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The map label for this gene is deoC

Identifier: 218927637

GI number: 218927637

Start: 457275

End: 458072

Strand: Direct

Name: deoC

Synonym: YPO0436

Alternate gene names: 218927637

Gene position: 457275-458072 (Clockwise)

Preceding gene: 218927636

Following gene: 218927638

Centisome position: 9.83

GC content: 50.25

Gene sequence:

>798_bases
ATGACCGATTTAACCGCCTGCGCGCATTTGAACGATTATGCTAAACGCGCACTAAGTTTGATGGATTTAACCACCCTGAA
TGACGACGATACTGATGAAAAAGTGATCGCGCTCTGTCATCAGGCTAAAAGCCCGGCCGGTAATACCGCGGCAATTTGTA
TTTATCCTCGCTTTATCCCGGTTGCCCGTAAGGCGTTACGTGAGCAGGGCACTCCTGAGATCCGTATCGCAACGGTGACC
AACTTCCCTCATGGCAATGATGATGTTGCGATTGCGTTGGCTGAAACCCGTGCTGCCATTGCTTATGGTGCCGATGAAGT
GGATGTGGTTTTCCCTTATCGCGCGTTAATGGCCGGTAACGATAAAATTGGCTTCGAACTCGTGAAAACGTGTAAAGAAG
CCTGCGCTGCGGCGAATGTATTACTGAAAGTCATCATTGAAACTGGCGAACTTAAGCAAGCGCATTTAATTCGTCAGGCC
TCTGAAATTGCAATCAAAGCGGGTGCCGATTTTATTAAAACTTCTACCGGTAAAGTGCCGGTGAATGCCACGTTGGAAAG
TGCAGACATTATGATCCGCACTATCCGTGAGTTAGGCGTAGGCGAAACGGTGGGCTTCAAACCGGCTGGTGGTGTCCGTA
CCGCAGAAGATGCCGCGCAATTTTTGCAATTGGCTGATCAACTGATGGGGGAAGGCTGGGCTGATGCACGCCATTTCCGC
TTTGGCGCTTCCAGTCTACTCGCCAGTTTGCTGACCACATTGGGTCACCAGAGTAACGCCAACAGCAGCGGCTACTAA

Upstream 100 bases:

>100_bases
AGCTTAACCACCGAGAGATACCGCCAAGGATCTTTTCTGCTCATAACTACATGCTCAGTTTTGGCAAACTGCCGGAGCTG
AAACAGTGTTGGAGAGTTTT

Downstream 100 bases:

>100_bases
CGTTATTATCATCATTACACTGAATTGATGCACAGTAGGCTGAAGGCCTGCTGTGTCGCTATTTCCGAAAGCGCCTGTGG
GCGGCTTTCATCCCATATTC

Product: deoxyribose-phosphate aldolase

Products: NA

Alternate protein names: Phosphodeoxyriboaldolase 2; DERA 2; Deoxyriboaldolase 2

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTDLTACAHLNDYAKRALSLMDLTTLNDDDTDEKVIALCHQAKSPAGNTAAICIYPRFIPVARKALREQGTPEIRIATVT
NFPHGNDDVAIALAETRAAIAYGADEVDVVFPYRALMAGNDKIGFELVKTCKEACAAANVLLKVIIETGELKQAHLIRQA
SEIAIKAGADFIKTSTGKVPVNATLESADIMIRTIRELGVGETVGFKPAGGVRTAEDAAQFLQLADQLMGEGWADARHFR
FGASSLLASLLTTLGHQSNANSSGY

Sequences:

>Translated_265_residues
MTDLTACAHLNDYAKRALSLMDLTTLNDDDTDEKVIALCHQAKSPAGNTAAICIYPRFIPVARKALREQGTPEIRIATVT
NFPHGNDDVAIALAETRAAIAYGADEVDVVFPYRALMAGNDKIGFELVKTCKEACAAANVLLKVIIETGELKQAHLIRQA
SEIAIKAGADFIKTSTGKVPVNATLESADIMIRTIRELGVGETVGFKPAGGVRTAEDAAQFLQLADQLMGEGWADARHFR
FGASSLLASLLTTLGHQSNANSSGY
>Mature_264_residues
TDLTACAHLNDYAKRALSLMDLTTLNDDDTDEKVIALCHQAKSPAGNTAAICIYPRFIPVARKALREQGTPEIRIATVTN
FPHGNDDVAIALAETRAAIAYGADEVDVVFPYRALMAGNDKIGFELVKTCKEACAAANVLLKVIIETGELKQAHLIRQAS
EIAIKAGADFIKTSTGKVPVNATLESADIMIRTIRELGVGETVGFKPAGGVRTAEDAAQFLQLADQLMGEGWADARHFRF
GASSLLASLLTTLGHQSNANSSGY

Specific function: Nucleotide and deoxyribonucleotide catabolism. [C]

COG id: COG0274

COG function: function code F; Deoxyribose-phosphate aldolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoC/fbaB aldolase family. DeoC type 2 subfamily

Homologues:

Organism=Homo sapiens, GI116063554, Length=267, Percent_Identity=37.4531835205993, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1790841, Length=265, Percent_Identity=78.4905660377359, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17533015, Length=251, Percent_Identity=37.4501992031873, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI19922098, Length=255, Percent_Identity=37.6470588235294, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEOC2_YERPE (Q8ZIQ4)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0054
- RefSeq:   NP_671037.1
- RefSeq:   NP_995016.1
- RefSeq:   YP_002345512.1
- ProteinModelPortal:   Q8ZIQ4
- SMR:   Q8ZIQ4
- IntAct:   Q8ZIQ4
- GeneID:   1148690
- GeneID:   1173282
- GeneID:   2765384
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0436
- KEGG:   ypk:y3743
- KEGG:   ypm:YP_3745
- HOGENOM:   HBG636421
- OMA:   CKEACGD
- ProtClustDB:   PRK05283
- BioCyc:   YPES187410:Y3743-MONOMER
- BioCyc:   YPES214092:YPO0436-MONOMER
- BRENDA:   4.1.2.4
- GO:   GO:0005737
- HAMAP:   MF_00592
- InterPro:   IPR013785
- InterPro:   IPR011343
- InterPro:   IPR002915
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR10889
- PIRSF:   PIRSF001357
- TIGRFAMs:   TIGR00126

Pfam domain/function: PF01791 DeoC

EC number: =4.1.2.4

Molecular weight: Translated: 28275; Mature: 28143

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: ACT_SITE 173-173 ACT_SITE 207-207

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTACAHLNDYAKRALSLMDLTTLNDDDTDEKVIALCHQAKSPAGNTAAICIYPRFIP
CCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCHHH
VARKALREQGTPEIRIATVTNFPHGNDDVAIALAETRAAIAYGADEVDVVFPYRALMAGN
HHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEECCCCEEEEECHHHHHCCC
DKIGFELVKTCKEACAAANVLLKVIIETGELKQAHLIRQASEIAIKAGADFIKTSTGKVP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
VNATLESADIMIRTIRELGVGETVGFKPAGGVRTAEDAAQFLQLADQLMGEGWADARHFR
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
FGASSLLASLLTTLGHQSNANSSGY
CCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TDLTACAHLNDYAKRALSLMDLTTLNDDDTDEKVIALCHQAKSPAGNTAAICIYPRFIP
CCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCHHH
VARKALREQGTPEIRIATVTNFPHGNDDVAIALAETRAAIAYGADEVDVVFPYRALMAGN
HHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEECCCCEEEEECHHHHHCCC
DKIGFELVKTCKEACAAANVLLKVIIETGELKQAHLIRQASEIAIKAGADFIKTSTGKVP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
VNATLESADIMIRTIRELGVGETVGFKPAGGVRTAEDAAQFLQLADQLMGEGWADARHFR
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
FGASSLLASLLTTLGHQSNANSSGY
CCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430