATCCAGAGGTCAGCCTAAATGTCATTCCGCAGGAGTCACCTT
TATTGGAGGAGTGGTTTTCAGCCCAGCGTCATGACTTAGGACTCACAGAAAATATCCAAACACCGGCGGGCACCCAGCGC
CATACCCTGATGACGGTCAATGAAGTTTGCGTATTACCTGCCGATCATCCGTTGCGGGAGAAATCGGTGCTGACACCACA
GGATTTTAACGGGGAAAATTTTGTCAGCCTGTCAGTCACCGACAGTTACCGTCAGCTATTGGATAACCTGTTTGCGGAGG
AAAAAGTCACCCGCCGATTAGTCATGGAGACCCACAGTGCGGCATCGGTTTGCGCCATGGTGCGTGAAGGGGTGGGGGTA
TCGATAGTCAACCCCCTTACCGCACTGGATTACCTGAGTAAAGGCCGTGGTTCGGGGGTTTGTGTACGGCCATTCAGTGT
CGACATTCCTTTTACGGTTAGCTTAATTCAGCCATTACATCGCCCATCATCCACCTTGGTCGATACGTTTGTCGGGCACT
TAAAACAGCAGACAACGCTTTTCCAACAGCGTCTGGCAACAGTCATTGCCCCTGCGTGCTAA

Upstream 100 bases:

>100_bases
ATTAACGTTGTGGATTTGTTAGGAAAATATCTATTTACCCTTAGTCTATTCATTTATGATATGGGTTAAATTGATCAGTT
CGCGTTTCAGGAGTGCGAGA

Downstream 100 bases:

>100_bases
GCCATTTTATTCCCAATAGTACGCGCGCGGGAAAAGGTAAACAGACACAGCAACAACCCCATGACCGCCAGTGCCGCGGC
GGCCAGCGGCACCGCCGTCA

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYPTVQGLRLFEEVQRSYYGLDR
IKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSLNVIPQESPLLEEWFSAQRHDLGLTENIQTPAGTQR
HTLMTVNEVCVLPADHPLREKSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTLFQQRLATVIAPAC

Sequences:

>Translated_313_residues
MPAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYPTVQGLRLFEEVQRSYYGLDR
IKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSLNVIPQESPLLEEWFSAQRHDLGLTENIQTPAGTQR
HTLMTVNEVCVLPADHPLREKSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTLFQQRLATVIAPAC
>Mature_312_residues
PAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYPTVQGLRLFEEVQRSYYGLDRI
KQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSLNVIPQESPLLEEWFSAQRHDLGLTENIQTPAGTQRH
TLMTVNEVCVLPADHPLREKSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGVS
IVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTLFQQRLATVIAPAC

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=295, Percent_Identity=71.1864406779661, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI145693105, Length=238, Percent_Identity=23.109243697479, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788887, Length=309, Percent_Identity=24.9190938511327, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=23.4782608695652, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787530, Length=227, Percent_Identity=27.3127753303965, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34984; Mature: 34853

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYP
CCCCCHHHHHHHHHHHCCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLFEEVQRSYYGLDRIKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC
PEVSLNVIPQESPLLEEWFSAQRHDLGLTENIQTPAGTQRHTLMTVNEVCVLPADHPLRE
CCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCEEEECCCCCCCC
KSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTL
EHHHHHHHHHHHHCCCCCCEEEECEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FQQRLATVIAPAC
HHHHHHHHHCCCC
>Mature Secondary Structure 
PAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYP
CCCCHHHHHHHHHHHCCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLFEEVQRSYYGLDRIKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC
PEVSLNVIPQESPLLEEWFSAQRHDLGLTENIQTPAGTQRHTLMTVNEVCVLPADHPLRE
CCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCEEEECCCCCCCC
KSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTL
EHHHHHHHHHHHHCCCCCCEEEECEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FQQRLATVIAPAC
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]