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The map label for this gene is lpxC

Identifier: 218927757

GI number: 218927757

Start: 607125

End: 608045

Strand: Direct

Name: lpxC

Synonym: YPO0561

Alternate gene names: 218927757

Gene position: 607125-608045 (Clockwise)

Preceding gene: 218927756

Following gene: 218927759

Centisome position: 13.05

GC content: 46.04

Gene sequence:

>921_bases
ATGATCAAACAAAGGACTTTAAAACGTATTGTTCAGGCGACGGGTGTCGGTTTGCACACCGGTAAAAAAGTCACGCTGAC
AATGCGACCCGCGCCGGCTAATACCGGGGTCATCTATCGTCGCACTGACTTGAATCCACCGGTTGATTTTCCGGCAGATG
CAAAATCCGTGCGTGATACCATGCTCTGTACTTGCCTGGTCAATGAGCATGACGTGCGTATTTCTACTGTTGAACATCTC
AACGCTGCTTTGGCAGGGTTAGGGATTGATAACATTATTATTGAAGTTAACGCCCCCGAAGTACCAATCATGGATGGCAG
CGCCAGTCCATTCGTGTACTTATTGCTGGATGCCGGTATTGAAGAGTTAAACTCAGCGAAGAAATTCCTGCGTTTGAAAG
AGACAGTACGGGTTGAAGATGGTGATAAATGGGCTGAATTGTCTCCCTTCAATGGATTCCGTTTGGACTTTACCATTGAT
TTTAATCACCCGGCGATTGACTCAAGTACACAGCGTTATTGCTTAGATTTCTCGGCCGATTCTTTCGTCCGCCAAATCAG
CCGTGCGCGTACTTTTGGTTTCATGCGTGATATCGAATATCTGCAGTCCCGCGGTTTGTGCCTGGGCGGTAGTTTCGATT
GTGCCATCGTGGTAGATGATTACCGCGTATTAAATGAAGATGGCCTACGCTTTGAAGATGAGTTTGTTCGTCACAAAATG
TTGGACGCTATTGGCGACCTGTTTATGTGCGGCCATAATATTATTGGCGCATTTACGGCGTACAAATCTGGTCATGCCTT
AAATAACAAGCTGTTGCAGGCTGTTTTAGCGAAGCAAGAAGCTTGGGAATTTGTGACGTTCCAAGATGAAGCTGAAATGC
CTTTGGCATTCAAAGCACCGTCTACAGTATTAGCTTACTAA

Upstream 100 bases:

>100_bases
ATTTCCGAATATTTGGAATCTCCGCTCTTTGTGCTAAACTGTCCCACCGATCTTGTTATAAGCTTGGTCGGTAGGATGGA
TAACATTGCGAGATAAAATG

Downstream 100 bases:

>100_bases
ATATACTTGTACCCAAAGTAATTGGGAGTTGAAGTAATTGAAGTTGTAGCCAGACAGCGAACGAACAGAACCTGCTGAGC
TGATGTAAATCAGTGATTCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHL
NAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGIEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTID
FNHPAIDSSTQRYCLDFSADSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVLAY

Sequences:

>Translated_306_residues
MIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHL
NAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGIEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTID
FNHPAIDSSTQRYCLDFSADSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVLAY
>Mature_306_residues
MIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHL
NAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGIEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTID
FNHPAIDSSTQRYCLDFSADSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVLAY

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=92.7868852459016, Blast_Score=600, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_YERP3 (A7FM60)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402338.1
- ProteinModelPortal:   A7FM60
- SMR:   A7FM60
- STRING:   A7FM60
- GeneID:   5385500
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3381
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- BioCyc:   YPSE349747:YPSIP31758_3381-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 34176; Mature: 34176

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
CCCHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGI
EEEEEEECCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEEEEEHHCH
EELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTIDFNHPAIDSSTQRYCLDFSAD
HHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCHH
SFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECEEEECCCCCCCHHHHHHHHH
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAP
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEECC
STVLAY
CCEECC
>Mature Secondary Structure
MIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
CCCHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGI
EEEEEEECCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEEEEEHHCH
EELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTIDFNHPAIDSSTQRYCLDFSAD
HHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCHH
SFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECEEEECCCCCCCHHHHHHHHH
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAP
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEECC
STVLAY
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA