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The map label for this gene is metC [H]

Identifier: 218927485

GI number: 218927485

Start: 277883

End: 279064

Strand: Direct

Name: metC [H]

Synonym: YPO0278

Alternate gene names: 218927485

Gene position: 277883-279064 (Clockwise)

Preceding gene: 218927484

Following gene: 218927501

Centisome position: 5.97

GC content: 45.43

Gene sequence:

>1182_bases
ATGAATAAAAAAGATATTTCTAGTTTTGGTATTAGTACTCAAATAACACAACTGGGTAGAAATCCACAAGAGCAGACGGG
TTTTGTTAATACACCGATCTATCGGGGGTCCACGGTTATTTTTAATACGGTCGATGACATTGTCAATAATCGTGCTGTTT
TTAACTATGGGACAGCAGGTACTCCCACTATTGCTAATCTAGAGAGTGCGTGGACCGCACTGGCTGGGGCTGCAGGAACC
GTGATTTCCCCTTCTGGCTTGGGGGTGATCGCGTTAGCATTGTTAACAACGCTAAAAGCGGGTGATCACTTGTTGATGCC
AGATAGTGTGTATAAACCGACAAGGTTACTCTGTGCGGGTTTGATCGCTCGGATGGGGGTTGAAACAACATATTATGACC
CATTGATCGGTGCTGAAATTGAAACATTAATGAAGCCGAATACATCGACGTTATTTTTGGAGTCTCCTGGCTCACAAAGC
TTCGAAATTCAGGATATTCCGATGATGACGGCAATCACTAAAAGGCGAGGGATTGCGACAATTATTGATAATACTTGGGC
TTCACCGCTATTTTTTGCCGCCCATAAACATGGCTGTGATTTATCACTTGAGGCGGGTACCAAATATTTGGGCGGGCACT
CTGACCTATTAATGGGGCTGGTGTCGGCGAACGAACAATGGTGGCCTAAATTAAGGGAGACTTATGACTCTATGGCCATG
CTACCGGGGGCTGAGGACTGTTTCTTAGCATTACGTGGCTTAAGGACCCTACATCTACGAATAAAAGAGGCAGAAAAGCG
CGGACTTGAAATGGCGCAATGGCTGAAAGAGCGGCCAGAAGTGTTGCGTGTTTTACATCCGGCCTTTCCTGATTGCCCTG
GACATGAGTTTTGGAAACGTGATTTTACCGGGTCATCAGGTCTATTCTCTATTGTATTAAAGCCCGAATTTACTCAAAAA
GGGTTGGCGGAGATGTTGGACAATATGTCTATCTTTGCTATGGGTTTCTCTTGGGGGGGATATGAGAGCCTGGTGATCCC
TTTTGATTGCTCGGAATACCGCACGGTGACGAAATGGAACCCAGGTGGATTAACCATCCGCTTACAAATCGGTCTTGAGG
ATATGGAGGATCTCAAGGAGGACTTGGCGCAAGGTTTTATTCGGTTAGCATCAAATAGTTAA

Upstream 100 bases:

>100_bases
CAGCTTTTTCGGTATTCTTCTTTGTCTTTCCCCATTCTTTAAATTCTTTGAGTAACGTGGCTAAAAACAGGAATGAATCT
GGTTTAATAAGAGGTAGGTA

Downstream 100 bases:

>100_bases
TTATAGCGGGGCGGATAGTTTTTATCGGCATTTCCGCCCCTTGCTTCAGTTTTGCGGGTGATCTGTTTAGTTGACCATCT
GCTTAGTTGGTGCTTTGGAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNKKDISSFGISTQITQLGRNPQEQTGFVNTPIYRGSTVIFNTVDDIVNNRAVFNYGTAGTPTIANLESAWTALAGAAGT
VISPSGLGVIALALLTTLKAGDHLLMPDSVYKPTRLLCAGLIARMGVETTYYDPLIGAEIETLMKPNTSTLFLESPGSQS
FEIQDIPMMTAITKRRGIATIIDNTWASPLFFAAHKHGCDLSLEAGTKYLGGHSDLLMGLVSANEQWWPKLRETYDSMAM
LPGAEDCFLALRGLRTLHLRIKEAEKRGLEMAQWLKERPEVLRVLHPAFPDCPGHEFWKRDFTGSSGLFSIVLKPEFTQK
GLAEMLDNMSIFAMGFSWGGYESLVIPFDCSEYRTVTKWNPGGLTIRLQIGLEDMEDLKEDLAQGFIRLASNS

Sequences:

>Translated_393_residues
MNKKDISSFGISTQITQLGRNPQEQTGFVNTPIYRGSTVIFNTVDDIVNNRAVFNYGTAGTPTIANLESAWTALAGAAGT
VISPSGLGVIALALLTTLKAGDHLLMPDSVYKPTRLLCAGLIARMGVETTYYDPLIGAEIETLMKPNTSTLFLESPGSQS
FEIQDIPMMTAITKRRGIATIIDNTWASPLFFAAHKHGCDLSLEAGTKYLGGHSDLLMGLVSANEQWWPKLRETYDSMAM
LPGAEDCFLALRGLRTLHLRIKEAEKRGLEMAQWLKERPEVLRVLHPAFPDCPGHEFWKRDFTGSSGLFSIVLKPEFTQK
GLAEMLDNMSIFAMGFSWGGYESLVIPFDCSEYRTVTKWNPGGLTIRLQIGLEDMEDLKEDLAQGFIRLASNS
>Mature_393_residues
MNKKDISSFGISTQITQLGRNPQEQTGFVNTPIYRGSTVIFNTVDDIVNNRAVFNYGTAGTPTIANLESAWTALAGAAGT
VISPSGLGVIALALLTTLKAGDHLLMPDSVYKPTRLLCAGLIARMGVETTYYDPLIGAEIETLMKPNTSTLFLESPGSQS
FEIQDIPMMTAITKRRGIATIIDNTWASPLFFAAHKHGCDLSLEAGTKYLGGHSDLLMGLVSANEQWWPKLRETYDSMAM
LPGAEDCFLALRGLRTLHLRIKEAEKRGLEMAQWLKERPEVLRVLHPAFPDCPGHEFWKRDFTGSSGLFSIVLKPEFTQK
GLAEMLDNMSIFAMGFSWGGYESLVIPFDCSEYRTVTKWNPGGLTIRLQIGLEDMEDLKEDLAQGFIRLASNS

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=353, Percent_Identity=32.5779036827195, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI299473759, Length=353, Percent_Identity=29.7450424929178, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI25453487, Length=352, Percent_Identity=29.5454545454545, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=42.4164524421594, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=29.5918367346939, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=396, Percent_Identity=29.2929292929293, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=294, Percent_Identity=32.6530612244898, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=295, Percent_Identity=32.2033898305085, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=340, Percent_Identity=64.1176470588235, Blast_Score=478, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319307, Length=355, Percent_Identity=25.9154929577465, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6321904, Length=338, Percent_Identity=27.810650887574, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323333, Length=352, Percent_Identity=23.0113636363636, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321254, Length=424, Percent_Identity=24.5283018867925, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922554, Length=386, Percent_Identity=31.6062176165803, Blast_Score=188, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43283; Mature: 43283

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKDISSFGISTQITQLGRNPQEQTGFVNTPIYRGSTVIFNTVDDIVNNRAVFNYGTAG
CCCCCCHHCCCHHHHHHHCCCCCHHCCCCCCCEECCCEEEEECHHHHHCCCEEEECCCCC
TPTIANLESAWTALAGAAGTVISPSGLGVIALALLTTLKAGDHLLMPDSVYKPTRLLCAG
CCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHH
LIARMGVETTYYDPLIGAEIETLMKPNTSTLFLESPGSQSFEIQDIPMMTAITKRRGIAT
HHHHHCCCCEECCCHHCCHHHHHHCCCCCEEEEECCCCCCEEEECCCHHHHHHHHCCCEE
IIDNTWASPLFFAAHKHGCDLSLEAGTKYLGGHSDLLMGLVSANEQWWPKLRETYDSMAM
EECCCCCCCCEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
LPGAEDCFLALRGLRTLHLRIKEAEKRGLEMAQWLKERPEVLRVLHPAFPDCPGHEFWKR
CCCCHHHHHHHHHHHHEEHEEHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
DFTGSSGLFSIVLKPEFTQKGLAEMLDNMSIFAMGFSWGGYESLVIPFDCSEYRTVTKWN
CCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEEC
PGGLTIRLQIGLEDMEDLKEDLAQGFIRLASNS
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKKDISSFGISTQITQLGRNPQEQTGFVNTPIYRGSTVIFNTVDDIVNNRAVFNYGTAG
CCCCCCHHCCCHHHHHHHCCCCCHHCCCCCCCEECCCEEEEECHHHHHCCCEEEECCCCC
TPTIANLESAWTALAGAAGTVISPSGLGVIALALLTTLKAGDHLLMPDSVYKPTRLLCAG
CCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHH
LIARMGVETTYYDPLIGAEIETLMKPNTSTLFLESPGSQSFEIQDIPMMTAITKRRGIAT
HHHHHCCCCEECCCHHCCHHHHHHCCCCCEEEEECCCCCCEEEECCCHHHHHHHHCCCEE
IIDNTWASPLFFAAHKHGCDLSLEAGTKYLGGHSDLLMGLVSANEQWWPKLRETYDSMAM
EECCCCCCCCEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
LPGAEDCFLALRGLRTLHLRIKEAEKRGLEMAQWLKERPEVLRVLHPAFPDCPGHEFWKR
CCCCHHHHHHHHHHHHEEHEEHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
DFTGSSGLFSIVLKPEFTQKGLAEMLDNMSIFAMGFSWGGYESLVIPFDCSEYRTVTKWN
CCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEEC
PGGLTIRLQIGLEDMEDLKEDLAQGFIRLASNS
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]